Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography
Abstract
:Featured Application
Abstract
1. Introduction
2. Materials and Methods
2.1. Brain Samples
2.2. OCT and Data Acquisition
2.3. Histology
2.4. Data Processing and Statistical Analysis
3. Results
3.1. Appearance of Plaques in Intensity and Retardation OCT Images
3.2. Comparison of Segmentation and Image Contrast
3.3. Evaluation of Plaque Load and Size Using Multicontrast OCT
3.4. Comparison to Histology
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Gesperger, J.; Lichtenegger, A.; Roetzer, T.; Augustin, M.; Harper, D.J.; Eugui, P.; Merkle, C.W.; Hitzenberger, C.K.; Woehrer, A.; Baumann, B. Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography. Appl. Sci. 2019, 9, 2100. https://doi.org/10.3390/app9102100
Gesperger J, Lichtenegger A, Roetzer T, Augustin M, Harper DJ, Eugui P, Merkle CW, Hitzenberger CK, Woehrer A, Baumann B. Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography. Applied Sciences. 2019; 9(10):2100. https://doi.org/10.3390/app9102100
Chicago/Turabian StyleGesperger, Johanna, Antonia Lichtenegger, Thomas Roetzer, Marco Augustin, Danielle J. Harper, Pablo Eugui, Conrad W. Merkle, Christoph K. Hitzenberger, Adelheid Woehrer, and Bernhard Baumann. 2019. "Comparison of Intensity- and Polarization-based Contrast in Amyloid-beta Plaques as Observed by Optical Coherence Tomography" Applied Sciences 9, no. 10: 2100. https://doi.org/10.3390/app9102100