New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study
Abstract
:1. Introduction
2. Aim
3. Materials and Methods
4. Results
5. Discussion
Author Contributions
Funding
Conflicts of Interest
References
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Place of the Test | BoP | PD śr | PD | Mediana PD > 5 mm | Mediana CAL1-2 | Mediana CAL3-4 | Mediana CAL ≥ 5 |
---|---|---|---|---|---|---|---|
Upper Jaw | 63.3 ± 22.3 | 4.23 ± 0.92 | 4.86 ± 1.15 | 10 | 7.5 | 13 | 26 |
30.3 ± 12.1 p < 0.000 | 3.78 ± 0.97 p = 0.049 | 4.31 ± 1.12 p = 0.047 | 5.5 p = 0.59 | 11 p = 0.17 | 7.5 p = 0.44 | 14.5 p = 0.012 | |
Pockets SRP+A | 87.5 ± 20.9 | 5.0 ± 1.04 | CAL śr 3.96 ± 1.36 | ||||
38.3 ± 12.5 p < 0.000 | 4.18 ± 0.92 p = 0.008 | 3.1 ± 2.02 p = 0.053 | |||||
Pockets SRP | 85.8 ± 14.2 | 4.83 ± 1.18 | 3.41 ± 1.63 | ||||
38.3 ± 23.9 p < 0.000 | 4.0 ± 0.99 p = 0.005 | 2.6 ± 1.34 p = 0.037 |
Type of Bacteria | SRP+A Treatment | SRP Treatment | P for Rows |
---|---|---|---|
TBC before after | 455,603,800 ± 774,832,582 225,700,000 ± 160,305,299 T26, p = 0.88 | 138,810,000 ± 184,812,292 400,090,000 ± 710,668,522 T16, p = 0.24 | U = 50 ns U = 50 ns |
P.g. before after | 55,050 ± 105,157 94,000 ± 239,040 T8, p = 0.6 | 54,328 ± 146,867 182,514 ± 365,513 T5, p = 0.25 | U = 43 ns U = 47 ns |
T.d. before after | 4802 ± 5793 36,188 ± 79,754 T3, p = 0.036 | 6456 ± 11,483 35,460 ± 50,421 T9, p = 0.11 | U = 42 ns U = 48.5 ns |
T.f. before after | 11,372 ± 23,587 7996 ± 10,964 T11, p = 0.33 | 40,227 ± 106,011 16,657 ± 29,545 T21, p = 0.86 | U = 49.5 ns U = 47 ns |
A.a before after | Liczba wykryć-3 Liczba wykryć-2 | Liczba wykryć-2 Liczba wykryć-1 | |
F.n. before after | 6800 ± 14,499 466 ± 615 T10, p = 0.26 | 8257 ± 18,822 716 ± 1320 T6, p = 0.051 | U = 35 ns U = 43 ns |
P.i. before after | 43,404 ± 106,163 199,610 ± 497,956 T8, p = 0.6 | 61,153 ± 144,493 23,765 ± 69,086 T5, p = 0.25 | U = 46 ns U = 40 ns |
P.m. before after | 2877 ± 2644 631 ± 767 T3, p = 0.036 | 5914 ± 11,514 589 ± 616 T6, p = 0.051 | U = 49.5 ns U = 48.5 ns |
E.n. before after | Liczba wykryć-1 Liczba wykryć-1 | Liczba wykryć-1 Liczba wykryć-2 | |
C.g. before after | 14,636 ± 37,211 5439 ± 4962 T25, p = 0.8 | 5878 ± 6165 2050 ± 1796 T8, p = 0.086 | U = 41.5 ns U = 22.5 |
Type of Bacteria | Stage II and III vs. IV | p | Grade B vs. C | p |
---|---|---|---|---|
TBC before after | 404,295,571 ± 660,136,448 vs. 473,333,333 ± 493,301,180 386,071,429 ± 595,735,933 vs. 142,150,000 ± 114,175,369 | 0.23 0.16 | 410,078,571 ± 656,851,542 vs. 33,839,667 ± 42,535,311 369,428,571 ± 602,988,291 vs. 180,983,333 ± 102,863,996 | 0.048 0.74 |
P.g. before after | 64,141 ± 145,840 vs. 32,633 ± 50,957 73,439 ± 230,011 vs. 289,500 ± 417,614 | 0.59 0.59 | 68,641 ± 144,276 vs. 22,133 ± 52,856 79,653 ± 229,047 vs. 275,000 ± 427,446 | 0.3 0.71 |
T.d. before after | 5731 ± 9219 vs. 5392 ± 8920 40,956 ± 74,652 vs. 23,850 ± 35,928 | 0.9 0.48 | 7438 ± 10,099 vs. 1408 ± 2223 41,263 ± 74,510 vs. 23,133 ± 36,272 | 0.3 0.54 |
T.f. before after | 32,595 ± 90,773 vs. 9943 ± 14,466 11,238 ± 21,684 vs. 14,867 ± 25,083 | 0.62 0.77 | 34,431 ± 90,504 vs. 5660 ± 8455 11,224 ± 21,730 vs.15,133 ± 24,856 | 0.71 0.97 |
A.a before after | Liczba wykryć-3 vs. 2 Liczba wykryć-2 vs. 1 | Liczba wykryć-3 vs. 2 Liczba wykryć-2 vs. 1 | ||
F.n. before after | 9221 ± 19,245 vs. 3578 ± 5346 565 ± 856 vs. 652 ± 1405 | 0.59 0.65 | 9264 ± 19,221 vs. 3478 ± 5442 457 ± 873 vs. 903 ± 1318 | 0.97 0.26 |
P.i. before after | 40,398 ± 92,291 vs. 80,000 ± 186,333 148,125 ± 424,800 vs. 26,667 ± 65,320 | 0.53 0.2 | 66,669 ± 14,447 vs. 18,700 ± 44,736 158,075 ± 423,223 vs. 3450 ± 7209 | 0.34 0.33 |
P.m. before after | 2948 ± 2751 vs. 7773 ± 14,874 695 ± 676 vs. 412 ± 702 | 0.77 0.2 | 5547 ± 9698 vs. 1708 ± 1891 544 ± 564 vs. 765 ± 937 | 0.36 0.77 |
E.n. before after | Liczba wykryć-2 vs. 0 Liczba wykryć-3 vs. 0 | Liczba wykryć-2 vs. 0 Liczba wykryć-3 vs. 0 | ||
C.g. before after | 12,261 ± 31,319 vs. 5580 ± 7049 3264 ± 2426 vs. 4867 ± 6646 | 0.45 0.87 | 13,679 ± 31,124 vs. 2272 ± 3107 3336 ± 2366 vs. 4698 ± 6746 | 0.09 0.65 |
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Sender-Janeczek, A.; Zborowski, J.; Szulc, M.; Konopka, T. New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study. Appl. Sci. 2019, 9, 5077. https://doi.org/10.3390/app9235077
Sender-Janeczek A, Zborowski J, Szulc M, Konopka T. New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study. Applied Sciences. 2019; 9(23):5077. https://doi.org/10.3390/app9235077
Chicago/Turabian StyleSender-Janeczek, Aleksandra, Jacek Zborowski, Małgorzata Szulc, and Tomasz Konopka. 2019. "New Local Drug Delivery with Antibiotic in the Nonsurgical Treatment of Periodontitis—Pilot Study" Applied Sciences 9, no. 23: 5077. https://doi.org/10.3390/app9235077