(Q33774967)

29 July 2017

1 reference

title

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity (English)

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29 July 2017

Ali IU

1

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29 July 2017

Schriml LM

series ordinal

2

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29 July 2017

Dean M

series ordinal

3

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29 July 2017

language of work or name

English

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publication date

1 November 1999

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Journal of the National Cancer Institute

29 July 2017

published in

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29 July 2017

volume

91

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29 July 2017

issue

22

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29 July 2017

page(s)

1922-1932

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

29 July 2017

cites work

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Allelic imbalance, including deletion of PTEN/MMACI, at the Cowden disease locus on 10q22-23, in hamartomas from patients with Cowden syndrome and germline PTEN mutation

21 January 2018

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Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Pten is essential for embryonic development and tumour suppression

21 January 2018

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Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

21 January 2018

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Microsatellite instability in sporadic endometrial carcinoma

21 January 2018

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Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado.

21 January 2018

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PTEN1 is frequently mutated in primary endometrial carcinomas

21 January 2018

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Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles

21 January 2018

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Frameshift mutation: determinants of specificity

21 January 2018

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A tiger behind many doors: multiple genetic pathways to malignant glioma

21 January 2018

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Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations

21 January 2018

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PTEN/MMAC1 mutations in primary glioblastomas and short-term cultures of malignant gliomas.

21 January 2018

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21 January 2018

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Somatic deletion mapping on chromosome 10 and sequence analysis of PTEN/MMAC1 point to the 10q25-26 region as the primary target in low-grade and high-grade gliomas

21 January 2018

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21 January 2018

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PTEN (MMAC1) mutations are frequent in primary glioblastomas (de novo) but not in secondary glioblastomas

21 January 2018

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21 January 2018

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Distinct patterns of deletion on 10p and 10q suggest involvement of multiple tumor suppressor genes in the development of astrocytic gliomas of different malignancy grades.

21 January 2018

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DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours

21 January 2018

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Mutation in the mismatch repair gene Msh6 causes cancer susceptibility

21 January 2018

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PTEN/MMAC1/TEP1 involvement in primary prostate cancers.

21 January 2018

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Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

21 January 2018

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Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas

21 January 2018

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Mutational analysis of the PTEN gene in head and neck squamous cell carcinoma

21 January 2018

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Distinct regions of allelic imbalance on chromosome 10q22-q26 in squamous cell carcinomas of the lung

21 January 2018

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PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers

21 January 2018

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Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

21 January 2018

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Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma

21 January 2018

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Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers

21 January 2018

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p53 and APC gene mutations: software and databases

21 January 2018

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The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

21 January 2018

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Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

21 January 2018

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The coordinated action of protein tyrosine phosphatases and kinases in cell signaling

21 January 2018

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Phosphatases and tumorigenesis

21 January 2018

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P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

21 January 2018

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

21 January 2018

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

21 January 2018

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Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

21 January 2018

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma

21 January 2018

1 reference

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PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

21 January 2018

1 reference

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The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2F91.22.1922

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

21 January 2018

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Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

21 January 2018

1 reference

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PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

21 January 2018

1 reference

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High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1093/JNCI/91.22.1922

1 reference

29 July 2017

1 reference