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Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
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Europe PubMed Central
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6092238
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28 March 2020
title
Biological Role and Therapeutic Potential of IDH Mutations in Cancer
(English)
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Europe PubMed Central
PMC publication ID
6092238
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
author
Bill H Diplas
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2
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Europe PubMed Central
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6092238
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28 March 2020
author name string
Matthew S Waitkus
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1
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Europe PubMed Central
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6092238
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
Hai Yan
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3
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Europe PubMed Central
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6092238
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
publication date
24 May 2018
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Europe PubMed Central
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6092238
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retrieved
28 March 2020
published in
Cancer Cell
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stated in
Europe PubMed Central
PMC publication ID
6092238
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
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28 March 2020
volume
34
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Europe PubMed Central
PMC publication ID
6092238
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28 March 2020
issue
2
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6092238
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28 March 2020
page(s)
186-195
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Europe PubMed Central
PMC publication ID
6092238
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28 March 2020
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IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition
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Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma
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A vaccine targeting mutant IDH1 induces antitumour immunity
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Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
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Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.
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7 September 2018
Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.
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7 September 2018
Quantitative metabolome analysis profiles activation of glutaminolysis in glioma with IDH1 mutation
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7 September 2018
Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations.
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7 September 2018
IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection
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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.
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Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate
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7 September 2018
Spontaneous loss of heterozygosity leading to homozygous R132H in a patient-derived IDH1 mutant cell line
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7 September 2018
Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia
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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible
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7 September 2018
Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.
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7 September 2018
IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives
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7 September 2018
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function
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7 September 2018
A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation.
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7 September 2018
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
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7 September 2018
IDH mutation impairs histone demethylation and results in a block to cell differentiation
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PubMed Central
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7 September 2018
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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7 September 2018
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
IDH2 mutations are frequent in angioimmunoblastic T-cell lymphoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Frequent mutation of isocitrate dehydrogenase (IDH)1 and IDH2 in cholangiocarcinoma identified through broad-based tumor genotyping
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
An in vivo patient-derived model of endogenous IDH1-mutant glioma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
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7 September 2018
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
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7 September 2018
Glioma IDH1 mutation patterns off the beaten track.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Recurring mutations found by sequencing an acute myeloid leukemia genome
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
IDH1 and IDH2 mutations in gliomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Role of cytosolic NADP+-dependent isocitrate dehydrogenase in ischemia-reperfusion injury in mouse kidney
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
An integrated genomic analysis of human glioblastoma multiforme
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
The genomic landscapes of human breast and colorectal cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6092238
retrieved
7 September 2018
Multiple NADPH-producing pathways control glutathione (GSH) content in retina
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/29805076
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CCELL.2018.04.011
1 reference
stated in
Europe PubMed Central
PMC publication ID
6092238
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
PMC publication ID
6092238
1 reference
stated in
Europe PubMed Central
PMC publication ID
6092238
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
PubMed publication ID
29805076
1 reference
stated in
Europe PubMed Central
PMC publication ID
6092238
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29805076%20AND%20SRC:MED&resulttype=core&format=json
retrieved
28 March 2020
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