An Update on Circular RNA in Pediatric Cancers
Abstract
:1. Introduction
Biogenesis, Regulation, and Functions of CircRNAs
2. CircRNAs in Cancer
2.1. Pediatric Brain Tumors
2.1.1. Medulloblastoma
2.1.2. Ependymoma
2.2. Neuroblastoma
2.3. Sarcomas
2.3.1. Rhabdomyosarcoma
2.3.2. Osteosarcoma
2.4. Wilms’ Tumor
2.5. Hepatoblastoma
2.6. Retinoblastoma
Tumor | CircRNA | Related Network | Function | Reference |
---|---|---|---|---|
MB | circ-DTL | Promotion of proliferation | [30] | |
miR-383-5p | Promotion of proliferation | [30] | ||
Promotion of cancer progression | [31] | |||
MB | circSKA3 | miR-326 | Increased proliferation | [32] |
miR-520 h | Promotion of cancer progression | [33] | ||
EP | circRMST, circLRBA circWDR78, circDRC1, and circBBS9 | [34] | ||
NB | circAGO2 (hsa_circ_0135889) | Promotion of tumorigenesis and aggressiveness | [36] | |
NB | circCUX1 | EWS RNA-binding protein | Promotion of glycolysis, growth, and aggressiveness | [37] |
NB | circCUX1 | miR-16-5p/DMTR2 | Promotion of proliferation, migration, invasion, and glucose uptake | [39] |
NB | circCUX1 | miR-388-3p/PHF20 | Promotion of cancer progression | [40] |
NB | circDGKB (has_circ_0133622) | miR-873/GLI1 | Increased proliferation, migration, and invasion | [41] |
NB | has_circ_0002343 | PI3K/Akt/mTOR signaling | Survival | [42] |
NB | has_circ_0001361 | NOTCH2, SERPINH1, LAMC1 | Epithelial-to-mesenchymal transition | [44] |
NB | circTBC1D4, circNAALAD2, circTGFBR3 | miR-21 | Decreased migratory properties | [45] |
NB | circPDE5A (has_circ_0002474) | miR-362-5p/NOL4L | Promotion of proliferation and migration | [46] |
NB | circ_0132817 | miR-432-5p/NOL4L | Promotion of tumor progression | [45] |
NB | circ0125803 | miR-197-5p/E2F1 | Promotion of tumor progression | [48] |
NB | circ_0135889 | miR-127-5p/NEUROD1 | Promotion of proliferation and tumorigenicity | [49] |
NB | circKIF2A (hsa_circ_0129276) | miR-377-3p/PRPS1 | Promotion of cell proliferation, migration, invasion, and glycolysis | [50] |
ERMS | circZNF609 | AKT | Regulation of cell proliferation | [55] |
ARMS | circVAMP3 | AKT | Regulation of cell proliferation | [56] |
OS | has_circ_0001146 | miR-26a-5p/MNAT1 | Promotion of proliferation and invasiveness | [58] |
OS | has_circ_0005909 | miR-338-3p/HMGA1 | Promotion of cancer development | [59] |
WT | circ0093740 | miR-136/145/DNMT3A | Promotion of proliferation and migration ability | [60] |
WT | circCDYL | miR-145-5p/TJP1 | Reduction of cell proliferation, migration, and invasion | [61] |
WT | circSLC7A6 | miR-107/ABL2 | Cancer promotion | [62] |
HB | circ_0015756 | miR-1250-3p | Increased viability, proliferation, and invasion | [63] |
HB | has_circ_0000594 | miR-217/SIRT1 | Promotion of proliferation, viability, and migration | [66] |
HB | circHMGCS1 (has_circ_0072391) | miR-503-5p/IGF-PI3K-Akt signaling | Regulation of glutamine metabolism | [67] |
HB | circ_0043800 | miR-29a/b/c-3p/STAT3/GLI1 | Promotion of tumor growth | [69] |
HB | CDR1as | miR-7-5p/KLF4 | Promotion of proliferation and stemness | [70] |
HB | circSETD3 | miR-423-3p/Bim | Inhibition of proliferation, migration, and EMT and induction of apoptosis | [71] |
RB | has_circ_0001649 | AKT/mTOR | Regulation of proliferation and apoptosis | [72] |
RB | TET1-has_circ_0093996 | miR-183/PDCD4 miR-494/miR-494-3p | Chromatin modification Inhibition of tumor progression | [73] [74] |
RB | circ_0075804 | HNRNPK | Regulation of proliferation | [75] |
RB | circ_ODC1 | miR-422a/SKP2 | Regulation of cell growth | [76] |
miR-646/BCL-2 | Promotion of RB progression | [77] | ||
RB | circ_0000527 | miR-646/LRP6 | Promotion of cell proliferation and migration | [78] |
miR-98-5p/XIAP | Promotion of cell proliferation and migration | [79] | ||
RB | has_circ_0000034 | miR-361-3p/STX17 | Promotion of cell growth | [80,81] |
RB | circMKLN1 | miR-425-5p/PDCD4 | Inhibition of tumor progression | [82] |
RB | circ-FAM158A | miR-138-5p/SLC7A5 | Regulation of cell growth and migration | [83] |
RB | circ_0084811 | miR-18a-5p/miR-18b-5p/E2F5 | Promotion of proliferation and inhibition of apoptosis | [84] |
3. Brief View on circRNAs in Blood Cancers
4. Bioinformatic Tools and Resources for circRNAs
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Algorithm | Aligner | Reference |
---|---|---|
find_circ | Bowtie2 | [6] |
MapSplice | Bowtie | [97] |
CIRCexplorer | TopHat | [16] |
circRNA_finder | STAR | [98] |
CIRI | BWA | [99] |
Salzman 2012 | Bowtie | [100] |
Salzman 2013 | Bowtie2 | [101] |
CircRNAseq | Bowtie | [15] |
Segemehl | Segemehl | [102] |
Guo 2014 | Bowtie | [103] |
KNIFE | Bowtie2 | [104] |
DCC | STAR | [105] |
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Galardi, A.; Colletti, M.; Palma, A.; Di Giannatale, A. An Update on Circular RNA in Pediatric Cancers. Biomedicines 2023, 11, 36. https://doi.org/10.3390/biomedicines11010036
Galardi A, Colletti M, Palma A, Di Giannatale A. An Update on Circular RNA in Pediatric Cancers. Biomedicines. 2023; 11(1):36. https://doi.org/10.3390/biomedicines11010036
Chicago/Turabian StyleGalardi, Angela, Marta Colletti, Alessandro Palma, and Angela Di Giannatale. 2023. "An Update on Circular RNA in Pediatric Cancers" Biomedicines 11, no. 1: 36. https://doi.org/10.3390/biomedicines11010036