The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies
Abstract
:1. Introduction
2. Pharmacodynamics and Pharmacokinetics of Dobutamine
3. Effects of Dobutamine in Normal Subjects
3.1. Cardiovascular Effects
3.2. Metabolic Effects
4. Effects of Dobutamine in Cardiac Failure
5. Effects of Dobutamine in Septic Shock
5.1. Diagnostic Use for Assessing the Metabolic Response
5.2. Effects on Systemic Hemodynamics and Tissue Perfusion
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Scheeren, T.W.; Bakker, J.; Kaufmann, T.; Annane, D.; Asfar, P.; Boerma, E.C.; Cecconi, M.; Chew, M.S.; Cholley, B.; Cronhjort, M.; et al. Current use of inotropes in circulatory shock. Ann. Intensive Care 2021, 11, 21. [Google Scholar] [CrossRef] [PubMed]
- Evans, L.; Rhodes, A.; Alhazzani, W.; Antonelli, M.; Coopersmith, C.M.; French, C.; Machado, F.R.; Mcintyre, L.; Ostermann, M.; Prescott, H.C.; et al. Surviving sepsis campaign: International guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021, 47, 1181–1247. [Google Scholar] [CrossRef] [PubMed]
- Jia, L.; Wang, P.; Li, C.; Xie, J. The efficacy and safety of vasopressors for septic shock patients: A systemic review and network meta-analysis. Shock 2023, 60, 746–752. [Google Scholar] [CrossRef] [PubMed]
- Tacon, C.L.; McCaffrey, J.; Delaney, A. Dobutamine for patients with severe heart failure: A systematic review and meta-analysis of randomised controlled trials. Intensive Care Med. 2012, 38, 359–367. [Google Scholar] [CrossRef] [PubMed]
- Gao, F.; Zhang, Y. Inotrope Use and Intensive Care Unit Mortality in Patients with Cardiogenic Shock: An Analysis of a Large Electronic Intensive Care Unit Database. Front. Cardiovasc. Med. 2021, 8, 696138. [Google Scholar] [CrossRef] [PubMed]
- Wilkman, E.; Kaukonen, K.; Pettilä, V.; Kuitunen, A.; Varpula, M. Association between inotrope treatment and 90-day mortality in patients with septic shock. Acta Anaesthesiol. Scand. 2013, 57, 431–442. [Google Scholar] [CrossRef]
- Sato, R.; Ariyoshi, N.; Hasegawa, D.; Crossey, E.; Hamahata, N.; Ishihara, T.; Nasu, M.; Devendra, G. Effects of Inotropes on the Mortality in Patients with Septic Shock. J. Intensive Care Med. 2021, 36, 211–219. [Google Scholar] [CrossRef]
- Zhu, Y.; Yin, H.; Zhang, R.; Ye, X.; Wei, J. The effect of dobutamine in sepsis: A propensity score matched analysis. BMC Infect. Dis. 2021, 21, 1151. [Google Scholar] [CrossRef]
- Jellema, W.T.; Groeneveld, A.B.J.; Wesseling, K.H.; Thijs, L.G.; Westerhof, N.; van Lieshout, J.J. Heterogeneity and prediction of hemodynamic responses to dobutamine in patients with septic shock. Crit. Care Med. 2006, 34, 2392–2398. [Google Scholar] [CrossRef]
- Kumar, A.; Schupp, E.; Bunnell, E.; Ali, A.; Milcarek, B.; Parrillo, J. Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock. Crit. Care 2008, 12, R35. [Google Scholar] [CrossRef]
- Enrico, C.; Edul, V.S.K.; Vazquez, A.R.; Pein, M.C.; de la Hoz, R.A.P.; Ince, C.; Dubin, A. Systemic and microcirculatory effects of dobutamine in patients with septic shock. J. Crit. Care 2012, 27, 630–638. [Google Scholar] [CrossRef]
- Adjunctive DobutAmine in sePtic Cardiomyopathy with Tissue Hypoperfusion (ADAPT). Available online: https://clinicaltrials.gov/study/NCT04166331 (accessed on 1 March 2024).
