Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation—A Case Report and Review of the Literature
Abstract
:1. Introduction
2. Materials and Methods
3. Case Presentation
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Author | Age | Gender | Tumour Location | Immunohistochemistry | Genetics |
---|---|---|---|---|---|
Ramos-Rodríguez G. et al. [22] | 59 | Male | Thigh | Positive: S100, HMB45, MiTF1, D2-40 Negative: CD31, p63, AE1/AE3 Ki-67: 5–10% | N/A |
Ambrogio F. et al. [23] | 87 | Male | Cutaneous | Differentiated component:
| BRAF V600E mutation |
Fonda-Pascual P. et al. [24] | 63 | Female | Scapular region | Positive: S100, SOX9, HMB45 Negative: AE1/AE3, D2-40, CD31 | BRAF V600E mutation |
Baron J.A. et al. [25] | 84 | Male | Forehead | Positive: S100 Negative: HMB45 | N/A |
Adler M.J. et al. [26] | 44 | Male | Forehead metastases | Positive: S100, HMB 45, and vimentin | N/A |
Zelger B.G. et al. [27] | 56 | Female | Subcutaneous metastases | Positive: S100, HMB45, MelanA, CD56 | N/A |
61 | Male | Axillary lymph node metastases | Positive: S100, CD56 | N/A | |
Kilsdonk M.J. et al. [15] | 69 | Male | Inguinal lymph node metastases | Differentiated component:
| NRAS c.181_182delinsAG p mutation |
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Dumitru, A.V.; Țăpoi, D.A.; Costache, M.; Ciongariu, A.M.; Ionescu, A.I.; Liscu, H.D.; Alius, C.; Tampa, M.; Marin, A.; Furtunescu, A.R. Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation—A Case Report and Review of the Literature. Diagnostics 2024, 14, 1323. https://doi.org/10.3390/diagnostics14131323
Dumitru AV, Țăpoi DA, Costache M, Ciongariu AM, Ionescu AI, Liscu HD, Alius C, Tampa M, Marin A, Furtunescu AR. Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation—A Case Report and Review of the Literature. Diagnostics. 2024; 14(13):1323. https://doi.org/10.3390/diagnostics14131323
Chicago/Turabian StyleDumitru, Adrian Vasile, Dana Antonia Țăpoi, Mariana Costache, Ana Maria Ciongariu, Andreea Iuliana Ionescu, Horia Dan Liscu, Catalin Alius, Mircea Tampa, Andrei Marin, and Andreea Roxana Furtunescu. 2024. "Metastatic Nodular Melanoma with Angiosarcomatous Transdifferentiation—A Case Report and Review of the Literature" Diagnostics 14, no. 13: 1323. https://doi.org/10.3390/diagnostics14131323