(Q54527804)

30 May 2018

http://europepmc.org/abstract/MED/22358332

title

PI3K signalling: the path to discovery and understanding. (English)

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

1

Bart Vanhaesebroeck

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

author name string

Len Stephens

series ordinal

2

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

Phillip Hawkins

series ordinal

3

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

publication date

23 February 2012

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

published in

Nature Reviews Molecular Cell Biology

1 reference

30 May 2018

http://europepmc.org/abstract/MED/22358332

volume

13

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30 May 2018

http://europepmc.org/abstract/MED/22358332

issue

3

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30 May 2018

http://europepmc.org/abstract/MED/22358332

page(s)

195-203

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30 May 2018

http://europepmc.org/abstract/MED/22358332

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

31 March 2020

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

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A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain

31 March 2020

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Increased phosphorylation of Akt substrate of 160 kDa (AS160) in rat skeletal muscle in response to insulin or contractile activity

31 March 2020

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

31 March 2020

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

31 March 2020

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31 March 2020

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Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

31 March 2020

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PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

31 March 2020

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31 March 2020

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Role of translocation in the activation and function of protein kinase B

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Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase

31 March 2020

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Phosphatidylinositol 3-kinase-gamma activates Bruton's tyrosine kinase in concert with Src family kinases

31 March 2020

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Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

31 March 2020

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Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

31 March 2020

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Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains

31 March 2020

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

31 March 2020

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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

31 March 2020

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Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools

31 March 2020

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Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

31 March 2020

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Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

31 March 2020

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Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger

31 March 2020

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EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

31 March 2020

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FYVE fingers bind PtdIns(3)P

31 March 2020

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A functional PtdIns(3)P-binding motif

31 March 2020

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Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains

31 March 2020

1 reference

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Phox homology domains specifically bind phosphatidylinositol phosphates.

31 March 2020

1 reference

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PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

31 March 2020

1 reference

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The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

31 March 2020

1 reference

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Phox domain interaction with PtdIns(3)P targets the Vam7 t-SNARE to vacuole membranes.

31 March 2020

1 reference

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Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae

31 March 2020

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The emerging mechanisms of isoform-specific PI3K signalling

31 March 2020

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The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

31 March 2020

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Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

31 March 2020

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Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

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Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

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Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

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A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Germline mutations in PTEN are present in Bannayan-Zonana syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

High frequency of mutations of the PIK3CA gene in human cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Mutation of the PIK3CA gene in ovarian and breast cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Myotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Myotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

PI 3-kinase p110beta: a new target for antithrombotic therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Structural insights into phosphoinositide 3-kinase catalysis and signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Disruption of PDGF receptor trafficking by mutation of its PI-3 kinase binding sites.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

p110δ, a novel phosphoinositide 3-kinase in leukocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3290

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

The phosphatidylinositol 3'-kinase p85alpha gene is an oncogene in human ovarian and colon tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Purification and characterization of phosphoinositide 3-kinase from rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Membrane ruffling and chemotaxis transduced by the PDGF beta-receptor require the binding site for phosphatidylinositol 3' kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Two types of phosphatidylinositol 3-kinase from bovine thymus. Monomer and heterodimer form

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Distinct specificity in the recognition of phosphoinositides by the pleckstrin homology domains of dynamin and Bruton's tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Transient increase in phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol trisphosphate during activation of human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

FYVE and coiled-coil domains determine the specific localisation of Hrs to early endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

Involvement of phosphoinositide 3-kinase in insulin- or IGF-1-induced membrane ruffling

1 reference

https://pubmed.ncbi.nlm.nih.gov/22358332

12 December 2020

https://api.fatcat.wiki/v0/release/nslpth5n5jhxppazis4zq6nzne

Identifiers

1 reference

30 July 2022

mapped directly with Wikidata item

Fatcat ID

release_nslpth5n5jhxppazis4zq6nzne

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nslpth5n5jhxppazis4zq6nzne

30 July 2022

mapped directly with Wikidata item