- Dupeyron, J.P.; Pottecher, T.; Haberer, J.P.; Gauthier-Lafaye, J.P. Use of dobutamine in the treatment of septic shock. Anesth. Analg. 1977, 34, 917–927. [Google Scholar]
- Ruffolo, R.R., Jr.; Spradlin, T.; Pollock, G.D.; Waddell, J.; Murphy, P.J. Alpha and beta adrenergic effects of the stereoisomers of dobutamine. J. Pharmacol. Exp. Ther. 1981, 219, 447–452. [Google Scholar]
- Ruffolo, R.R., Jr.; Yaden, E.L. Vascular effects of the stereoisomers of dobutamine. J. Pharmacol. Exp. Ther. 1983, 224, 46–50. [Google Scholar] [PubMed]
- Ruffolo, R.R., Jr.; Messick, K. Systemic hemodynamic effects of dopamine, (±)-dobutamine and the (+)-and (-)-enantiomers of dobutamine in anesthetized normotensive rats. Eur. J. Pharmacol. 1985, 109, 173–181. [Google Scholar] [CrossRef] [PubMed]
- Dubin, A.; Lattanzio, B.; Gatti, L. The spectrum of cardiovascular effects of dobutamine from healthy subjects to septic shock patients. Rev. Bras. Ter. Intensiva 2017, 29, 490–498. [Google Scholar] [CrossRef] [PubMed]
- Kates, R.E.; Leier, C.V. Dobutamine pharmacokinetics in severe heart failure. Clin. Pharmacol. Ther. 1978, 24, 537–541. [Google Scholar] [CrossRef] [PubMed]
- Klem, C.; Dasta, J.F.; Reilley, T.; Flancbaum, L.J. Variability in dobutamine pharmacokinetics in unstable critically ill surgical patients. Crit. Care Med. 1994, 22, 1926–1932. [Google Scholar] [CrossRef] [PubMed]
- Hallik, M.; Ilmoja, M.; Standing, J.F.; Soeorg, H.; Jalas, T.; Raidmäe, M.; Uibo, K.; Köbas, K.; Sõnajalg, M.; Takkis, K.; et al. Population pharmacokinetics and pharmacodynamics of dobutamine in neonates on the first days of life. Br. J. Clin. Pharmacol. 2020, 86, 318–328. [Google Scholar] [CrossRef]
- Unverferth, D.V.; Blanford, M.; Kates, R.E.; Leier, C.V. Tolerance to dobutamine after a 72 hour continuous infusion. Am. J. Med. 1980, 69, 262–266. [Google Scholar] [CrossRef]
- Leier, C.V.; Unverferth, D.V.; Kates, R.E. The relationship between plasma dobutamine concentrations and cardiovascular responses in cardiac failure. Am. J. Med. 1979, 66, 238–242. [Google Scholar] [CrossRef] [PubMed]
- Murphy, P.J.; Williams, T.L.; Kau, D.L. Disposition of dobutamine in the dog. J. Pharmacol. Exp. Ther. 1976, 199, 423–431. [Google Scholar] [PubMed]
- Ruffolo, R.R., Jr.; Messick, K.; Horng, J.S. Interactions of the enantiomers of 3-O-methyldobutamine with alpha- and beta-adrenoceptors in vitro. Naunyn-Schmiedeberg’s Arch. Pharmacol. 1985, 329, 244–252. [Google Scholar] [CrossRef] [PubMed]
- Robie, N.W.; Nutter, D.O.; Moody, C.; Mcnay, J.L. In vivo analysis of adrenergic receptor activity of dobutamine. Circ. Res. 1974, 34, 663–671. [Google Scholar] [CrossRef] [PubMed]
- García, M.I.M.; Jian, Z.; Hatib, F.; Settels, J.J.; Cecconi, M.; Pinsky, M.R. Dynamic Arterial Elastance as a Ventriculo-Arterial Coupling Index: An Experimental Animal Study. Front. Physiol. 2020, 11, 284. [Google Scholar] [CrossRef] [PubMed]
- Ahonen, J.; Aranko, K.; Iivanainen, A.; Maunuksela, E.-L.; Paloheimo, M.; Olkkola, K.T. Pharmacokinetic-pharmacodynamic relationship of dobutamine and heart rate, stroke volume and cardiac output in healthy volunteers. Clin. Drug Investig. 2008, 28, 121–127. [Google Scholar] [CrossRef]
- Pellikka, P.A.; Roger, V.L.; McCully, R.B.; Mahoney, D.W.; Bailey, K.R.; Seward, J.B.; Tajik, A. Normal stroke volume and cardiac output response during dobutamine stress echocardiography in subjects without left ventricular wall motion abnormalities. Am. J. Cardiol. 1995, 76, 881–886. [Google Scholar] [CrossRef] [PubMed]
