BRL-52537
 | |
| IUPAC ime | |
|---|---|
2-(3,4-diclorofenil)-1-[(2S)-2-(pirolidin-1-ilmetil)piperidin-1-il]etanon | |
| Identifikatori | |
| CAS broj | 130497-33-5  |
| ATC kod | none |
| PubChem | CID 6603740 |
| Hemijski podaci | |
| Formula | C18H24Cl2N2O |
| Molarna masa | 355.301 g/mol |
| |
BRL-52537 je lek koji deluje kao potentan i visoko selektivan κ-opioidni agonist.[1] On je pokazao neuroprotektivno dejstvo u studijama na životinjama,[2][3] i koristi se za istraživanje potencijalnih tretmana za moždani i srčani udar, kao i za neka uopštenija istraživanja mozga.[4][5][6]
Reference
[уреди | уреди извор]- ^ Vecchietti V, Giordani A, Giardina G, Colle R, Clarke GD (1991). „(2S)-1-(arylacetyl)-2-(aminomethyl)piperidine derivatives: novel, highly selective kappa opioid analgesics”. Journal of Medicinal Chemistry. 34 (1): 397—403. PMID 1846921.
- ^ Goyagi T, Toung TJ, Kirsch JR, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (2003). „Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats”. Stroke; a Journal of Cerebral Circulation. 34 (6): 1533—8. PMID 12738895. doi:10.1161/01.STR.0000072512.30658.E7.
- ^ Zhang Z, Chen TY, Kirsch JR, Toung TJ, Traystman RJ, Koehler RC, Hurn PD, Bhardwaj A (2003). „Kappa-opioid receptor selectivity for ischemic neuroprotection with BRL 52537 in rats”. Anesthesia and Analgesia. 97 (6): 1776—83. PMID 14633559.
- ^ Chen TY, Goyagi T, Toung TJ, Kirsch JR, Hurn PD, Koehler RC, Bhardwaj A (2004). „Prolonged opportunity for ischemic neuroprotection with selective kappa-opioid receptor agonist in rats”. Stroke; a Journal of Cerebral Circulation. 35 (5): 1180—5. PMID 15031456. doi:10.1161/01.STR.0000125011.93188.c6.
- ^ Peart JN, Gross ER, Gross GJ (2004). „Effect of exogenous kappa-opioid receptor activation in rat model of myocardial infarction”. Journal of Cardiovascular Pharmacology. 43 (3): 410—5. PMID 15076225.
- ^ Britt JP, McGehee DS (2008). „Presynaptic opioid and nicotinic receptor modulation of dopamine overflow in the nucleus accumbens”. The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 28 (7): 1672—81. PMID 18272687. doi:10.1523/JNEUROSCI.4275-07.2008.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
