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Volume 2; 2011

Review
Prognostic Factors for Failure after Prostatectomy
Gregory P. Swanson, Joseph W. Basler
J. Cancer 2011; 2: 1-19. doi:10.7150/jca.2.1
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Case Report
Complications of Methylene Blue Dye in Breast Surgery: Case Reports and Review of the Literature
FJ Reyes, MB Noelck, C Valentino, L Grasso-LeBeau, JE Lang
J. Cancer 2011; 2: 20-25. doi:10.7150/jca.2.20
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Review
Targeted therapies in cancer - challenges and chances offered by newly developed techniques for protein analysis in clinical tissues
K Malinowsky, C Wolff, S Gündisch, D Berg, KF Becker
J. Cancer 2011; 2: 26-35. doi:10.7150/jca.2.26
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Research Paper
Effects of an Indolocarbazole-Derived CDK4 Inhibitor on Breast Cancer Cells
Yuan Sun, Ying-xia Li, Hai-jun Wu, Si-hung Wu, Y. Alan Wang, Dian-zhong Luo, D. Joshua Liao
J. Cancer 2011; 2: 36-51. doi:10.7150/jca.2.36
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Research Paper
Smoking and Prognostic Factors in an Observational Setting in Patients with Advanced Non-Small Cell Lung Carcinoma
Chien-Te Li, Magdalena Marek, Salih Z Guclu, Younseup Kim, Mohamed Meshref, Shukui Qin, Zbigniew Kadziola, Kurt Krejcy, Sedat Altug
J. Cancer 2011; 2: 52-61. doi:10.7150/jca.2.52
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Research Paper
Incidence and Impact of Baseline Electrolyte Abnormalities in Patients Admitted with Chemotherapy Induced Febrile Neutropenia
Asim Jamal Shaikh, Samira Ahmed Bawany, Nehal Masood, Ausaf Ahmed Khan, Ahmed Nadeem Abbasi, Syed Najeeb Niamutullah, Adnan Zaidi, Salman Adil, Shiyam Kumar
J. Cancer 2011; 2: 62-66. doi:10.7150/jca.2.62
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Research Paper
miR-21 Expression in Pregnancy-Associated Breast Cancer: A Possible Marker of Poor Prognosis
Beatriz A. Walter, Gabriela Gómez-Macias, Vladimir A. Valera, Mark Sobel, Maria J. Merino
J. Cancer 2011; 2: 67-75. doi:10.7150/jca.2.67
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Research Paper
Patients with Localised Prostate Cancer (T1 - T2) Show Improved Overall Long-Term Survival Compared to the Normal Population
Michael J. Mathers, Stephan Roth, Monika Klinkhammer-Schalke, Michael Gerken, Ferdinand Hofstaedter, Stefan Wilm, Theodor Klotz
J. Cancer 2011; 2: 76-80. doi:10.7150/jca.2.76
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Research Paper
Phase I Dose Escalation Study of Sodium Stibogluconate (SSG), a Protein Tyrosine Phosphatase Inhibitor, Combined with Interferon Alpha for Patients with Solid Tumors
Aung Naing, James M. Reuben, Luis H. Camacho, Hui Gao, Bang-Ning Lee, Evan N. Cohen, Claire Verschraegen, Saneese Stephen, Joann Aaron, David Hong, Jennifer Wheler, Razelle Kurzrock
J. Cancer 2011; 2: 81-89. doi:10.7150/jca.2.81
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Research Paper
Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists
Jeanny H. Wang, Jerzy Lasota, Markku Miettinen
J. Cancer 2011; 2: 90-93. doi:10.7150/jca.2.90
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Research Paper
Pathogenesis of Ovarian Clear Cell Adenofibroma, Atypical Proliferative (Borderline) Tumor, and Carcinoma: Clinicopathologic Features of Tumors with Endometriosis or Adenofibromatous Components Support Two Related Pathways of Tumor Development
Chengquan Zhao, Lee Shu-Fune Wu, Ross Barner
J. Cancer 2011; 2: 94-106. doi:10.7150/jca.2.94
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Review