- Maggs, D.G.; Gallen, I.W.; Fone, K.; Macdonald, I.A. Metabolic heat production and cardiovascular responses to an incremental intravenous infusion of adrenaline in healthy subjects. Clin. Auton. Res. 1994, 4, 131–136. [Google Scholar] [CrossRef]
- Fellows, I.W.; Bennett, T.; Macdonald, I.A. The effect of adrenaline upon cardiovascular and metabolic functions in man. Clin. Sci. 1985, 69, 215–222. [Google Scholar] [CrossRef]
- Green, C.J.; Frazer, R.S.; Underhill, S.; Maycock, P.; Fairhurst, J.A.; Campbell, I.T. Metabolic effects of dobutamine in normal man. Clin. Sci. 1992, 82, 77–83. [Google Scholar] [CrossRef]
- Bhatt, S.; Hutchinson, R.; Tomlinson, B.; Oh, T.; Mak, M. Effect of dobutamine on oxygen supply and uptake in healthy volunteers. Br. J. Anaesth. 1992, 69, 298–303. [Google Scholar] [CrossRef]
- Uusaro, A.; Hartikainen, J.; Parviainen, M.; Takala, J. Metabolic stress modifies the thermogenic effect of dobutamine in man. Crit. Care Med. 1995, 23, 674–680. [Google Scholar] [CrossRef]
- Tuttle, R.R.; Mills, J. Dobutamine: Development of a new catecholamine to selectively increase cardiac contractility. Circ. Res. 1975, 36, 185–196. [Google Scholar] [CrossRef]
- How, O.-J.; Røsner, A.; Kildal, A.B.; Stenberg, T.A.; Gjessing, P.F.; Hermansen, S.E.; Myrmel, T. Dobutamine-norepinephrine, but not vasopressin, restores the ventriculoarterial matching in experimental cardiogenic shock. Transl. Res. 2010, 156, 273–281. [Google Scholar] [CrossRef] [PubMed]
- Vik-Mo, H.; Yasay, G.; Maroko, P.R.; Ribeiro, L.G.T. Comparative effects of dobutamine and corwin, a β1-adrenergic partial agonist, in experimental left ventricular failure. J. Cardiovasc. Pharmacol. 1985, 7, 784–790. [Google Scholar] [CrossRef]
- Kamijo, T.; Tomaru, T.; Miwa, A.Y.; Nakamura, F.; Kido, H.; Sugimoto, T.; Uchida, Y. The effects of dobutamine, propranolol and nitroglycerin on an experimental canine model of congestive heart failure. Jpn. J. Pharmacol. 1994, 65, 223–231. [Google Scholar] [CrossRef]
- Fujigaki, T.; Nakamura, H.; Fukui, S.; Miyako, M.; Haseba, S.; Gotoh, Y. Comparison of the effects of amrinone and dobutamine on hemodynamics and myocardial oxygen balance in dogs with experimental left ventricular failure. J. Cardiothorac. Anesth. 1989, 3, 433–440. [Google Scholar] [CrossRef]
- Argenta, L.C.; Kirsh, M.M.; Bove, E.L.; Cimmino, V.M.; Lucchesi, B.; Straker, J.; Baker, R.; Lee, R.; Sloan, H. A comparison of the hemodynamic effects of inotropic agents. Ann. Thorac. Surg. 1976, 22, 50–57. [Google Scholar] [CrossRef] [PubMed]
- Beregovich, J.; Bianchi, C.; D’Angelo, R.; Diaz, R.; Rubler, S. Haemodynamic effects of a new inotropic agent (dobutamine) in chronic cardiac failure. Br. Heart J. 1975, 37, 629–634. [Google Scholar] [CrossRef]
- Stoner, J.D., 3rd; Bolen, J.L.; Harrison, D.C. Comparison of dobutamine and dopamine in treatment of severe heart failure. Br. Heart J. 1977, 39, 536–539. [Google Scholar] [CrossRef]
- Fowler, M.B.; Timmis, A.D.; Crick, J.P.; Vincent, R.; Chamberlain, D. Comparison of haemodynamic responses to dobutamine and salbutamol in cardiogenic shock after acute myocardial infarction. Br. Med. J. (Clin. Res. Ed.) 1982, 284, 73–76. [Google Scholar] [CrossRef] [PubMed]
- Bihari, D.; Smithies, M.; Gimson, A.; Tinker, J. The effects of vasodilation with prostacyclin on oxygen delivery and uptake in critically Ill patients. N. Engl. J. Med. 1987, 317, 397–403. [Google Scholar] [CrossRef] [PubMed]
- Schaffartzik, W.; Sanft, C.; Schaefer, J.H.; Spies, C. Different dosages of dobutamine in septic shock patients: Determining oxygen consumption with a metabolic monitor integrated in a ventilator. Intensive Care Med. 2000, 26, 1740–1746. [Google Scholar] [CrossRef] [PubMed]
