Receptor insulinu sličnog faktora rasta 2

Receptor insulinu sličnog faktora rasta 2‎
	; PDB prikaz baziran na 1e6f.
Dostupne strukture
	1E6F, 1GP0, 1GP3, 1GQB, 1JWG, 1LF8, 2CNJ, 2L29, 2L2A, 2V5N, 2V5O, 2V5P
Identifikatori
Simboli	IGF2R; CD222; CIMPR; M6P-R; MPR1; MPRI
Vanjski ID	OMIM: 147280 MGI: 96435 HomoloGene: 676 GeneCards: IGF2R Gene
Ontologija gena
Molekularna funkcija	• glikoproteinsko vezivanje; • receptorksa aktivnost; • aktivnost aktiviranog receptora insulinu sličnog faktora rasta;
Celularna komponenta	• lizozomalna membrana; • endozom; • integralno sa ćelijskom membranom;
Biološki proces	• receptorom posredovana endocitoza; • prenos signala; • signalni put receptora insulinu sličnog faktora rasta;
Pregled RNK izražavanja
	podaci
Ortolozi

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Receptor insulinu sličnog faktora rasta 2 (IGF2R, katjionski nezavisni receptor manoza-6-fosfata, CI-MPR) je protein koji je kod ljudi kodiran IGF2R genom.^[1]^[2] IGF2R je multifunkcionalni proteinski receptor za koji se vezuje insulinu sličan faktor rasta 2 (IGF2) na ćelijskoj površini i manoza-6-fosfat (M6P)-obeležene proteine u trans-Goldžijevom apararu.^[2]

Interakcije

Receptor insulinu sličnog faktora rasta 2 formira interakcije sa M6PRBP1.^[3]^[4]

Reference

↑ Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
↑ ^2,0 ^2,1 Laureys G, Barton DE, Ullrich A, Francke U (October 1988). „Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse”. Genomics 3 (3): 224–9. DOI:10.1016/0888-7543(88)90083-3. PMID 2852162.
↑ Díaz E, Pfeffer SR (May 1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.
↑ Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). „Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. DOI:10.1073/pnas.160251397. PMC 16819. PMID 10908666.