Human Cancer Classification: A Systems Biology- Based Model Integrating Morphology, Cancer Stem Cells, Proteomics, and Genomics
Halliday A Idikio
J. Cancer 2011; 2: 107-115. doi:10.7150/jca.2.107
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Review
miRNA Biomarkers in Breast Cancer Detection and Management
Sidney W. Fu, Liang Chen, Yan-gao Man
J. Cancer 2011; 2: 116-122. doi:10.7150/jca.2.116
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Research Paper
In Vivo Imaging of Human Malignant Mesothelioma Grown Orthotopically in the Peritoneal Cavity of Nude Mice
Mingqian Feng, Jingli Zhang, Miriam Anver, Raffit Hassan, Mitchell Ho
J. Cancer 2011; 2: 123-131. doi:10.7150/jca.2.123
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Case Report
Adult Wilms Tumor with Intracaval and Intracardiac Extension: Report of a Case and Review of Literature
Aitao Guo, Lixin Wei, Xin Song, Aijun Liu
J. Cancer 2011; 2: 132-135. doi:10.7150/jca.2.132
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Research Paper
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer
Binxue Zhang, Mina Izadjoo, Iren Horkayne-Szakaly, Alan Morrison, Douglas J. Wear
J. Cancer 2011; 2: 136-141. doi:10.7150/jca.2.136
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Research Paper
An Effective Personalized Approach to a Rare Tumor: Prolonged Survival in Metastatic Pancreatic Acinar Cell Carcinoma Based on Genetic Analysis and Cell Line Development
Matthew D. Armstrong, Daniel Von Hoff, Bruce Barber, Laura A. Marlow, Christina von Roemeling, Simon J. Cooper, Patrick Travis, Elizabeth Campbell, Ricardo Paz-Fumagalli, John A. Copland, Gerardo Colon-Otero
J. Cancer 2011; 2: 142-152. doi:10.7150/jca.2.142
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Research Paper
A Retrospective Review of the Frequency and Nature of Acute Hypersensitivity Reactions at a Medium-Sized Infusion Center: Comparison to Reported Values and Inconsistencies Found in Literature
Patricia A. DeMoor, Yuri Matusov, Colleen Kelly, Shobha Kolan, Linda Barnachea, Lyudmila A. Bazhenova
J. Cancer 2011; 2: 153-164. doi:10.7150/jca.2.153
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Research Paper
Protein Signatures in Human MDA-MB-231 Breast Cancer Cells Indicating a More Invasive Phenotype Following Knockdown of Human Endometase/Matrilysin-2 by siRNA
Seakwoo Lee, Doris Terry, Douglas R. Hurst, Danny R. Welch, Qing-Xiang Amy Sang
J. Cancer 2011; 2: 165-176. doi:10.7150/jca.2.165
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Research Paper
Mature Results of a Prospective Randomized Trial Comparing 5-Flourouracil with Leucovorin to 5-Flourouracil with Levamisole as Adjuvant Therapy of Stage II and III Colorectal Cancer- The Israel Cooperative Oncology Group (ICOG) Study
Arie Figer, Aviram Nissan, Adi Shani, Riva Borovick, Mariana Stiener, Mario Baras, Herbert R. Freund, Aaron Sulkes, Alexander Stojadinovic, Tamar Peretz
J. Cancer 2011; 2: 177-185. doi:10.7150/jca.2.177
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Case Study
Infiltrating Ductal Carcinoma of the Breast Associated with Primary Breast Lymphoma
Myron Arlen, Jacob J. Freiman, Marina Ionescu
J. Cancer 2011; 2: 186-192. doi:10.7150/jca.2.186
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Review
Thyroid Cancer: Burden of Illness and Management of Disease
Rebecca L. Brown, Jonas A. de Souza, Ezra EW Cohen
J. Cancer 2011; 2: 193-199. doi:10.7150/jca.2.193
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Research Paper
Medullary Thyroid Cancer: It is a pain in the neck?
