POLD1
Изглед
Katalitička podjedinica DNK polimeraze delta je enzim koji je kod ljudi kodiran POLD1 genom.[4][5] Ona je komponenta kompleksa DNK polimeraza delta.
POLD1, zajedno sa enzimom POLE, je asocirana sa višestrukim adenomom.[6]
Reference
[уреди | уреди извор]- ^ а б в GRCm38: Ensembl release 89: ENSMUSG00000038644 - Ensembl, May 2017
- ^ „Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ „Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Chung DW, Zhang JA, Tan CK, Davie EW, So AG, Downey KM (1992). „Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene”. Proc Natl Acad Sci U S A. 88 (24): 11197—201. PMC 53101
. PMID 1722322. doi:10.1073/pnas.88.24.11197.
- ^ „Entrez Gene: POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa”.
- ^ Palles C, Cazier JB et al. Nature Genetics 2013. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Literatura
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- Shevelev IV, Ramadan K, Hübscher U (2004). „The TREX2 3'-->5' exonuclease physically interacts with DNA polymerase delta and increases its accuracy.”. ScientificWorldJournal. 2: 275—81. PMID 12806015. doi:10.1100/tsw.2002.99.