- De Backer, D.; Moraine, J.J.; Berre, J.; Kahn, R.J.; Vincent, J.L. Effects of dobutamine on oxygen consumption in septic patients. Direct versus indirect determinations. Am. J. Respir. Crit. Care Med. 1994, 150, 95–100. [Google Scholar] [CrossRef]
- Razazi, K.; Labbé, V.; Laine, L.; Bedet, A.; Carteaux, G.; de Prost, N.; Boissier, F.; Bagate, F.; Dessap, A.M. Hemodynamic effects and tolerance of dobutamine for myocardial dysfunction during septic shock: An observational multicenter prospective echocardiographic study. Front. Cardiovasc. Med. 2022, 9, 951016. [Google Scholar] [CrossRef] [PubMed]
- Vallet, B.; Chopin, C.; Curtis, S.E.; Dupuis, B.A.; Fourrier, F.; Mehdaoui, H.; Leroy, B.; Rime, A.; Santre, C.; Herbecq, P.; et al. Prognostic value of the dobutamine test in patients with sepsis syndrome and normal lactate values: A prospective, multicenter study. Crit. Care Med. 1993, 21, 1868–1875. [Google Scholar] [CrossRef] [PubMed]
- Rhodes, A.; Lamb, F.J.; Malagon, I.; Newman, P.J.; Grounds, R.M.; Bennett, E.D. A prospective study of the use of a dobutamine stress test to identify outcome in patients with sepsis, severe sepsis, or septic shock. Crit. Care Med. 1999, 27, 2361–2366. [Google Scholar] [CrossRef] [PubMed]
- Gutierrez, G.; Clark, C.; Brown, S.D.; Price, K.; Ortiz, L.; Nelson, C. Effect of dobutamine on oxygen consumption and gastric mucosal pH in septic patients. Am. J. Respir. Crit. Care Med. 1994, 150, 324–329. [Google Scholar] [CrossRef] [PubMed]
- Ronco, J.J.; Fenwick, J.C.; Wiggs, B.R.; Phang, P.T.; Russell, J.A.; Tweeddale, M.G. Oxygen consumption is independent of increases in oxygen delivery by dobutamine in septic patients who have normal or increased plasma lactate. Am. Rev. Respir. Dis. 1993, 147, 25–31. [Google Scholar] [CrossRef]
- Vincent, J.L.; Van Der Linden, P.; Domb, M.; Blecic, S.; Azimi, G.; Bernard, A. Dopamine compared with dobutamine in experimental septic shock: Relevance to fluid administration. Anesth. Analg. 1987, 66, 565–571. [Google Scholar] [CrossRef]
- Regnier, B.; Safran, D.; Carlet, J.; Teisseire, B. Comparative haemodynamic effects of dopamine and dobutamine in septic shock. Intensive Care Med. 1979, 5, 115–120. [Google Scholar] [CrossRef] [PubMed]
- Jardin, F.; Sportiche, M.; Bazin, M.; Bourokba, A.; Margairaz, A. Dobutamine: A hemodynamic evaluation in human septic shock. Crit. Care Med. 1981, 9, 329–332. [Google Scholar] [CrossRef] [PubMed]
- Neviere, R.; Chagnon, J.-L.; Vallet, B.; Lebleu, N.; Marechal, X.; Mathieu, D.; Wattel, F.; Dupuis, B. Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit. Care Med. 1997, 25, 1371–1377. [Google Scholar] [CrossRef]
- Nevière, R.; Mathieu, D.; Chagnon, J.L.; Lebleu, N.; Wattel, F. The contrasting effects of dobutamine and dopamine on gastric mucosal perfusion in septic patients. Am. J. Respir. Crit. Care Med. 1996, 154 Pt 1, 1684–1688. [Google Scholar] [CrossRef] [PubMed]
- Levy, B.; Nace, L.; Bollaert, P.-E.; Dousset, B.; Mallie, J.P.; Larcan, A. Comparison of systemic and regional effects of dobutamine and dopexamine in norepinephrine-treated septic shock. Intensive Care Med. 1999, 25, 942–948. [Google Scholar] [CrossRef]
- Joly, L.-M.; Monchi, M.; Cariou, A.; Chiche, J.-D.; Bellenfant, F.; Brunet, F.; Dhainaut, J.-F. Effects of dobutamine on gastric mucosal perfusion and hepatic metabolism in patients with septic shock. Am. J. Respir. Crit. Care Med. 1999, 160, 1983–1986. [Google Scholar] [CrossRef] [PubMed]