Literatura

O'Dell SD, Day IN (1998). „Insulin-like growth factor II (IGF-II)”. Int. J. Biochem. Cell Biol. 30 (7): 767–71. DOI:10.1016/S1357-2725(98)00048-X. PMID 9722981.
Hawkes C, Kar S (2004). „The insulin-like growth factor-II/mannose-6-phosphate receptor: structure, distribution and function in the central nervous system”. Brain Res. Brain Res. Rev. 44 (2–3): 117–40. DOI:10.1016/j.brainresrev.2003.11.002. PMID 15003389.
Scott CD, Firth SM (2005). „The role of the M6P/IGF-II receptor in cancer: tumor suppression or garbage disposal?”. Horm. Metab. Res. 36 (5): 261–71. DOI:10.1055/s-2004-814477. PMID 15156403.
Antoniades HN, Galanopoulos T, Neville-Golden J, Maxwell M (1992). „Expression of insulin-like growth factors I and II and their receptor mRNAs in primary human astrocytomas and meningiomas; in vivo studies using in situ hybridization and immunocytochemistry”. Int. J. Cancer 50 (2): 215–22. DOI:10.1002/ijc.2910500210. PMID 1370435.
Zhou J, Bondy C (1992). „Insulin-like growth factor-II and its binding proteins in placental development”. Endocrinology 131 (3): 1230–40. DOI:10.1210/en.131.3.1230. PMID 1380437.
Morgan DO, Edman JC, Standring DN, et al. (1987). „Insulin-like growth factor II receptor as a multifunctional binding protein”. Nature 329 (6137): 301–7. DOI:10.1038/329301a0. PMID 2957598.
Oshima A, Nolan CM, Kyle JW, et al. (1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.
De Souza AT, Hankins GR, Washington MK, et al. (1996). „M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity”. Nat. Genet. 11 (4): 447–9. DOI:10.1038/ng1295-447. PMID 7493029.
Ilvesmäki V, Blum WF, Voutilainen R (1994). „Insulin-like growth factor binding proteins in the human adrenal gland”. Mol. Cell. Endocrinol. 97 (1–2): 71–9. DOI:10.1016/0303-7207(93)90212-3. PMID 7511544.
De Souza AT, Hankins GR, Washington MK, et al. (1995). „Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors”. Oncogene 10 (9): 1725–9. PMID 7753549.
Schmidt B, Kiecke-Siemsen C, Waheed A, et al. (1995). „Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor”. J. Biol. Chem. 270 (25): 14975–82. DOI:10.1074/jbc.270.25.14975. PMID 7797478.
Rao PH, Murty VV, Gaidano G, et al. (1994). „Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization”. Cytogenet. Cell Genet. 66 (4): 272–3. DOI:10.1159/000133710. PMID 8162705.
Ishiwata T, Bergmann U, Kornmann M, et al. (1997). „Altered expression of insulin-like growth factor II receptor in human pancreatic cancer”. Pancreas 15 (4): 367–73. DOI:10.1097/00006676-199711000-00006. PMID 9361090.
Tikkanen R, Peltola M, Oinonen C, et al. (1998). „Several cooperating binding sites mediate the interaction of a lysosomal enzyme with phosphotransferase”. EMBO J. 16 (22): 6684–93. DOI:10.1093/emboj/16.22.6684. PMC 1170273. PMID 9362483.
Nykjaer A, Christensen EI, Vorum H, et al. (1998). „Mannose 6-Phosphate/Insulin-like Growth Factor–II Receptor Targets the Urokinase Receptor to Lysosomes via a Novel Binding Interaction”. J. Cell Biol. 141 (3): 815–28. DOI:10.1083/jcb.141.3.815. PMC 2132758. PMID 9566979.
Díaz E, Pfeffer SR (1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.
Wan L, Molloy SS, Thomas L, et al. (1998). „PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization”. Cell 94 (2): 205–16. DOI:10.1016/S0092-8674(00)81420-8. PMID 9695949.
Killian JK, Jirtle RL (1999). „Genomic structure of the human M6P/IGF2 receptor”. Mamm. Genome 10 (1): 74–7. DOI:10.1007/s003359900947. PMID 9892739.
Kumar S, Hand AT, Connor JR, et al. (1999). „Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions”. J. Biol. Chem. 274 (24): 17123–31. DOI:10.1074/jbc.274.24.17123. PMID 10358067.

Povezano

Spoljašnje veze

MeSH Insulin-Like-Growth-Factor+II+Receptor

[pmid2963003-1] Oshima A, Nolan CM, Kyle JW, Grubb JH, Sly WS (February 1988). „The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells”. J. Biol. Chem. 263 (5): 2553–62. PMID 2963003.

[pmid2852162-2] 2,0 ^2,1 Laureys G, Barton DE, Ullrich A, Francke U (October 1988). „Chromosomal mapping of the gene for the type II insulin-like growth factor receptor/cation-independent mannose 6-phosphate receptor in man and mouse”. Genomics 3 (3): 224–9. DOI:10.1016/0888-7543(88)90083-3. PMID 2852162.

[pmid9590177-3] Díaz E, Pfeffer SR (May 1998). „TIP47: a cargo selection device for mannose 6-phosphate receptor trafficking”. Cell 93 (3): 433–43. DOI:10.1016/S0092-8674(00)81171-X. PMID 9590177.

[pmid10908666-4] Orsel JG, Sincock PM, Krise JP, Pfeffer SR (August 2000). „Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9047–51. DOI:10.1073/pnas.160251397. PMC 16819. PMID 10908666.

