Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders
Abstract
:1. Introduction
2. Results
2.1. Neonates
2.2. Malignant and/or Hematologic Disorders
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author (yr) | Postnatal Day | Species | Sex | Site of Isolation | Weight (gr) | Gestation Age (wks) | Medical History | Treatment | Outcome | Country |
---|---|---|---|---|---|---|---|---|---|---|
Noni et al. (2020) | n/a | asahii | F | Catheter | n/a | n/a | Pacemaker insertion, hypotonia | n/a | n/a | Greece |
Basu et al. (2015) | 9 | asahii | M | Blood | 920 | 27 | Prematurity, ELBW, RDS, ventilation, LOS | LAMB | Died | India |
8 | asahii | M | Blood | 980 | 27 | Prematurity, ELBW, RDS, CPAP, LOS | LAMB | Died | India | |
11 | asahii | F | Blood | 900 | 30 | Prematurity, ELBW, LOS | LAMB | Died | India | |
Vashishtha et al. (2012) | 5 | Trichosporon spp. | n/a | Blood | 2890 | Term | MSAF, PNA, gastrointestinal bleeding | AMB | Died | India |
7 | Trichosporon spp. | n/a | Blood | 1550 | 31 | SGA with RDS (HMD), mechanical ventilation | AMB | Died | India | |
n/a | asahii | n/a | Blood | 1235 | 28 | AGA, PNA, PPROM, RDS | AMB | Died | India | |
11 | Trichosporon spp. | n/a | Blood | 1720 | 34 | SGA, BOH. PPROM, NEC | AMB | Alive | India | |
21 | Trichosporon spp. | n/a | Blood | 1080 | 29 | SGA, PNA, PPROM, mechanical ventilation | AMB | Died | India | |
n/a | asahii | n/a | Blood | 1250 | 32 | SGA, PNA, PPROM, RDS, mechanical ventilation, early onset sepsis | AMB | Died | India | |
n/a | asahii | n/a | Blood | 1200 | 35 | SGA, polycythemia, sepsis | AMB | Died | India | |
n/a | asahii | n/a | Blood | 2400 | Term | SGA, PNA, sepsis | AMB | Alive | India | |
Pereira et al. (2009) | n/a | asahii | M | Blood | 815 | 29 | RDS, mechanical ventilation | n/a | Died | Brazil |
Chagas-Neto et al. (2009) | 16 | asahii | F | Blood | n/a | n/a | Prematurity | AMB | Died | Brazil |
84 | asahii | M | Blood | n/a | n/a | Premature birth, enterectomy | FLC+AMB | Alive | Brazil | |
Tellez-Castillo et al. (2008) | n/a | asahii | n/a | Endovascular catheter, tube | 685 | 24 | Prematurity, sepsis, mechanical ventilation | n/a | Died | Spain |
Maheshwari et al. (2004) | 26 | asahii | F | Blood | 737 | 24 | RDS, mechanical ventilation, PDA, sepsis | AMB + 5-FC | Alive | USA |
Yildiran et al. (2003) | 21 | asahii | F | Blood, urine | 1050 | 27 | Prematurity, RDS, LOS | AMB | Alive | Turkey |
Salazar et al. (2002) | 15 | beigelii | M | Blood, tracheal aspirate | 960 | 27 | RDS, mechanical ventilation, sepsis | AMB | Died | USA |
17 | asahii | M | Peritoneal fluid, blood, urine | 720 | 24 | RDS, mechanical ventilation, PPROM | AMB | Died | USA | |
Panagopoulou et al. (2002) | 6 | asahii | F | Blood | 890 | 26 | RDS, LOS | AMB | Alive | Greece |
Sweet et al. (1998) | 16 | beigelii | F | Tracheal aspirate, peritoneal fluid, skin, urine | 950 | 25 | RDS, PPROM | LAMB | Alive | United Kingdom |
Yoss et al. (1997) | 10 | beigelii | M | Blood, umbilical catheter, tracheal aspirate | 530 | 23 | RDS, sepsis, mechanical ventilation | AMB | Died | USA |