- Levy, B.; Bollaert, P.-E.; Charpentier, C.; Nace, L.; Audibert, G.; Bauer, P.; Nabet, P.; Larcan, A. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: A prospective, randomized study. Intensive Care Med. 1997, 23, 282–287. [Google Scholar] [CrossRef]
- Duranteau, J.; Sitbon, P.; Teboul, J.L.; Vicaut, E.; Anguel, N.; Richard, C.; Samii, K. Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit. Care Med. 1999, 27, 893–900. [Google Scholar] [CrossRef] [PubMed]
- Levy, B.; Bollaert, P.-E.; Lucchelli, J.-P.; Sadoune, L.-O.; Nace, L.; Larcan, A. Dobutamine improves the adequacy of gastric mucosal perfusion in epinephrine-treated septic shock. Crit. Care Med. 1997, 25, 1649–1654. [Google Scholar] [CrossRef]
- Secchi, A.; Wellmann, R.; Martin, E.; Schmidt, H. Dobutamine maintains intestinal villus blood flow during normotensive endotoxemia: An intravital microscopic study in the rat. J. Crit. Care 1997, 12, 137–141. [Google Scholar] [CrossRef]
- Ospina-Tascón, G.A.; Marin, A.F.G.; Echeverri, G.J.; Bermudez, W.F.; Madriñán-Navia, H.; Valencia, J.D.; Quiñones, E.; Rodríguez, F.; Marulanda, A.; Arango-Dávila, C.A.; et al. Effects of dobutamine on intestinal microvascular blood flow heterogeneity and O2 extraction during septic shock. J. Appl. Physiol. 2017, 122, 1406–1417. [Google Scholar] [CrossRef] [PubMed]
- Secchi, A.; Ortanderl, J.M.; Schmidt, W.; Walther, A.; Gebhard, M.M.; Martin, E.; Schmidt, H. Effects of dobutamine and dopexamine on hepatic micro- and macrocirculation during experimental endotoxemia: An intravital microscopic study in the rat. Crit. Care Med. 2001, 29, 597–600. [Google Scholar] [CrossRef]
- Fink, T.; Heymann, P.; Taha-Melitz, S.; Taha, A.; Wolf, B.; Rensing, H.; Volk, T.; Mathes, A.M. Dobutamine pretreatment improves survival, liver function, and hepatic microcirculation after polymicrobial sepsis in rat. Shock 2013, 40, 129–135. [Google Scholar] [CrossRef] [PubMed]
- De Backer, D.; Creteur, J.; Dubois, M.-J.; Sakr, Y.; Koch, M.; Verdant, C.; Vincent, J.-L. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects*. Crit. Care Med. 2006, 34, 403–408. [Google Scholar] [CrossRef]
- McCAIG, D.; Parratt, J. A comparison of the cardiovascular effects of dobutamine and a new dopamine derivative (D4975) during shock induced by E. coli endotoxin. Br. J. Pharmacol. 1980, 69, 651–656. [Google Scholar] [CrossRef] [PubMed]
- Tang, X.; Xu, Y.; Dai, X.; Xing, Y.; Yang, D.; Huang, Q.; Li, H.; Lv, X.; Wang, Y.; Lu, D.; et al. The Long-term Effect of Dobutamine on Intrinsic Myocardial Function and Myocardial Injury in Septic Rats with Myocardial Dysfunction. Shock 2021, 56, 582–592. [Google Scholar] [CrossRef]
- Sakai, M.; Suzuki, T.; Tomita, K.; Yamashita, S.; Palikhe, S.; Hattori, K.; Yoshimura, N.; Matsuda, N.; Hattori, Y. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: Attribution to phosphodiesterase 4 upregulation. Am. J. Physiol. Heart Circ. Physiol. 2017, 312, H1224–H1237. [Google Scholar] [CrossRef]
- Dubin, A.; Murias, G.; Sottile, J.P.; Pozo, M.O.; Barán, M.; Edul, V.S.K.; Canales, H.S.; Etcheverry, G.; Maskin, B.; Estenssoro, E. Effects of levosimendan and dobutamine in experimental acute endotoxemia: A preliminary controlled study. Intensive Care Med. 2007, 33, 485–494. [Google Scholar] [CrossRef]
- Heino, A.; Hartikainen, J.; Merasto, M.E.; Koski, E.M.J.; Tenhunen, J.; Alhava, E.; Takala, J. Effects of dobutamine on splanchnic tissue perfusion during partial superior mesenteric artery occlusion. Crit. Care Med. 2000, 28, 3484–3490. [Google Scholar] [CrossRef]
