Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Chemical Synthesis
4.2. Evaluation of the Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC)
4.3. Cytotoxicity on Human Skin Normal WS1 Fibroblast Cells
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Compound | L. monocytogenes Scott A | L. monocytogenes Scott A | WS1 |
---|---|---|---|
MIC (MBC) µg/mL a | MIC (µM) a | IC50 (µM) b | |
resveratrol | 200 (-) c | 876 | >200 |
pterostilbene | 64 (128) | 250 | 57 ± 10 |
1 dehydro-δ-viniferin | 2 (16) | 4.42 | 37.0 ± 1.4 |
2 viniferifuran | 16 (>512) | 35.4 | 33.0 ± 1.4 |
3 | 16 (64) | 50.3 | 98.7 ± 1.8 |
4 | 256 (>512) | 743 | 97.8 ± 3.0 |
5 | 16 (64) | 44.4 | 96.8 ± 4.5 |
6 | 64 (>512) | 191 | 98.5 ± 2.0 |
7 | 8 (64) | 23.2 | 45.0 ± 1.2 |
8 | 64 (>512) | 178 | 85.0 ± 4.6 |
9 | >512 (>512) | 1370 | 95.0 ± 2.3 |
10 | >256 (>256) | 662 | >100 |
11 | >256 (>256) | 656 | >100 |
Chlorhexidine | 8 (32) | 15.8 | - |
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Catinella, G.; Mattio, L.M.; Musso, L.; Arioli, S.; Mora, D.; Beretta, G.L.; Zaffaroni, N.; Pinto, A.; Dallavalle, S. Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes. Int. J. Mol. Sci. 2020, 21, 2168. https://doi.org/10.3390/ijms21062168
Catinella G, Mattio LM, Musso L, Arioli S, Mora D, Beretta GL, Zaffaroni N, Pinto A, Dallavalle S. Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes. International Journal of Molecular Sciences. 2020; 21(6):2168. https://doi.org/10.3390/ijms21062168
Chicago/Turabian StyleCatinella, Giorgia, Luce M. Mattio, Loana Musso, Stefania Arioli, Diego Mora, Giovanni Luca Beretta, Nadia Zaffaroni, Andrea Pinto, and Sabrina Dallavalle. 2020. "Structural Requirements of Benzofuran Derivatives Dehydro-δ- and Dehydro-ε-Viniferin for Antimicrobial Activity Against the Foodborne Pathogen Listeria monocytogenes" International Journal of Molecular Sciences 21, no. 6: 2168. https://doi.org/10.3390/ijms21062168