10 | beigelii | F | Urine, tracheal aspirate, umbilical catheter | 545 | 23 | RDS, mechanical ventilation, sepsis | AMB | Died | USA |
Study (Year) | Sex, Age (yrs) | Underlying Disease | ANC<500 | Site of Isolation | Antifungal Prophylaxis | Empirical Antifungal Treatment | Treatment | Outcome | Country |
---|---|---|---|---|---|---|---|---|---|
Noni et al. (2020) | F, 2.5 | Yolk sac tumor | n/a | Blood | n/a | n/a | n/a | n/a | Greece |
M, 14 | Relapsed ALL after BMT | n/a | Blood | n/a | n/a | n/a | n/a | Greece | |
F, 10 | ALL | n/a | Pleural fluid | n/a | n/a | n/a | n/a | Greece | |
n/a, 10 | Blackfan-Diamond | n/a | Blood, Bronchial secretion | n/a | n/a | n/a | n/a | Greece | |
Raju et al. (2019) | M, 1 | Wilms | YES | Blood | n/a | n/a | VRC | Alive | India |
Galligan et al. (2018) | M,18 | Relapsed ALL | n/a | Blood, Skin | MCF | AMB, VRC | VRC | Died of ALL | USA |
Lee Yuexian et al. (2017) | F, 4 | Aplastic anemia | YES | Skin | CAS | LAMB | VRC | Alive | Singapore |
Nguyen et al. (2017) | M, 10 | High-risk ALL | YES | Lung, heart, kidney, spleen, lymph nodes | MFG | LAMB | VRC | Died | USA |
Foster et al. (2016) | M, 10 | ALL | YES | Blood, lung | MFG | LAMB | LAMB, VRC | Died | USA |
F, 15 | ALL | YES | Skin | MFG | LAMB | LAMB, VRC | Alive | USA | |
F, 8 | ALL | YES | Skin | MFG | LAMB, VCZ | LAMB, VRC | Alive | USA | |
Maxfield et al. (2015) | F, 3 | ALL | n/a | Blood, Urine, Skin | n/a | VCZ, MCF | LAMB, VRC | Died of other cause | USA |
Oh et al. (2015) | M, 3 | Mixed ALL/AML | YES | Skin | n/a | MCF | AMB, POS | Alive | USA |
Tanyildiz et al. (2015) | M, 2 | LCH | YES | Blood | n/a | LAMB | VRC | Alive | Turkey |
F, 12 | Secondary AML | YES | Blood | n/a | LAMB | VRC | Alive | Turkey | |
Karapinar et al. (2014) | F,16 | Aplastic anemia | YES | Blood | n/a | CAS | VRC | Died | Turkey |
F, 5 | ALL | YES | Blood | n/a | CAS | VRC | Alive | Turkey | |
Agarwal and Joyce (2014) | n/a, 12 | AML | YES | Blood | FLC | n/a | n/a | Died | USA |
n/a, 12 | AML | YES | Blood | CAS | n/a | n/a | Died | USA | |
n/a, 12 | AML | YES | Urine | MFG | n/a | n/a | n/a | USA | |
n/a, 12 | AML | YES | Urine | VCZ, MFG | n/a | n/a | n/a | USA | |
n/a, 13 | AML | YES | Blood | VCZ | n/a | n/a | Died | USA | |
n/a, 14 | AML | YES | Blood | MFG | n/a | n/a | n/a | USA | |
Parlakay et al. (2013) | M, 16 | Ewing | n/a | Blood, Conchae, nose | n/a | LAMB, CAS, | LAMB | Died | Turkey |
Kudo et al. (2011) | F, 0.4 | AML | YES | Blood | AMB | MFG | VCZ | Alive | Japan |
Thibeault et al. (2008) | M, 11 | ALL | YES | Blood, liver, urine | n/a | L-AMB | VCZ | Died | Canada |
Tsuji et al. (2008) | M,16 | ALL | NO | Blood, urine | MFG | VRC | VCZ | Died of other cause | Japan |
Hosoki et al. (2008) | M, 18 | MDS | n/a | Blood | AMB, ITC | LAMB, ITC | LAMB, ITC | Died of other cause | Japan |
Ghiasian et al. (2006) | F, 11 | Aplastic anemia | YES | Blood, sputum, oral lesions | n/a | AMB | AMB | Died | Iran |
Antachopoulos et al. (2005) | M, 13 | ALL | YES | Blood, BAL | AMB | LAMB | LAMB, VCZ | Died of other cause | Greece |
Meyer et al. (2002) | n/a, 13 | Mixed ALL/AML | YES | Blood, liver | n/a | AMB | ITC | Alive | France |