- Bomberg, H.; Bierbach, B.; Flache, S.; Novák, M.; Schäfers, H.-J.; Menger, M.D. Dobutamine Versus Vasopressin After Mesenteric Ischemia. J. Surg. Res. 2019, 235, 410–423. [Google Scholar] [CrossRef]
- Hiltebrand, L.B.; Krejci, V.; Sigurdsson, G.H. Effects of dopamine, dobutamine, and dopexamine on microcirculatory blood flow in the gastrointestinal tract during sepsis and anesthesia. Anesthesiology 2004, 100, 1188–1197. [Google Scholar] [CrossRef] [PubMed]
- Hayes, M.A.; Timmins, A.C.; Yau, E.; Palazzo, M.; Hinds, C.J.; Watson, D. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N. Engl. J. Med. 1994, 330, 1717–1722. [Google Scholar] [CrossRef]
- Peake, S.L.; Delaney, A.; Bailey, M.; Bellomo, R.; Cameron, P.A.; Cooper, D.J.; Higgins, A.M.; Holdgate, A.; Howe, B.D.; Webb, S.A.; et al. Goal-directed resuscitation for patients with early septic shock. N. Engl. J. Med. 2014, 371, 1496–1506. [Google Scholar]
- ProCESS Investigators; Yealy, D.M.; Kellum, J.A.; Huang, D.T.; Barnato, A.E.; Weissfeld, L.A.; Pike, F. A randomized trial of protocol-based care for early septic shock. N. Engl. J. Med. 2014, 370, 1683–1693. [Google Scholar]
- Mouncey, P.R.; Osborn, T.M.; Power, G.S.; Harrison, D.A.; Sadique, M.Z.; Grieve, R.D.; Jahan, R.; Harvey, S.E.; Bell, D.; Bion, J.F.; et al. Trial of early, goal-directed resuscitation for septic shock. N. Engl. J. Med. 2015, 372, 1301–1311. [Google Scholar] [CrossRef]
- Cariou, A.; Pinsky, M.R.; Monchi, M.; Laurent, I.; Vinsonneau, C.; Chiche, J.D.; Charpentier, J.; Dhainaut, J.F. Is myocardial adrenergic responsiveness depressed in human septic shock? Intensive Care Med. 2008, 34, 917–922. [Google Scholar] [CrossRef] [PubMed]
- Hernandez, G.; Bruhn, A.; Luengo, C.; Regueira, T.; Kattan, E.; Fuentealba, A.; Florez, J.; Castro, R.; Aquevedo, A.; Pairumani, R.; et al. Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: A randomized, placebo-controlled, double-blind, crossover study. Intensive Care Med. 2013, 39, 1435–1443. [Google Scholar] [CrossRef]
- Parker, M.M.; Shelhamer, J.H.; Natanson, C.; Alling, D.W.; Parrillo, J.E. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit. Care Med. 1987, 15, 923–929. [Google Scholar] [CrossRef] [PubMed]
- Sanfilippo, F.; Corredor, C.; Fletcher, N.; Landesberg, G.; Benedetto, U.; Foex, P.; Cecconi, M. Diastolic dysfunction and mortality in septic patients: A systematic review and meta-analysis. Intensive Care Med. 2015, 41, 1004–1013. [Google Scholar] [CrossRef]
- Chauvet, J.-L.; El-Dash, S.; Delastre, O.; Bouffandeau, B.; Jusserand, D.; Michot, J.-B.; Bauer, F.; Maizel, J.; Slama, M. Early dynamic left intraventricular obstruction is associated with hypovolemia and high mortality in septic shock patients. Crit. Care 2015, 19, 262. [Google Scholar] [CrossRef]
- Tano, A.; Kasamaki, Y.; Okumura, Y.; Ohta, M.; Kofune, T.; Fujii, N.; Aizawa, Y.; Nakai, T.; Kunimoto, S.; Hiro, T.; et al. Major determinants and possible mechanism of dobutamine-induced left ventricular outflow tract obstruction in patients with a sigmoid ventricular septum. J. Cardiol. 2013, 61, 428–435. [Google Scholar] [CrossRef]
- Mosley, W.J., 2nd; Manuchehry, A.; McEvoy, C.; Rigolin, V. Takotsubo cardiomyopathy induced by dobutamine infusion: A new phenomenon or an old disease with a new name. Echocardiography 2010, 27, E30–E33. [Google Scholar] [CrossRef]
- Fatima, S.; Mohiuddin, Z.S.; Bage, M.D.; Sul, L. Dobutamine-Induced Takotsubo Cardiomyopathy with Severe Left Ventricular Dysfunction. Cureus 2023, 15, e50390. [Google Scholar] [CrossRef]
- Duan, C.; Yang, G.; Li, T.; Liu, L. Advances in Vascular Hyporeactivity After Shock: The Mechanisms and Managements. Shock 2015, 44, 524–554. [Google Scholar] [CrossRef]
