(Q29615366)

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17 January 2020

title

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21130701

30 April 2017

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17 January 2020

1 reference

1 reference

1 reference

1

1 reference

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17 January 2020

Omar Abdel-Wahab

2

1 reference

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17 January 2020

Patrick S. Ward

4

1 reference

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17 January 2020

18

Elisabeth Paietta

1 reference

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17 January 2020

24

Craig B Thompson

1 reference

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17 January 2020

author name string

Chao Lu

3

1 reference

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17 January 2020

Jay Patel

5

1 reference

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17 January 2020

Alan Shih

6

1 reference

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17 January 2020

Yushan Li

7

1 reference

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17 January 2020

Neha Bhagwat

8

1 reference

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17 January 2020

Aparna Vasanthakumar

9

1 reference

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17 January 2020

Hugo F Fernandez

10

1 reference

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17 January 2020

Martin S Tallman

11

1 reference

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17 January 2020

Zhuoxin Sun

12

1 reference

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17 January 2020

Kristy Wolniak

13

1 reference

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17 January 2020

Justine K Peeters

14

1 reference

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17 January 2020

Wei Liu

15

1 reference

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17 January 2020

Sung E Choe

16

1 reference

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17 January 2020

Valeria R Fantin

17

1 reference

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17 January 2020

Bob Löwenberg

19

1 reference

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17 January 2020

Jonathan D Licht

20

1 reference

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17 January 2020

Lucy A Godley

21

1 reference

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17 January 2020

Ruud Delwel

22

1 reference

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17 January 2020

Peter J M Valk

23

1 reference

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17 January 2020

Ross L Levine

25

1 reference

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17 January 2020

Ari Melnick

26

1 reference

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17 January 2020

language of work or name

1 reference

30 April 2017

publication date

9 December 2010

1 reference

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17 January 2020

2 references

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30 April 2017

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17 January 2020

volume

18

2 references

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30 April 2017

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17 January 2020

issue

6

2 references

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30 April 2017

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17 January 2020

page(s)

553-567

1 reference

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Comprehensive methylome map of lineage commitment from haematopoietic progenitors

17 January 2020

cites work

1 reference

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Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

30 April 2017

1 reference

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Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

30 April 2017

1 reference

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Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy

30 April 2017

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

30 April 2017

1 reference

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Recurring mutations found by sequencing an acute myeloid leukemia genome

30 April 2017

1 reference

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Mutation in TET2 in myeloid cancers

30 April 2017

1 reference

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Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

30 April 2017

1 reference

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

IDH1 and IDH2 mutations in gliomas

30 April 2017

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Comparative isoschizomer profiling of cytosine methylation: the HELP assay

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

30 April 2017

1 reference

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Histone demethylation by a family of JmjC domain-containing proteins

30 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Probing tumor phenotypes using stable and regulated synthetic microRNA precursors

30 April 2017

1 reference

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Gene Expression Omnibus: NCBI gene expression and hybridization array data repository

30 April 2017

1 reference

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Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.

30 April 2017

1 reference

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Active DNA demethylation: many roads lead to Rome.

3 June 2018

1 reference

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IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

3 June 2018

1 reference

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IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

3 June 2018

1 reference

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IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

3 June 2018

1 reference

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DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia.

3 June 2018

1 reference

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Anthracycline dose intensification in acute myeloid leukemia

3 June 2018

1 reference

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Acquired mutations in TET2 are common in myelodysplastic syndromes

3 June 2018

1 reference

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PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure

3 June 2018

1 reference

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Design of a genome-wide siRNA library using an artificial neural network

3 June 2018

1 reference

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IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

Pharmacokinetic measurements of IDN 5390 using electrospray ionization tandem mass spectrometry: structure characterization and quantification in dog plasma.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4105845

10.1016/J.CCR.2010.11.015

26 November 2018

Identifiers

DOI

3 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21130701

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21130701%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21130701

3 references

30 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21130701%20AND%20SRC:MED&resulttype=core&format=json

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=21130701

17 January 2020

PubMed publication ID

3 references

30 April 2017