Marlon A. Guerrero, Sheila Lindsay, Insoo Suh, Menno R. Vriens, Elham Khanafshar, Wen T. Shen, Jessica Gosnell, Electron Kebebew, Quan-Yang Duh, Orlo H. Clark
J. Cancer 2011; 2: 200-205. doi:10.7150/jca.2.200
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Case Report
Primary Solitary Fibrous Tumor of the Thyroid - Report of a Case and Review of the Literature
Zhigang Song, Chunkai Yu, Xin Song, Lixin Wei, Aijun Liu
J. Cancer 2011; 2: 206-209. doi:10.7150/jca.2.206
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Review
Consensus Recommendations for Advancing Breast Cancer: Risk Identification and Screening in Ethnically Diverse Younger Women
Alexander Stojadinovic, Thomas A Summers, John Eberhardt, Albert Cerussi, Warren Grundfest, Charles M. Peterson, Michael Brazaitis, Elizabeth Krupinski, Harold Freeman
J. Cancer 2011; 2: 210-227. doi:10.7150/jca.2.210
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Case Report
Unusual Ovarian Stromal Tumor with Radiation Changes Mimicking Carcinoma
Olga L. Bohn, Chengquan Zhao, Mirka W. Jones
J. Cancer 2011; 2: 228-231. doi:10.7150/jca.2.228
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Review
Biological Markers in DCIS and Risk of Breast Recurrence: A Systematic Review
Sara A. Lari, Henry M. Kuerer
J. Cancer 2011; 2: 232-261. doi:10.7150/jca.2.232
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Research Paper
Cellular and Phenotypic Characterization of Canine Osteosarcoma Cell Lines
Marie E. Legare, Jamie Bush, Amanda K. Ashley, Taka Kato, William H. Hanneman
J. Cancer 2011; 2: 262-270. doi:10.7150/jca.2.262
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Research Paper
Differential Genetic Expression in Large Versus Small Clear Cell Renal Cell Carcinoma: Results from Microarray Analysis
Gennady Bratslavsky, Thomas Sanford, Ramaprasad Srinivasan, Olga Aprelikova, Jack Liu, Martha Quezado, Maria Merino, W. Marston Linehan
J. Cancer 2011; 2: 271-279. doi:10.7150/jca.2.271
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Research Paper
HN125: A Novel Immunoadhesin Targeting MUC16 with Potential for Cancer Therapy
Xinran Xiang, Mingqian Feng, Mildred Felder, Joseph P. Connor, Yan-gao Man, Manish S. Patankar, Mitchell Ho
J. Cancer 2011; 2: 280-291. doi:10.7150/jca.2.280
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Review
Disruption of Learning Processes by Chemotherapeutic Agents in Childhood Survivors of Acute Lymphoblastic Leukemia and Preclinical Models
Emily B. Bisen-Hersh, Philip N. Hineline, Ellen A. Walker
J. Cancer 2011; 2: 292-301. doi:10.7150/jca.2.292
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Case Report
Primary Mucinous Adenocarcinoma of the Vermiform Appendix with High Grade Microsatellite Instability
Moritz Komm, Michaela Kronawitter-Fesl, Marcus Kremer, Ludwig Lutz, Elke Holinski-Feder, Reinhard Kopp
J. Cancer 2011; 2: 302-306. doi:10.7150/jca.2.302
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Editorial
4th Edition of the International Autologous and Allogeneic Cell Therapy for Solid Tumors (ATST) Meeting
Marco Bregni, Richard W. Childs, Naoto T. Ueno
J. Cancer 2011; 2: 307-308. doi:10.7150/jca.2.307
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Review
Novel Monoclonal Antibodies for Cancer Treatment: The Trifunctional Antibody Catumaxomab (Removab^®)
Diane Seimetz
J. Cancer 2011; 2: 309-316. doi:10.7150/jca.2.309
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Review
Immune Effects of Trastuzumab
Marianna Nuti, Filippo Bellati, Valeria Visconti, Chiara Napoletano, Lavinia Domenici, Jlenia Caccetta, Ilaria Grazia Zizzari, Ilary Ruscito, Hassan Rahimi, Pierluigi Benedetti-Panici, Aurelia Rughetti
J. Cancer 2011; 2: 317-323. doi:10.7150/jca.2.317
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Short Report
Targeting EGFR in Triple Negative Breast Cancer
Naoto T. Ueno, Dongwei Zhang
J. Cancer 2011; 2: 324-328. doi:10.7150/jca.2.324
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Short Report
A Clinical Study of a Cell-Based MAGE-A3 Active Immunotherapy in Advanced Melanoma Patients
Vincenzo Russo, Francesca Lunghi, Raffaella Fontana, Marco Bregni
J. Cancer 2011; 2: 329-330. doi:10.7150/jca.2.329
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Short Report
Chimeric Antigen Receptor Therapy for B-cell Malignancies
David L Porter, Michael Kalos, Zhaohui Zheng, Bruce Levine, Carl June
J. Cancer 2011; 2: 331-332. doi:10.7150/jca.2.331
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Review
Immunological Effects of Multikinase Inhibitors for Kidney Cancer: A Clue for Integration with Cellular Therapies?
