Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype
Abstract
:1. Introduction
2. Materials and Methods
2.1. Geometry
2.2. Computational Model Set-Up
2.2.1. Numerical Mesh
2.2.2. Computational Algorithm
2.2.3. Hemolysis Model
2.3. Empirical Experiment Set-Up
2.4. Data Analysis
3. Results
3.1. Simulation: Hemolysis
3.2. Empirical: Hemolysis
3.3. Empirical vs. Simulation Hemolysis
4. Discussion
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Research Group | Channel Dimension | Nominal Device Flow Rate (mL/min) | Flow Rate per Layer (mL/min) | Single Channel Flow Rate (mL/min) | Max. Wall Shear Stress (Pa) | Calculated Shear Rate (1/s) | ||
---|---|---|---|---|---|---|---|---|
Height (µm) | Width (µm) | Length (mm) | ||||||
Borenstein [38,39] | 160 | 500 | 91 | 750 | 94 ** | 0.136 | 3.5 | 1170 |
Potkay [40] | 200 | 297 | 7.3 | 6 | 6 | 0.03 | 3.3 | 1100 |
Selvaganapathy [12] | 160 | 1000 | 91 | 60 | 7.5 ** | 1.1 * | 6 | 2000 |
Baseline | Reduced Port | Reduced Gap | Herringbone | Positive Control | Negative Control | |
---|---|---|---|---|---|---|
# of Channels | 5 | 5 | 2 | 5 | ||
Channel Width (mm) | 1.6 | 1.6 | 1.6 | 1.6 | ||
Channel Height (mm) | 2.8 | 2.8 | 0.25 | 2.8 | ||
Channel Length (mm) | 20 | 20 | 20 | 20 | 30 | 50 |
Port ID (device) | 1.6 | 1 | 1.6 | 1.6 | 0.4 | 1.6 |
# Herringbones/channel | 0 | 0 | 0 | 12 |
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© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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Imtiaz, N.; Poskus, M.D.; Stoddard, W.A.; Gaborski, T.R.; Day, S.W. Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype. Micromachines 2024, 15, 790. https://doi.org/10.3390/mi15060790
Imtiaz N, Poskus MD, Stoddard WA, Gaborski TR, Day SW. Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype. Micromachines. 2024; 15(6):790. https://doi.org/10.3390/mi15060790
Chicago/Turabian StyleImtiaz, Nayeem, Matthew D. Poskus, William A. Stoddard, Thomas R. Gaborski, and Steven W. Day. 2024. "Empirical and Computational Evaluation of Hemolysis in a Microfluidic Extracorporeal Membrane Oxygenator Prototype" Micromachines 15, no. 6: 790. https://doi.org/10.3390/mi15060790