GSK-789,472

GSK-789,472
IUPAC ime
	4,5-dihidro-1-fenil-3-(piperidin-2-il)metilimidazol-2(1H)on
Identifikatori
ATC kod	none
Hemijski podaci
Formula	C15H21N3O
Molarna masa	259,168 g/mol
	SMILES O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3; ;

GSK-789,472 je lek koji deluje kao potentan i selektivan parcijalni agonist na dopaminskom receptoru D₂, kao i antagonist na srodnom D₃ podtipu. On ima dobru selektivnost u odnosu na D₄ i druge receptore.^[1]

Reference

^ Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (2010). „The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure”. Bioorganic & Medicinal Chemistry Letters. 20 (6): 2013—6. PMID 20153647. doi:10.1016/j.bmcl.2010.01.090.

Spoljašnje veze

[pmid20153647-1] Holmes IP, Blunt RJ, Lorthioir OE, Blowers SM, Gribble A, Payne AH, Stansfield IG, Wood M, Woollard PM, Reavill C, Howes CM, Micheli F, Di Fabio R, Donati D, Terreni S, Hamprecht D, Arista L, Worby A, Watson SP (2010). „The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure”. Bioorganic & Medicinal Chemistry Letters. 20 (6): 2013—6. PMID 20153647. doi:10.1016/j.bmcl.2010.01.090.

[1]