Camillo Porta, Chiara Paglino, Ilaria Imarisio, Carlo Ganini, Paolo Pedrazzoli
J. Cancer 2011; 2: 333-338. doi:10.7150/jca.2.333
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Short Report
Innovative Platforms for Haploidentical Stem Cell Transplantation: The Role of Unmanipulated Donor Graft
Fabio Ciceri, Marco Bregni, Jacopo Peccatori
J. Cancer 2011; 2: 339-340. doi:10.7150/jca.2.339
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Short Report
T Cell Therapy for Nasopharyngeal Carcinoma
S Basso, M Zecca, P Merli, A Gurrado, S Secondino, G Quartuccio, I Guido, P Guerini, G Ottonello, N Zavras, R Maccario, P Pedrazzoli, P Comoli
J. Cancer 2011; 2: 341-346. doi:10.7150/jca.2.341
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Short Report
Allogeneic Stem Cell Transplantation for Metastatic Renal Cell Cancer (RCC)
Marco Bregni, Fabio Ciceri, Jacopo Peccatori
J. Cancer 2011; 2: 347-349. doi:10.7150/jca.2.347
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Review
Immunotherapeutic Intervention against Sarcomas
Paolo Pedrazzoli, Simona Secondino, Vittorio Perfetti, Patrizia Comoli, Daniela Montagna
J. Cancer 2011; 2: 350-356. doi:10.7150/jca.2.350
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Short Report
Sipuleucel-T: Autologous Cellular Immunotherapy for Men with Asymptomatic or Minimally Symptomatic Metastatic Castrate Resistant Prostate Cancer
Robert B. Sims
J. Cancer 2011; 2: 357-359. doi:10.7150/jca.2.357
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Short Report
Adoptive Cell Therapy for Patients with Melanoma
Mark E. Dudley
J. Cancer 2011; 2: 360-362. doi:10.7150/jca.2.360
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Short Report
Cytokine Induced Killer Cells as Promising Immunotherapy for Solid Tumors
Dario Sangiolo
J. Cancer 2011; 2: 363-368. doi:10.7150/jca.2.363
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Review
Biology of Metastatic Renal Cell Carcinoma
Michele Milella, Alessandra Felici
J. Cancer 2011; 2: 369-373. doi:10.7150/jca.2.369
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Review
Is High Dose Therapy Superior to Conventional Dose Therapy as Initial Treatment for Relapsed Germ Cell Tumors? The TIGER Trial
Darren R. Feldman, Robert Huddart, Emma Hall, Jörg Beyer, Thomas Powles
J. Cancer 2011; 2: 374-377. doi:10.7150/jca.2.374
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Mini-Review
Suicide Gene Therapy to Increase the Safety of Chimeric Antigen Receptor-Redirected T Lymphocytes
Monica Casucci, Attilio Bondanza
J. Cancer 2011; 2: 378-382. doi:10.7150/jca.2.378
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Short Report
Bortezomib Treatment to Potentiate the Anti-tumor Immunity of Ex-vivo Expanded Adoptively Infused Autologous Natural Killer Cells
Andreas Lundqvist, Maria Berg, Aleah Smith, Richard W. Childs
J. Cancer 2011; 2: 383-385. doi:10.7150/jca.2.383
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Research Paper
Complex Alternative Splicing of the Smarca2 Gene Suggests the Importance of Smarca2-B Variants
Min Yang, Yuan Sun, Ling Ma, Chenguang Wang, Jian-min Wu, Anding Bi, D. Joshua Liao
J. Cancer 2011; 2: 386-400. doi:10.7150/jca.2.386
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Research Paper
In Situ Malignant Transformation and Progenitor-Mediated Cell Budding: Two Different Pathways for Breast Ductal and Lobular Tumor Invasion
Yan-gao Man, Mina Izadjoo, Guohong Song, Alexander Stojadinovic
J. Cancer 2011; 2: 401-412. doi:10.7150/jca.2.401
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Commentary
Malignant Transformation and Stromal Invasion from Normal or Hyperplastic Tissues: True or False?