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p r u Proteini: klasteri diferencijacije (vidi isto spisak ljudskih klastera diferencijacije)
1-50	CD1 (a-c, 1A, 1D, 1E) • CD2 • CD3 (γ, δ, ε) • CD4 • CD5 • CD6 • CD7 • CD8 (a) • CD9 • CD10 • CD11 (a, b, c) • CD13 • CD14 • CD15 • CD16 (A, B) • CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • CD35 • CD36 • CD37 • CD38 • CD39 • CD40 • CD41 • CD42 (a, b, c, d) • CD43 • CD44 • CD45 • CD46 • CD47 • CD48 • CD49 (a, b, c, d, e, f) • CD50
51-100	CD51 • CD52 • CD53 • CD54 • CD55 • CD56 • CD57 • CD58 • CD59 • CD61 • CD62 (E, L, P) • CD63 • CD64 (A, B, C) • CD66 (a, b, c, d, e, f) • CD68 • CD69 • CD70 • CD71 • CD72 • CD73 • CD74 • CD78 • CD79 (a, b) • CD80 • CD81 • CD82 • CD83 • CD84 • CD85 (a, d, e, h, j, k) • CD86 • CD87 • CD88 • CD89 • CD90 • CD91- CD92 • CD93 • CD94 • CD95 • CD96 • CD97 • CD98 • CD99 • CD100
101-150	CD101 • CD102 • CD103 • CD104 • CD105 • CD106 • CD107 (a, b) • CD108 • CD109 • CD110 • CD111 • CD112 • CD113 • CD114 • CD115 • CD116 • CD117 • CD118 • CD119 • CD120 (a, b) • CD121 (a, b) • CD122 • CD123 • CD124 • CD125 • CD126 • CD127 • CD129 • CD130 • CD131 • CD132 • CD133 • CD134 • CD135 • CD136 • CD137 • CD138 • CD140b • CD141 • CD142 • CD143 • CD144 • CD146 • CD147 • CD148 • CD150
151-200	CD151 • CD152 • CD153 • CD154 • CD155 • CD156 (a, b, c) • CD157 • CD158 (a, d, e, i, k) • CD159 (a, c) • CD160 • CD161 • CD162 • CD163 • CD164 • CD166 • CD167 (a, b) • CD168 • CD169 • CD170 • CD171 • CD172 (a, b, g) • CD174 • CD177 • CD178 • CD179 (a, b) • CD181 • CD182 • CD183 • CD184 • CD185 • CD186 • CD191 • CD192 • CD193 • CD194 • CD195 • CD196 • CD197 • CDw198 • CDw199 • CD200
201-250	CD201 • CD202b • CD204 • CD205 • CD206 • CD207 • CD208 • CD209 • CDw210 (a, b) • CD212 • CD213a (1, 2) • CD217 • CD218 (a, b) • CD220 • CD221 • CD222 • CD223 • CD224 • CD225 • CD226 • CD227 • CD228 • CD229 • CD230 • CD233 • CD234 • CD235 (a, b) • CD236 • CD238 • CD239 • CD240CE • CD241 • CD243 • CD244 • CD246 • CD247- CD248 • CD249
251-300	CD252 • CD253 • CD254 • CD256 • CD257 • CD258 • CD261 • CD262 • CD264 • CD265 • CD266 • CD267 • CD268 • CD269 • CD271 • CD272 • CD273 • CD274 • CD275 • CD276 • CD278 • CD279 • CD280 • CD281 • CD282 • CD283 • CD284 • CD286 • CD288 • CD289 • CD290 • CD292 • CDw293 • CD294 • CD295 • CD297 • CD298 • CD299
301-350	CD300A • CD301 • CD302 • CD303 • CD304 • CD305 • CD306 • CD307 • CD309 • CD312 • CD314 • CD315 • CD316 • CD317 • CD318 • CD320 • CD321 • CD322 • CD324 • CD325 • CD326 • CD328 • CD329 • CD331 • CD332 • CD333 • CD334 • CD335 • CD336 • CD337 • CD338 • CD339 • CD340 • CD344 • CD349 • CD350

p r u Receptori: Receptori faktora rasta
Nervni faktori rasta	niski afinitet/p75 - visok afinitet Trk (TrkA, TrkB, TrkC) - Cilijarni neurotrofni faktor
Somatomedin	Insulinu-sličan faktor rasta 1 - Insulinu-sličan faktor rasta 2
CSF	Stem ćelijski faktor - Eritropoietin
TGF put	TGF-beta (1, 2) - Aktivin (1, 2) - Bone morfogenetski protein (1, 2)
Drugi	Hepatocitni faktor rasta - ErbB/Epidermalni faktor rasta - Fibroblast faktor rasta (1, 2, 3, 4) - Trombocit-izvedeni faktor rasta (A, B) - VEGF (1, 2, 3)
vidi isto Faktori rasta
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)