- Landry, D.W.; Oliver, J.A. The pathogenesis of vasodilatory shock. N. Engl. J. Med. 2001, 345, 588–595. [Google Scholar] [CrossRef]
- Bucher, M.; Kees, F.; Taeger, K.; Kurtz, A. Cytokines down-regulate α1-adrenergic receptor expression during endotoxemia. Crit. Care Med. 2003, 31, 566–571. [Google Scholar] [CrossRef]
- Weiss, M.; Arendt, P.; Hassna, R. Effect of disease states on α1-adrenoceptor binding and signal transduction parameters in isolated perfused heart: Quantification by pharmacokinetic-pharmacodynamic modelling. J. Pharm. Pharmacol. 2013, 66, 668–676. [Google Scholar] [CrossRef]
- Tang, C.; Yang, J.; Wu, L.L.; Dong, L.W.; Liu, M.S. Phosphorylation of beta-adrenergic receptor leads to its redistribution in rat heart during sepsis. Am. J. Physiol. 1998, 274 Pt 2, R1078–R1086. [Google Scholar]
- Evans, W.E.; McLeod, H.L. Pharmacogenomics--drug disposition, drug targets, and side effects. N. Engl. J. Med. 2003, 348, 538–549. [Google Scholar] [CrossRef] [PubMed]
- Lymperopoulos, A.; Garcia, D.; Walklett, K. Pharmacogenetics of cardiac inotropy. Pharmacogenomics 2014, 15, 1807–1821. [Google Scholar] [CrossRef] [PubMed]
- Sandilands, A.J.; O’Shaughnessy, K.M.; Brown, M.J. Greater inotropic and cyclic AMP responses evoked by noradrenaline through Arg389 beta 1-adrenoceptors versus Gly389 beta 1-adrenoceptors in isolated human atrial myocardium. Br. J. Pharmacol. 2003, 138, 386–392. [Google Scholar] [CrossRef]
- La Rosée, K.; Huntgeburth, M.; Rosenkranz, S.; Böhm, M.; Schnabel, P. The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines. Pharmacogenetics 2004, 14, 711–716. [Google Scholar] [CrossRef]
- Yogev, D.; Basheer, M.; Blotnick, S.; Caraco, Y.; Muszkat, M. Effects of sex and the common ADRB1 389 genetic polymorphism on the hemodynamic response to dobutamine. Pharmacogenet. Genom. 2015, 25, 555–563. [Google Scholar] [CrossRef]
- Bruck, H.; Leineweber, K.; Temme, T.; Weber, M.; Heusch, G.; Philipp, T.; Brodde, O.-E. The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity. J. Am. Coll. Cardiol. 2005, 46, 2111–2115. [Google Scholar] [CrossRef]
- Hallik, M.; Soeorg, H.; Kahre, T.; Murumets, Ü.; Ilmoja, M.; Kipper, K.; Metsvaht, T. Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates. Br. J. Clin. Pharmacol. 2022, 88, 4155–4162. [Google Scholar] [CrossRef]
- Mao, Y.-M.; Liu, Z.-Q.; Chen, B.-L.; Guo, D.; Han, C.-T.; Yang, L.-J.; Wang, S.-Y.; Fan, L.; Zhou, H.-H. Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects. J. Clin. Pharmacol. 2009, 49, 929–936. [Google Scholar] [CrossRef]
- Aquilante, C.L.; Yarandi, H.N.; Cavallari, L.H.; Andrisin, T.E.; Terra, S.G.; Lewis, J.F.; Hamilton, K.K.; Johnson, J.A. Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography. Pharmacogenom. J. 2008, 8, 408–415. [Google Scholar] [CrossRef]
- Tezini, G.C.; Becari, C.; Zanotto, C.Z.; Salgado, M.C.O.; Passaglia, R.d.C.A.T.; Souza, H.C. Ageing is the main determinant of haemodynamics and autonomic cardiac changes observed in post-menopausal female rats. Auton. Neurosci. 2013, 174, 36–41. [Google Scholar] [CrossRef]
- Hees, P.S.; Fleg, J.L.; Mirza, Z.A.; Ahmed, S.; Siu, C.O.; Shapiro, E.P. Effects of normal aging on left ventricular lusitropic, inotropic, and chronotropic responses to dobutamine. J. Am. Coll. Cardiol. 2006, 47, 1440–1447. [Google Scholar] [CrossRef] [PubMed]
- Soto, P.F.; Herrero, P.; Kates, A.M.; Dence, C.S.; Ehsani, A.A.; Dávila-Román, V.; Schechtman, K.B.; Gropler, R.J. Impact of aging on myocardial metabolic response to dobutamine. Am. J. Physiol. Heart Circ. Physiol. 2003, 285, H2158–H2164. [Google Scholar] [CrossRef] [PubMed]
