Variable Expression of Notch1 and Pax5 in Classical Hodgkin Lymphoma and Infection with Epstein–Barr in Pediatric Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Cases
2.2. Epstein–Barr Detection
2.3. Immunohistochemistry of Tissue Microarrays
2.4. Immunostaining
2.5. Variable Definitions
2.6. Statistical Analysis
3. Results
3.1. EBV Detection
3.2. Age at Presentation and Immunophenotype
3.3. NOTCH1 Expression
3.4. PAX5 Expression
4. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Subtype | Total cHL Cases | EBV Status | Reed–Sternberg Cell Counts | ||||
---|---|---|---|---|---|---|---|
Negative | Positive | ||||||
n = 9 | n = 32 | <20 | 21–40 | 41–60 | >61 | ||
NSHL | 16 | 3 | 13 | 7 | 0 | 0 | 6 |
MCHL | 16 | 4 | 12 | 6 | 2 | 0 | 4 |
LDHL | 4 | 0 | 4 | 0 | 0 | 1 | 3 |
NLPHL | 2 | 0 | 2 | 0 | 0 | 0 | 2 |
Not Specified | 3 | 2 | 1 | 1 | 0 | 0 | 0 |
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Palma-Lara, I.; Sánchez-Aldana, A.E.; Jiménez-Hernández, E.; Martínez-Villegas, O.; Núñez-Enríquez, J.C.; Mejía-Aranguré, J.M.; Ochoa, S.A.; Xicohtencatl-Cortes, J.; Cruz-Córdova, A.; Zavala-Vega, S.; et al. Variable Expression of Notch1 and Pax5 in Classical Hodgkin Lymphoma and Infection with Epstein–Barr in Pediatric Patients. Microorganisms 2020, 8, 958. https://doi.org/10.3390/microorganisms8060958
Palma-Lara I, Sánchez-Aldana AE, Jiménez-Hernández E, Martínez-Villegas O, Núñez-Enríquez JC, Mejía-Aranguré JM, Ochoa SA, Xicohtencatl-Cortes J, Cruz-Córdova A, Zavala-Vega S, et al. Variable Expression of Notch1 and Pax5 in Classical Hodgkin Lymphoma and Infection with Epstein–Barr in Pediatric Patients. Microorganisms. 2020; 8(6):958. https://doi.org/10.3390/microorganisms8060958
Chicago/Turabian StylePalma-Lara, Icela, Ana Elena Sánchez-Aldana, Elva Jiménez-Hernández, Octavio Martínez-Villegas, Juan Carlos Núñez-Enríquez, Juan Manuel Mejía-Aranguré, Sara A. Ochoa, Juan Xicohtencatl-Cortes, Ariadnna Cruz-Córdova, Sergio Zavala-Vega, and et al. 2020. "Variable Expression of Notch1 and Pax5 in Classical Hodgkin Lymphoma and Infection with Epstein–Barr in Pediatric Patients" Microorganisms 8, no. 6: 958. https://doi.org/10.3390/microorganisms8060958