Yan-gao Man, Michael Grinkemeyer, Mina Izadjoo, Alexander Stojadinovic
J. Cancer 2011; 2: 413-424. doi:10.7150/jca.2.413
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Research Paper
A Meta-Analysis of the Short- and Long-Term Results of Randomized Controlled Trials That Compared Laparoscopy-Assisted and Conventional Open Surgery for Colorectal Cancer
Hiroshi Ohtani, Yutaka Tamamori, Yuichi Arimoto, Yukio Nishiguchi, Kiyoshi Maeda, Kosei Hirakawa
J. Cancer 2011; 2: 425-434. doi:10.7150/jca.2.425
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Research Paper
Gemcitabine Overcomes Erlotinib Resistance in EGFR-Overexpressing Cancer Cells through Downregulation of Akt
Chandra Bartholomeusz, Fumiyuki Yamasaki, Hitomi Saso, Kaoru Kurisu, Gabriel N. Hortobagyi, Naoto T. Ueno
J. Cancer 2011; 2: 435-442. doi:10.7150/jca.2.435
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Review
Tumor Induced Inactivation of Natural Killer Cell Cytotoxic Function; Implication in Growth, Expansion and Differentiation of Cancer Stem Cells
Anahid Jewett, Han-Ching Tseng
J. Cancer 2011; 2: 443-457. doi:10.7150/jca.2.443
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Research Paper
Optimizing a 3D Culture System to Study the Interaction between Epithelial Breast Cancer and Its Surrounding Fibroblasts
Liyuan Li, Yi Lu
J. Cancer 2011; 2: 458-466. doi:10.7150/jca.2.458
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Research Paper
Impact of Patient Navigation from Diagnosis to Treatment in an Urban Safety Net Breast Cancer Population
Nisreen A Haideri, Jill A Moormeier
J. Cancer 2011; 2: 467-473. doi:10.7150/jca.2.467
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Case Report
Synchronous Lung Cancers: When Same Histological Types Feature Different Molecular Profiles and Response Phenotypes
Giulia M Stella, Francesca Cemmi, Simona Inghilleri, Michele Zorzetto, Maurizio Luisetti, Ernesto Pozzi
J. Cancer 2011; 2: 474-477. doi:10.7150/jca.2.474
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Short Research Communication
The First Type III Domain of Fibronectin is Associated with the Expression of Cytokines within the Lung Tumor Microenvironment
Mingzhe Zheng, David M. Jones, Carol Horzempa, Aparna Prasad, Paula J. McKeown-Longo
J. Cancer 2011; 2: 478-483. doi:10.7150/jca.2.478
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Case Report
Metastatic Signet Ring Cell Carcinoma of the Bilateral Breasts and Ovaries from Gastrointestinal Tract in a Young Breastfeeding Female - A Case Report
QingPing Jiang, Shaoyan Liu, Hanzhen Xiong, Juan Pen, Kuan Cai, YueXin Yang, ZhongTang Xiong
J. Cancer 2011; 2: 484-489. doi:10.7150/jca.2.484
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Research Paper
miRNA Alterations Modify Kinase Activation In The IGF-1 Pathway And Correlate With Colorectal Cancer Stage And Progression In Patients
David L. Knowlton, Kim Tang, Peter V. Henstock, Romesh R. Subramanian
J. Cancer 2011; 2: 490-502. doi:10.7150/jca.2.490
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Case Report
Cavitary Lung Cancer Lined with Normal Bronchial Epithelium and Cancer Cells
Taichiro Goto, Arafumi Maeshima, Yoshitaka Oyamada, Ryoichi Kato
J. Cancer 2011; 2: 503-506. doi:10.7150/jca.2.503
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Technical Report
Rapid Generation of In Vitro Multicellular Spheroids for the Study of Monoclonal Antibody Therapy
Yen T. Phung, Dario Barbone, V. Courtney Broaddus, Mitchell Ho
J. Cancer 2011; 2: 507-514. doi:10.7150/jca.2.507
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Research Paper
Regulatory Effects of microRNA-92 (miR-92) on VHL Gene Expression and the Hypoxic Activation of miR-210 in Clear Cell Renal Cell Carcinoma
Vladimir A. Valera, Beatriz A. Walter, W. Marston Linehan, Maria J. Merino
J. Cancer 2011; 2: 515-526. doi:10.7150/jca.2.515
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Case Report
Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine
Anselm Chi-wai Lee, Peter Yu-tang Goh
J. Cancer 2011; 2: 527-531. doi:10.7150/jca.2.527
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Review
Parathyroid Carcinoma: A Review with Three Illustrative Cases
Antoine Digonnet, Adelaïde Carlier, Esther Willemse, Marie Quiriny, Cécile Dekeyser, Nicolas de Saint Aubain, Marc Lemort, Guy Andry
J. Cancer 2011; 2: 532-537. doi:10.7150/jca.2.532
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Research Paper
Malignant Melanoma in the Elderly: Different Regional Disease and Poorer Prognosis
James B. Macdonald, Amylou C. Dueck, Richard J. Gray, Nabil Wasif, David L. Swanson, Aleksandar Sekulic, Barbara A. Pockaj
J. Cancer 2011; 2: 538-543. doi:10.7150/jca.2.538
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