In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys
Abstract
:1. Introduction
2. Materials and Methods
2.1. Obtaining Mg-Ca-Zn Biodegradable Alloys and Previous Results
2.2. Reagents for In Vitro Cytotoxicity Tests
2.3. Cytotoxicity Tests, In Vitro (MTT Viability Assay)
2.4. Cell Morphology: Calcein-AM Cell Viability Assay
2.5. Selection of Laboratory Animals
2.6. Pre-Operative Preparations and Surgical Method
3. Results and Discussion
3.1. Cytotoxicity Tests, In Vitro (MTT Viability Assay)
3.2. Cell Morphology: Calcein-AM Cell Viability Assay
3.3. Histologic Analysis and Characterization
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Alloy | Mg [wt.%] | Ca [wt.%] | Zn [wt.%] |
---|---|---|---|
Mg-0.5Ca-0.5Zn | 99.05 | 0.43 | 0.52 |
Mg-0.5Ca-1Zn | 98.40 | 0.56 | 1.04 |
Mg-0.5Ca-1.5Zn | 98.10 | 0.51 | 1.39 |
Mg-0.5Ca-1Zn | 97.64 | 0.62 | 1.74 |
Mg-0.5Ca-3Zn | 96.22 | 0.63 | 3.15 |
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Istrate, B.; Cojocaru, F.-D.; Henea, M.-E.; Balan, V.; Șindilar, E.-V.; Verestiuc, L.; Munteanu, C.; Solcan, C. In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys. J. Funct. Biomater. 2024, 15, 166. https://doi.org/10.3390/jfb15060166
Istrate B, Cojocaru F-D, Henea M-E, Balan V, Șindilar E-V, Verestiuc L, Munteanu C, Solcan C. In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys. Journal of Functional Biomaterials. 2024; 15(6):166. https://doi.org/10.3390/jfb15060166
Chicago/Turabian StyleIstrate, Bogdan, Florina-Daniela Cojocaru, Mădălina-Elena Henea, Vera Balan, Eusebiu-Viorel Șindilar, Liliana Verestiuc, Corneliu Munteanu, and Carmen Solcan. 2024. "In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys" Journal of Functional Biomaterials 15, no. 6: 166. https://doi.org/10.3390/jfb15060166