Virology, Epidemiology, Pathogenesis, and Control of COVID-19
Abstract
:1. Introduction
2. Virology
2.1. Origin, Classification, and Genome
2.2. Physicochemical Properties
2.3. Receptor Interactions and Cell Entry
2.4. Evolutionary Insights into the Ecology of SARS-CoV-2
2.5. Genomic Variation
3. Epidemiology
3.1. Source of Infection
3.2. Spectrum of Infection
3.3. Clinical Features
3.4. Epidemiological Characteristics in Mainland China
3.5. Other Regions
3.6. Routes of Transmission
3.7. Herd Susceptibility
3.8. High-Risk Population
4. Diagnosis
4.1. Nucleic Acid Test
4.2. Serologic Diagnosis
4.3. CRISPR/Cas13 System
4.4. Imaging Technology
5. Pathogenesis
5.1. Virus Entry and Spread
5.2. Pathological Findings
5.3. Acute Respiratory Distress Syndrome (ARDS)
5.4. Cytokine Storm
5.5. Immune Dysfunction
6. Potential Therapeutics
6.1. Type I IFNs
6.2. Potential Antiviral Compounds
6.3. Convalescent Plasma
6.4. Protective Monoclonal Antibody
6.5. Others
7. Vaccine Development
8. Conclusions and Perspective
Author Contributions
Funding
Conflicts of Interest
References
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Jin, Y.; Yang, H.; Ji, W.; Wu, W.; Chen, S.; Zhang, W.; Duan, G. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 2020, 12, 372. https://doi.org/10.3390/v12040372
Jin Y, Yang H, Ji W, Wu W, Chen S, Zhang W, Duan G. Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses. 2020; 12(4):372. https://doi.org/10.3390/v12040372
Chicago/Turabian StyleJin, Yuefei, Haiyan Yang, Wangquan Ji, Weidong Wu, Shuaiyin Chen, Weiguo Zhang, and Guangcai Duan. 2020. "Virology, Epidemiology, Pathogenesis, and Control of COVID-19" Viruses 12, no. 4: 372. https://doi.org/10.3390/v12040372