Rolofilin
 | |
| IUPAC ime | |
|---|---|
8-(Heksahidro-2,5-metanopentalen-3a(1H)-il)-3,7-dihidro-1,3-dipropil-1H-purin-2,6-dion | |
| Pravni status | |
| Pravni status |
|
| Identifikatori | |
| CAS broj | 136199-02-5  |
| ATC kod | C03BD (WHO) |
| PubChem | CID 64627 |
| ChemSpider | 58188 |
| UNII | 7805S5HIHX |
| Hemijski podaci | |
| Formula | C20H28N4O2 |
| Molarna masa | 356,46 g/mol |
Rolofilin (KW-3902) je eksperimentalni diuretik koji deluje kao selektivni antagonist adenozinskog A1 receptora.[1][2]
Reference
[uredi | uredi izvor]- ^ Givertz MM, Massie BM, Fields TK, Pearson LL, Dittrich HC (2007). „The effects of KW-3902, an adenosine A1-receptor antagonist,on diuresis and renal function in patients with acute decompensated heart failure and renal impairment or diuretic resistance”. J. Am. Coll. Cardiol. 50 (16): 1551—60. PMID 17936154. doi:10.1016/j.jacc.2007.07.019.
- ^ Cotter G, Dittrich HC, Weatherley BD, Bloomfield DM, O'Connor CM, Metra M, Massie BM (2008). „The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment”. Journal of Cardiac Failure. 14 (8): 631—40. PMID 18926433. doi:10.1016/j.cardfail.2008.08.010.
