Normal Lung Tissue CT Density Changes after Volumetric-Arc Radiotherapy (VMAT) for Lung Cancer
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Characteristics
2.2. Software Workflow and Data Analysis
3. Results
3.1. Lung Density Changes in the Function of Dose
3.2. Time Evolution of Lung Density Changes
3.3. Factors Influencing Density Changes Degree
3.3.1. Clinical Factors Influencing the Early Phase (3–6 Months)
3.3.2. Clinical Factors Influencing the Late Phase (over 12 Months)
3.3.3. DCT Ventilation
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Patients’ Characteristics | Treatment Characteristics | ||
---|---|---|---|
Total number of pts. | 47 | Mean total dose (Gy) | 57 (30–66) |
Median age | 66 (52–82) | Fraction dose (2 Gy/3 Gy) | 34/13 |
Women/men | 20/27 | Mean PTV volume (cm3) | 217 (47–645) |
NSCLC/SCLC | 43/4 | Mean V5_lung (%) | 46 (12–71.7) |
Preceding surgery (yes/no) | 13/34 | Mean V20_lung (%) | 17.2 (4.6–31) |
Sequential chemo (yes/no) | 37/10 | Mean lung doses (Gy) | 10.36 (3.4–16.5) |
Chemo type | PN (27), KN (4), PE (3), KE (2), NVB mono (1) | Mean V5_heart (%) | 37.43 (0–93.5) |
Total number of follow-up CTs | 120 | Mean V40_heart | 3.53 (0–14.8) |
Time distribution of follow-up CTs 1 | 0–3 m (12), 3–6 m (30), 6–9 m (18), 9–12 m (26), 12–18 m (22), 18 m+ (11) | Mean heart doses (Gy) | 7.86 (0.124–23) |
Comorbidities 2 | COPD (10), AH (24), DM (8) | ||
Rad. pneumonitis 3 | G1 (0), G2 (2), G3+ (0) |
Time from RT | ΔHUmax (HU) | D50 | D95 | γ | R2 |
---|---|---|---|---|---|
0–3 months | 96 (85.5–106.5) | 38.6 Gy | 70.2 Gy | 0.76 | 0.98 |
3–6 months | 64.1 (50.1–78) | 18.9 Gy | 38.4 Gy | 0.71 | 0.94 |
6–9 months | 39.9 (36.6–43.1) | 23.7 Gy | 36.4 Gy | 1.36 | 0.99 |
9–12 months | 25.4 (14.4–36.4) | 14.3 Gy | 31.6 Gy | 0.61 | 0.80 |
12–18 months | 45.2 (36.7–53.7) | 21.9 Gy | 45.1 Gy | 0.69 | 0.96 |
Over 18 months | 57.1 (48.8–65.4) | 25.1 Gy | 53 Gy | 0.66 | 0.97 |
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Konkol, M.; Bryl, M.; Fechner, M.; Matuszewski, K.; Śniatała, P.; Milecki, P. Normal Lung Tissue CT Density Changes after Volumetric-Arc Radiotherapy (VMAT) for Lung Cancer. J. Pers. Med. 2022, 12, 485. https://doi.org/10.3390/jpm12030485
Konkol M, Bryl M, Fechner M, Matuszewski K, Śniatała P, Milecki P. Normal Lung Tissue CT Density Changes after Volumetric-Arc Radiotherapy (VMAT) for Lung Cancer. Journal of Personalized Medicine. 2022; 12(3):485. https://doi.org/10.3390/jpm12030485
Chicago/Turabian StyleKonkol, Marek, Maciej Bryl, Marek Fechner, Krzysztof Matuszewski, Paweł Śniatała, and Piotr Milecki. 2022. "Normal Lung Tissue CT Density Changes after Volumetric-Arc Radiotherapy (VMAT) for Lung Cancer" Journal of Personalized Medicine 12, no. 3: 485. https://doi.org/10.3390/jpm12030485