- Poldermans, D.; Boersma, E.; Fioretti, P.M.; van Urk, H.; Boomsma, F.; Man in ‘t Veld, A.J. Cardiac chronotropic responsiveness to beta-adrenoceptor stimulation is not reduced in the elderly. J. Am. Coll. Cardiol. 1995, 25, 995–999. [Google Scholar] [CrossRef]
- Ahtarovski, K.A.; Iversen, K.K.; Lønborg, J.T.; Madsen, P.L.; Engstrøm, T.; Vejlstrup, N. Left atrial and ventricular function during dobutamine and glycopyrrolate stress in healthy young and elderly as evaluated by cardiac magnetic resonance. Am. J. Physiol. Heart Circ. Physiol. 2012, 303, H1469–H1473. [Google Scholar] [CrossRef]
- Jeevanantham, V.; Chughtai, H.; Little, W.C.; Morgan, T.; Kitzman, D.W.; Hamilton, C.A.; Hundley, W.G. Aging reduces left atrial performance during adrenergic stress in middle aged and older patients. Cardiol. J. 2012, 19, 45–52. [Google Scholar] [CrossRef]
- Fischer, M.; Moralez, G.; Sarma, S.; MacNamara, J.P.; Cramer, M.N.; Huang, M.; Romero, S.A.; Hieda, M.; Shibasaki, M.; Ogoh, S.; et al. Altered cardiac β1 responsiveness in hyperthermic older adults. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2022, 323, R581–R588. [Google Scholar] [CrossRef]
- Coyle-Asbil, B.; Coyle-Asbil, B.; Holjak, E.J.B.; Holjak, E.J.B.; Marrow, J.P.; Marrow, J.P.; Alshamali, R.; Alshamali, R.; Ogilvie, L.M.; Ogilvie, L.M.; et al. Assessing systolic and diastolic reserves in male and female mice. Am. J. Physiol. Heart Circ. Physiol. 2023, 324, H129–H140. [Google Scholar] [CrossRef]
- Tsutsui, J.M.; Falcão, S.N.R.S.; Dourado, P.M.M.; Lima, M.F.; Alves, A.A.; Guerra, V.C.; Ramires, J.A.F.; Mathias, W. Gender differences in chronotropic and hemodynamic responses during dobutamine-atropine stress echocardiography. Echocardiography 2007, 24, 843–850. [Google Scholar] [CrossRef]
- Aquilante, C.L.; Humma, L.M.; Yarandi, H.N.; Andrisin, T.E.; Lewis, J.F.; Hamilton, K.K.; Johnson, J.A. Influence of gender and race on hemodynamic response to dobutamine during dobutamine stress echocardiography. Am. J. Cardiol. 2004, 94, 535–538. [Google Scholar] [CrossRef]
- Hajsadeghi, S.; Rahbar, M.H.; Iranpour, A.; Salehi, A.; Asadi, O.; Jafarian, S.R. Dobutamine-induced takotsubo cardiomyopathy: A systematic review of the literature and case report. Anatol. J. Cardiol. 2018, 19, 412–416. [Google Scholar] [CrossRef]
- Ahtarovski, K.A.; Iversen, K.K.; Lønborg, J.T.; Madsen, P.L.; Engstrøm, T.; Vejlstrup, N.G. Termination of dobutamine infusion causes transient rebound left heart diastolic dysfunction in healthy elderly women but not in men: A cardiac magnetic resonance study. Am. J. Physiol. Heart Circ. Physiol. 2013, 305, H1098–H1103. [Google Scholar] [CrossRef]
Normal Subjects and Desired Response in Septic Shock | Response Frequently Found in Septic Shock | |
---|---|---|
Stroke volume | ↑↑↑ | ↓↔ |
Heart rate | ↑ | ↑↑↑ |
Cardiac output | ↑↑↑ | ↑ |
Blood pressure | ↑↑ | ↓ |
Systemic vascular resistance | ↓ | ↓↓↓ |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Dubin, A.; Mugno, M. The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies. Medicina 2024, 60, 751. https://doi.org/10.3390/medicina60050751
Dubin A, Mugno M. The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies. Medicina. 2024; 60(5):751. https://doi.org/10.3390/medicina60050751
Chicago/Turabian StyleDubin, Arnaldo, and Matías Mugno. 2024. "The Effects of Dobutamine in Septic Shock: An Updated Narrative Review of Clinical and Experimental Studies" Medicina 60, no. 5: 751. https://doi.org/10.3390/medicina60050751