(Q92616532)

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30 April 2020

title

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design (English)

1 reference

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Publisher Correction: BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

30 April 2020

corrigendum / erratum

0 references

author

William Farnaby

1

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30 April 2020

Michael J Roy

3

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30 April 2020

Claire Whitworth

4

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30 April 2020

Emelyne Diers

5

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30 April 2020

Christian Dank

13

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Katharina Ehrenhöfer-Wölfer

30 April 2020

26

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30 April 2020

Simon Wöhrle

27

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30 April 2020

Peter Ettmayer

34

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30 April 2020

Darryl B McConnell

36

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30 April 2020

Alessio Ciulli

37

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30 April 2020

author name string

Manfred Koegl

2

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30 April 2020

Nicole Trainor

6

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30 April 2020

David Zollman

7

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30 April 2020

Steffen Steurer

8

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30 April 2020

Jale Karolyi-Oezguer

9

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30 April 2020

Carina Riedmueller

10

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30 April 2020

Teresa Gmaschitz

11

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30 April 2020

Johannes Wachter

12

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30 April 2020

Michael Galant

14

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Bernadette Sharps

15

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30 April 2020

Klaus Rumpel

16

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Elisabeth Traxler

17

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30 April 2020

Thomas Gerstberger

18

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30 April 2020

Renate Schnitzer

19

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30 April 2020

Oliver Petermann

20

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30 April 2020

Peter Greb

21

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30 April 2020

Harald Weinstabl

22

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Gerd Bader

23

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30 April 2020

Andreas Zoephel

24

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30 April 2020

Alexander Weiss-Puxbaum

25

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30 April 2020

Guido Boehmelt

28

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30 April 2020

Joerg Rinnenthal

29

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30 April 2020

Heribert Arnhof

30

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30 April 2020

Nicola Wiechens

31

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30 April 2020

Meng-Ying Wu

32

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30 April 2020

Tom Owen-Hughes

33

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30 April 2020

Mark Pearson

35

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30 April 2020

publication date

10 June 2019

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30 April 2020

published in

Nature Chemical Biology

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30 April 2020

volume

15

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30 April 2020

issue

7

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30 April 2020

page(s)

672-680

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Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7

30 April 2020

cites work

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Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

11 February 2021

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Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach

11 February 2021

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression

11 February 2021

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Delineating the role of cooperativity in the design of potent PROTACs for BTK.

11 February 2021

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Plasticity in binding confers selectivity in ligand-induced protein degradation

11 February 2021

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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands.

11 February 2021

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

11 February 2021

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Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders

11 February 2021

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Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

11 February 2021

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Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-

11 February 2021

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening

11 February 2021

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Defining a Cancer Dependency Map.

11 February 2021

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Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds

11 February 2021

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Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands.

11 February 2021

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Mammalian SWI/SNF complexes in cancer: emerging therapeutic opportunities

11 February 2021

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Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway

11 February 2021

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Structural basis of PROTAC cooperative recognition for selective protein degradation

11 February 2021

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Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis

11 February 2021

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The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer

11 February 2021

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Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex

11 February 2021

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Identification of a Chemical Probe for Family VIII Bromodomains through Optimization of a Fragment Hit

11 February 2021

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Small-Molecule PROTACS: New Approaches to Protein Degradation

11 February 2021

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Selective targeting of the BRG/PB1 bromodomains impairs embryonic and trophoblast stem cell maintenance.

11 February 2021

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Mammalian SWI/SNF chromatin remodeling complexes and cancer: Mechanistic insights gained from human genomics

11 February 2021

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The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

11 February 2021

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Catalytic in vivo protein knockdown by small-molecule PROTACs.

11 February 2021

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

11 February 2021

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

11 February 2021

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DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

11 February 2021

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Ultrasensitive proteome analysis using paramagnetic bead technology

11 February 2021

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Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

11 February 2021

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Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation

11 February 2021

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An optimized microRNA backbone for effective single-copy RNAi

11 February 2021

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Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

11 February 2021

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A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.

11 February 2021

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Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

11 February 2021

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The spectrum of SWI/SNF mutations, ubiquitous in human cancers

11 February 2021

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Dissecting Fragment-Based Lead Discovery at the von Hippel-Lindau Protein:Hypoxia Inducible Factor 1α Protein-Protein Interface

11 February 2021

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Histone recognition and large-scale structural analysis of the human bromodomain family

11 February 2021

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Data processing and analysis with the autoPROC toolbox

11 February 2021

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Andromeda: a peptide search engine integrated into the MaxQuant environment

11 February 2021

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Features and development of Coot

11 February 2021

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11 February 2021

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MolProbity: all-atom structure validation for macromolecular crystallography

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

Phasercrystallographic software

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

Retrieval of crystallographically-derived molecular geometry information.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

The CCP4 suite: programs for protein crystallography

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6600871

10.1038/S41589-019-0294-6

11 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31178587%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31178587%20AND%20SRC:MED&resulttype=core&format=json

30 April 2020

PubMed publication ID

31178587

1 reference