Itoh et al. (1996) | F, 5 | ALL | YES | Blood, skin | n/a | n/a | MFG | Died | Japan |
Study (Year) | Species | AMPB | 5-FC | Fluconazole | Itraconazole | Voriconazole | Posaconazole | Caspofungin | Micafungin | Anidulafungin |
---|---|---|---|---|---|---|---|---|---|---|
Noni et al. (2020) | Yolk sac | 0.125 | 8 | 4 | 0.03 | 0.01 | 0.031 | 8 | 8 | 8 |
Relapsed ALL after BMT | 8 | 8 | 6 | 0.031 | 0.031 | 0.25 | 16 | 8 | 8 | |
ALL | 1 | 8 | 32 | 0.06 | 0.06 | 0.125 | 4 | 8 | 8 | |
Blackfan-Diamond | 6 | 8 | 16 | 4 | 0.19 | 0.031 | 8 | 8 | 8 | |
Raju et al. (2019) | Wilms | sens | n/a | sens | n/a | 0.06 | n/a | n/a | n/a | n/a |
Galligan et al. (2018) | Relapsed ALL | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Lee Yuexian et al. (2017) | Aplastic anemia | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nguyen et al. (2017) | High-risk ALL | n/a | n/a | n/a | n/a | ≤0.03 | n/a | n/a | n/a | n/a |
Foster et al. (2016) | ALL | 2 | n/a | 0.5 | 0.5 | ≤0.03 | 0.06 | >8 | >8 | >8 |
ALL | 1 | n/a | 4 | 0.5 | 0.125 | 0.25 | >8 | >8 | >8 | |
ALL | 1 | n/a | 2 | 0.5 | 0.06 | 0.125 | ≥8 | ≥8 | >8 | |
Maxfield et al. (2015) | ALL | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Oh et al. (2015) | Mixed ALL/AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tanyildiz et al. (2015) | LCH | 1 | n/a | 0.50 | 0.125 | 0.03 | 0.25 | 4 | n/a | 2 |
Secondary AML | 1 | n/a | 0.5 | 0.25 | 0.06 | 0.5 | 3 | n/a | 3 | |
Karapinar et al. (2014) | Aplastic anemia | 1.5 | n/a | 3 | 0.032 | 0.094 | n/a | >32 | n/a | n/a |
ALL | 0.008 | n/a | 0.023 | 0.25 | 0.023 | n/a | >32 | n/a | n/a | |
Agarwal and Joyce (2014) | AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
AML | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
Parlakay et al. (2013) | Ewing | n/a | n/a | 4 | n/a | 0.03 | n/a | n/a | n/a | n/a |
Kudo et al. (2011) | AML | 2 | >64 | 4 | 1 | 0.125 | n/a | n/a | >16 | n/a |
Thibeault et al. (2008) | ALL | 8 | n/a | 1 | n/a | 0.03 | n/a | >8 | n/a | n/a |
Tsuji et al. (2008) | ALL | 0.5 | n/a | 1 | 0.25 | 0.25 | n/a | >16 | n/a | |
Hosoki et al. (2008) | MDS | 2 | >128 | >128 | 2 | ≥32 | ||||
Ghiasian et al. (2006) | Aplastic anemia | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Antachopoulos et al. (2005) | ALL | 0.25 | n/a | 4 | 0.5 | 0.125 | 0.5 | n/a | n/a | n/a |
Meyer et al. (2002) | Mixed ALL/AML | 0.032 | n/a | 2 | 2 | n/a | n/a | n/a | n/a | n/a |
Itoh et al. (1996) | ALL | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Median MIC (pediatric studies) | 1 | 8 | 3.5 | 0.375 | 0.06 | 0.187 | 8 | 8 | 8 |
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Kourti, M.; Roilides, E. Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders. Pathogens 2022, 11, 242. https://doi.org/10.3390/pathogens11020242
Kourti M, Roilides E. Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders. Pathogens. 2022; 11(2):242. https://doi.org/10.3390/pathogens11020242
Chicago/Turabian StyleKourti, Maria, and Emmanuel Roilides. 2022. "Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders" Pathogens 11, no. 2: 242. https://doi.org/10.3390/pathogens11020242