Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade
Abstract
:1. Introduction
2. Natural inhibitors targeting PI3K/PDK1/PKB pathway in insulin-mediated signaling events
2.1. Wortmannin: An inhibitor of PI-3-kinase family members
2.2. Geldanamycin: An inhibitor of Hsp90 and of Hsp90-dependent-signalling components
2.3. Okadaic acid : An inhibitor of serine/threonine protein phosphatase
2.4. Rapamycin: an inhibitor of mTOR-dependent signaling pathways
3. Conclusions
Acknowledgments
References and Notes
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Cho, J.Y.; Park, J. Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade. Int. J. Mol. Sci. 2008, 9, 2217-2230. https://doi.org/10.3390/ijms9112217
Cho JY, Park J. Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade. International Journal of Molecular Sciences. 2008; 9(11):2217-2230. https://doi.org/10.3390/ijms9112217
Chicago/Turabian StyleCho, Jae Youl, and Jongsun Park. 2008. "Contribution of Natural Inhibitors to the Understanding of the PI3K/PDK1/PKB Pathway in the Insulin-mediated Intracellular Signaling Cascade" International Journal of Molecular Sciences 9, no. 11: 2217-2230. https://doi.org/10.3390/ijms9112217