Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Design
2.2. Ethical Considerations
2.3. Sample Collection and Processing
2.4. HLA Typing Methodology
2.5. Statistical Analysis
3. Results
3.1. Frequencies of HLA Class I (A and B) in the Study Population
3.2. Frequencies of HLA Class II (DRB1 and DQB1) Loci in the Study Population
3.3. Frequencies of HLA Class I and II Allele Groups Associated with Hepatitis C Infection Outcomes
3.4. Distribution of HLA-A and B Loci Allele Groups According to Gender
3.5. Distribution of HLA-DRB1 and DQB1 Allele Groups According to Gender
3.6. Frequencies of HLA Class I and II Alleles Associated with Outcomes of Hepatitis C Infection According to Gender
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Locus | Sex Ratio | Age Average |
---|---|---|
locus A | ||
684 (353 male, 331 females) | 1.066 | 28.76 |
locus B | ||
684 (353 male, 331 females) | 1.066 | 28.76 |
Locus DRB1 | ||
323 (157 males, 166 females) | 0.94 | 29.39 |
Locus DQB1 | ||
323 (157 males, 166 females) | 0.94 | 29.39 |
HLA Class I | |||
---|---|---|---|
HLA-A Locus | Frequency (%) | HLA-B Locus | Frequency (%) |
A2 | 23,3 | B51 | 9.9 |
A1 | 11.6 | B44 | 9.1 |
A3 | 8.9 | B8 | 6.7 |
A23 | 8 | B49 | 6.4 |
A24 | 8 | B45 | 6 |
A68 | 7.8 | B35 | 5.7 |
A30 | 6.5 | B7 | 5.7 |
A33 | 4 | B50 | 5.2 |
A11 | 3.7 | B14 | 4.4 |
A32 | 3.7 | B18 | 4.2 |
A29 | 3.1 | B58 | 4.2 |
A26 | 2.6 | B27 | 3.7 |
A34 | 2.3 | B38 | 3.1 |
A80 | 1.5 | B53 | 2.6 |
A31 | 1.2 | B40 | 2.5 |
A66 | 1 | B41 | 2.4 |
A28 | 0.8 | B57 | 2.3 |
A74 | 0.8 | B42 | 2.1 |
A10 | 0.4 | B63 | 2.1 |
A36 | 0.2 | B39 | 2 |
A69 | 0.2 | B15 | 1.7 |
A9 | 0.2 | B72 | 1.7 |
A19 | 0.1 | B52 | 1.2 |
A25 | 0.1 | B13 | 1 |
B17 | 0.8 | ||
B37 | 0.7 | ||
B78 | 0.7 | ||
B47 | 0.4 | ||
B21 | 0.3 | ||
B55 | 0.2 | ||
B56 | 0.2 | ||
B62 | 0.2 | ||
B12 | 0.1 | ||
B2 | 0.1 | ||
B64 | 0.1 | ||
B65 | 0.1 | ||
B70 | 0.1 | ||
B71 | 0.1 | ||
B73 | 0.1 |
HLA Class II | |||
---|---|---|---|
HLA-DRB1 Locus | Frequency (%) | HLA-DQB1 Locus | Frequency (%) |
DRB1*03 | 19.2 | DQB1*02 | 33.1 |
DRB1*13 | 15.8 | DQB1*06 | 24.3 |
DRB1*07 | 14.9 | DQB1*03 | 24 |
DRB1*15 | 13.3 | DQB1*05 | 13 |
DRB1*04 | 12.7 | DQB1*04 | 5.4 |
DRB1*11 | 10.1 | DQB1*07 | 0,2 |
DRB1*01 | 7.4 | ||
DRB1*08 | 2.5 | ||
DRB1*09 | 1.5 | ||
DRB1*10 | 0.9 | ||
DRB1*14 | 0.9 | ||
DRB1*12 | 0.6 | ||
DRB1*16 | 0.2 |
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Machraoui, S.; Errafii, K.; Oujamaa, I.; Belghali, M.Y.; Hakmaoui, A.; Lamjadli, S.; Eddehbi, F.E.; Brahim, I.; Haida, Y.; Admou, B. Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study. Diseases 2024, 12, 106. https://doi.org/10.3390/diseases12050106
Machraoui S, Errafii K, Oujamaa I, Belghali MY, Hakmaoui A, Lamjadli S, Eddehbi FE, Brahim I, Haida Y, Admou B. Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study. Diseases. 2024; 12(5):106. https://doi.org/10.3390/diseases12050106
Chicago/Turabian StyleMachraoui, Safa, Khaoula Errafii, Ider Oujamaa, Moulay Yassine Belghali, Abdelmalek Hakmaoui, Saad Lamjadli, Fatima Ezzohra Eddehbi, Ikram Brahim, Yasmine Haida, and Brahim Admou. 2024. "Frequency of the Main Human Leukocyte Antigen A, B, DR, and DQ Loci Known to Be Associated with the Clearance or Persistence of Hepatitis C Virus Infection in a Healthy Population from the Southern Region of Morocco: A Preliminary Study" Diseases 12, no. 5: 106. https://doi.org/10.3390/diseases12050106