The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review
Abstract
:1. Introduction
2. Mechanism of Anticancer Chemotherapy Toxicity
Anticancer Agents | ||
---|---|---|
Type | Drug | References |
Alkylating Agents | Cisplatin | [37] |
Temozolomide | [38] | |
Busulfan | [39] | |
Ifosfamide | [40] | |
Cyclophosphamide | [41] | |
Protein Kinase Inhibitors | Duvelisib | [42] |
Crizotinib | [43] | |
Lenvatinib | [44] | |
Olaparib | [45] | |
Monoclonal Antibodies | Necitumumab | [46] |
Rituximab | [47] | |
Durvalumab | [48] | |
Moxetumomab | [49] | |
Antibiotics | Bleomycin | [50] |
Idarubicin | [51] | |
Valrubicin | [52] | |
Daunorubicin | [53] | |
Doxorubicin | [7] | |
Vinca Alkaloids | Vinblastine | [54] |
Vincristine | [55] | |
Vinorelbine | [56] | |
Hormonal Agents | Flutamide | [57] |
Cyproterone | [58] | |
Triptorelin | [59] | |
Tamoxifen | [60] | |
Antimetabolites | Methotrexate | [61] |
Fluorouracil | [62] | |
Mercaptopurine | [63] | |
Azacitidine | [64] | |
Taxanes | Paclitaxel | [65] |
Docetaxel | [65] | |
Cabazitaxel | [65] | |
Others | Omacetaxine | [66] |
Tazemetostat | [67] | |
Lenalidomide | [68] | |
Thalidomide | [69] |
3. Honey: A Natural Food Product
3.1. Geographical Heterogeneity of Honey
3.2. Natural Compounds in Honey and Their Bioactivity
3.3. Honey and Its Pharmacological Properties
Honey | Origin | Components | Bioactivity | Reference |
---|---|---|---|---|
Tualang honey | Malaysia | Neurotransmitters (choline and acetylcholine) | Anti-depressant | [142] |
Thyme honey | Greece | H2O2 activity and low acidity | Anti-microbial | [143] |
Sidr honey | Kingdom of Saudi Arabia and Pakistan | Polyphenols (caffeic acid and its phenyl esters) | Anticancer | [144] |
Heather honey | Romania | Phenolics | Antibacterial | [145] |
Avocado honey | Spain | o-vanillin, ellagic acid, ferulic acid, and hydroxycinnamic acid | Anti-Alzheimer’s | [146] |
Buckwheat honey | United States | Sugar | Antibacterial | [147] |
Agastache honey | Australia | Phenol, 2,4-bis(1,1-dimethylethyl) | Antifungal | [148] |
Aroeira honey | Brazil | Phenolics | Antifungal | [149] |
Tupelo honey | United States | Sugars | Antimutagenic | [150] |
Sage honey | United States | Sugars (lactulose, lactitol, and inulin) | Prebiotic effect | [83] |
Buckwheat honey | United States | Sugars | Antibacterial | [147] |
Safflower honey | China | Polyphenolics (protocatechuic acid, naringin, gallic acid, myricetin, and quercetin) | Anti-inflammatory | [151] |
Sourwood honey | Malaysia | Phenolics, flavonoids and ascorbic acid | Antioxidant | [152] |
Gelam honey | Malaysia | Amino acids (glycine, methionine, arginine, and proline) | Wound healing | [153] |
Malicia honey | Brazil | Phenolics (procyanidins B1 and B2, epicatechin, and naringin) | Anxiolytic | [154] |
Rhododendron honey | Turkey | Flavanones (hesperetin and luteolin) | Gastrointestinal protective | [155] |
Manuka honey | New Zealand | Organic compound (methyl glyoxal) | Antibacterial properties | [156] |
Red clover honey | Croatia | Volatile compounds (lilac aldehyde, phenylacetaldehyde, and benzaldehyde) | Anti-diabetic | [157] |
Litchi honey | India | Protein (Major Royal Jelly Protein 1) | Anti-proliferative | [78] |
Kanuka honey | New Zealand | Non-volatile compounds (syringic acid, 4-methoxyphenyllactic acid, and methyl syringate) | Anti-viral | [158] |
Sesame honey | India | Phenolic compounds (rutin, apigenin, and quercetin) | Probiotic effects | [159] |
Acacia honey | Malaysia | Flavones and flavanones (acacetin, chrysin, pinocembrin, and epicatechin) | Reduce adiposity and triglyceride levels | [160] |
4. Clinical and Preclinical Evidence on Honey’s Mitigation of AC Toxicity
4.1. Antioxidant Mechanism of Mitigation
4.2. Anti-Inflammatory Mechanism of Mitigation
4.3. Anti-Apoptotic Mechanism of Mitigation
4.4. Immunomodulatory Mechanism of Mitigation
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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Bose, D.; Famurewa, A.C.; Akash, A.; Othman, E.M. The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review. J. Xenobiot. 2024, 14, 1109-1129. https://doi.org/10.3390/jox14030063
Bose D, Famurewa AC, Akash A, Othman EM. The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review. Journal of Xenobiotics. 2024; 14(3):1109-1129. https://doi.org/10.3390/jox14030063
Chicago/Turabian StyleBose, Debalina, Ademola C. Famurewa, Aman Akash, and Eman M. Othman. 2024. "The Therapeutic Mechanisms of Honey in Mitigating Toxicity from Anticancer Chemotherapy Toxicity: A Review" Journal of Xenobiotics 14, no. 3: 1109-1129. https://doi.org/10.3390/jox14030063