(Q29547860)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

review article

1 reference

title

The phosphatidylinositol 3-Kinase AKT pathway in human cancer (English)

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1

1 reference

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10 November 2019

author name string

Charles L Sawyers

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

10 November 2019

language of work or name

1 reference

23 April 2017

publication date

1 July 2002

1 reference

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10 November 2019

published in

Nature Reviews Cancer

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

volume

2

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

issue

7

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

page(s)

489-501

2 references

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23 April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

10 November 2019

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The IRS-signalling system: a network of docking proteins that mediate insulin action

31 March 2020

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p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

31 March 2020

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Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells

31 March 2020

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Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

31 March 2020

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

31 March 2020

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

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The activation of phosphatidylinositol 3-kinase by Ras

31 March 2020

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Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

31 March 2020

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

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The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

31 March 2020

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Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

31 March 2020

1 reference

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

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Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

31 March 2020

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

31 March 2020

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Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

31 March 2020

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SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

31 March 2020

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Cellular survival: a play in three Akts

31 March 2020

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PKB/AKT: functional insights from genetic models

31 March 2020

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Role of translocation in the activation and function of protein kinase B

31 March 2020

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

31 March 2020

1 reference

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Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

31 March 2020

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

31 March 2020

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The protooncogene TCL1 is an Akt kinase coactivator

31 March 2020

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Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

31 March 2020

1 reference

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Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

31 March 2020

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Modulation of Akt kinase activity by binding to Hsp90

31 March 2020

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Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

31 March 2020

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Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

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Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

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NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

31 March 2020

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Induction of NF-kappaB by the Akt/PKB kinase

31 March 2020

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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

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Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

31 March 2020

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

31 March 2020

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

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Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

31 March 2020

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Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

31 March 2020

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Wortmannin inhibits serum-induced activation of phosphoinositide 3-kinase and proliferation of CHRF-288 cells

31 March 2020

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PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

31 March 2020

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TOR, a central controller of cell growth

31 March 2020

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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

31 March 2020

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

31 March 2020

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

31 March 2020

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Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

31 March 2020

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Mammalian TOR: a homeostatic ATP sensor

31 March 2020

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dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

31 March 2020

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Phosphorylation and activation of p70s6k by PDK1

31 March 2020

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Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

31 March 2020

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Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

31 March 2020

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Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

31 March 2020

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Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

31 March 2020

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Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

31 March 2020

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Role of the PI3K regulatory subunit in the control of actin organization and cell migration

31 March 2020

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Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

31 March 2020

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Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

31 March 2020

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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

31 March 2020

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PIK3CA is implicated as an oncogene in ovarian cancer.

31 March 2020

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Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

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Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

31 March 2020

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Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

31 March 2020

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Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

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Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

31 March 2020

1 reference

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A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.

31 March 2020

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Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

31 March 2020

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

31 March 2020

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

31 March 2020

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

31 March 2020

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Akt/protein kinase B promotes organ growth in transgenic mice

31 March 2020

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Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

31 March 2020

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Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

31 March 2020

1 reference

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

31 March 2020

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

31 March 2020

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

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Pten is essential for embryonic development and tumour suppression

31 March 2020

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Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia

31 March 2020

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Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

31 March 2020

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Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study

31 March 2020

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Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

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Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

31 March 2020

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W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

31 March 2020

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Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

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An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

1 reference

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Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

31 March 2020

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Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

31 March 2020

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PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

31 March 2020

1 reference

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation

31 March 2020

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Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

31 March 2020

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The TOR signaling cascade regulates gene expression in response to nutrients

31 March 2020

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Regulation of longevity and stress resistance by Sch9 in yeast

31 March 2020

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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

31 March 2020

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daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

31 March 2020

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A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

31 March 2020

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

31 March 2020

1 reference

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The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Drosophila S6 kinase: a regulator of cell size

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Weakening link to colorectal cancer?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Identification of PTEN mutations in metastatic melanoma specimens

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRC839

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

31 March 2020

Identifiers

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12094235%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 November 2019

1014023118

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=12094235

3 references

23 April 2017

Consolidated OpenCitations Corpus – April 2017