A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups
Abstract
:1. Introduction
2. Materials and Methods
2.1. Description of the Dataset
2.2. Data Preprocessing
2.3. Data Analysis
3. Results and Discussion
3.1. P72 Sequences on NCBI
3.2. Examination of All the Full-Length p72 Sequences within the p72 ORF in the Database
3.3. Determining Grouping of p72 according to the Amino Acid Sequence
3.4. Analysis of Partial p72 Sequences Available on NCBI
3.5. ASFV Can Be Classified into Six Genotypes
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Genotype 2 | Genotype 1 | Genotype 8 | Genotype 9 | Genotype 15 | Genotype 23 | |
---|---|---|---|---|---|---|
Genotype 2 | 1.9 | 4.9 | 11.0 | 14.4 | 10.0 | 18.2 |
Genotype 1 | 4.9 | 2.0 | 12.0 | 13.8 | 11.0 | 17.5 |
Genotype 8 | 11.0 | 12.0 | 0 | 11.3 | 3.0 | 16.5 |
Genotype 9 | 14.4 | 13.8 | 11.3 | 2.17 | 12.3 | 6.8 |
Genotype 15 | 10.0 | 11.0 | 3 | 12.3 | 0.0 | 17.5 |
Genotype 23 | 18.2 | 17.5 | 16.5 | 6.8 | 17.5 | 1.0 |
New Genotype Assignment | Historical Genotype |
---|---|
1 | I, VII, and XXII |
2 | II, III, IV, V, XVII, XX, XXI, and XXIV |
8 | VIII |
9 | IX and X |
15 | XV |
23 | XXIIIa and XXIIIb |
New Genotype | Number of Isolates | Number of Unique Sequences |
---|---|---|
1 | 142 | 18 |
2 | 224 | 34 |
8 | 5 | 3 |
9 | 297 | 30 |
15 | 4 | 2 |
23 | 10 | 5 |
1 or 2 | 1840 | 116 |
1 or 2 or 8 | 1 | 1 |
1 or 2 or 8 or 9 or 15 | 1 | 1 |
1 or 2 or 8 or 9 or 23 | 1 | 1 |
1 or 2 or 9 or 23 | 4 | 1 |
1 or 8 or 9 or 2 or 15 | 1 | 1 |
1 or 9 or 23 | 2 | 1 |
2 or 9 | 1 | 1 |
8 or 15 | 72 | 12 |
8 or 9 or 15 | 1 | 1 |
9 or 23 | 31 | 4 |
not defined | 15 | 14 |
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Spinard, E.; Dinhobl, M.; Tesler, N.; Birtley, H.; Signore, A.V.; Ambagala, A.; Masembe, C.; Borca, M.V.; Gladue, D.P. A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups. Viruses 2023, 15, 2246. https://doi.org/10.3390/v15112246
Spinard E, Dinhobl M, Tesler N, Birtley H, Signore AV, Ambagala A, Masembe C, Borca MV, Gladue DP. A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups. Viruses. 2023; 15(11):2246. https://doi.org/10.3390/v15112246
Chicago/Turabian StyleSpinard, Edward, Mark Dinhobl, Nicolas Tesler, Hillary Birtley, Anthony V. Signore, Aruna Ambagala, Charles Masembe, Manuel V. Borca, and Douglas P. Gladue. 2023. "A Re-Evaluation of African Swine Fever Genotypes Based on p72 Sequences Reveals the Existence of Only Six Distinct p72 Groups" Viruses 15, no. 11: 2246. https://doi.org/10.3390/v15112246