(Q34276940)

1 August 2017

title

Akt/protein kinase B promotes organ growth in transgenic mice (English)

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1 August 2017

7

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1 August 2017

4

Pamela S Douglas

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1 August 2017

Tetsuo Shioi

1

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1 August 2017

Julie R McMullen

2

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1 August 2017

Peter M Kang

3

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1 August 2017

Toshiyuki Obata

5

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1 August 2017

Thomas F Franke

6

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1 August 2017

Seigo Izumo

8

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1 August 2017

language of work or name

English

0 references

publication date

1 April 2002

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Molecular and Cellular Biology

1 August 2017

published in

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1 August 2017

volume

22

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1 August 2017

issue

8

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1 August 2017

page(s)

2799-2809

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 August 2017

cites work

1 reference

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

6 July 2018

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Regulation of translation initiation by FRAP/mTOR

6 July 2018

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Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

6 July 2018

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Growth hormone and the heart

6 July 2018

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Rapamycin in transplantation: a review of the evidence

6 July 2018

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A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

6 July 2018

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TOR, a central controller of cell growth

6 July 2018

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Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy

6 July 2018

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

6 July 2018

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Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

6 July 2018

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A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells

6 July 2018

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

6 July 2018

1 reference

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The conserved phosphoinositide 3-kinase pathway determines heart size in mice

6 July 2018

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Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

6 July 2018

1 reference

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

6 July 2018

1 reference

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The PI3K-PDK1 connection: more than just a road to PKB

6 July 2018

1 reference

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The genetic control of organ growth: insights from Drosophila.

6 July 2018

1 reference

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Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

6 July 2018

1 reference

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Phosphorylation and regulation of Raf by Akt (protein kinase B)

6 July 2018

1 reference

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Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

6 July 2018

1 reference

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Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Size control in animal development

6 July 2018

1 reference

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Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

6 July 2018

1 reference

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Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Regulation of protein kinase C zeta by PI 3-kinase and PDK-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

De novo-developed T cells have compromised response to existing alloantigens: using Ld-specific transgenic 2C T cells as tracers in a mouse heart transplantation model

6 July 2018

1 reference

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Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Essential role for protein kinase B (PKB) in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Disruption of IRS-2 causes type 2 diabetes in mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Determination of the specific substrate sequence motifs of protein kinase C isozymes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Mechanism of activation of protein kinase B by insulin and IGF-1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

6 July 2018

1 reference

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Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein

6 July 2018

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Role of insulin-like growth factors in embryonic and postnatal growth

6 July 2018

1 reference

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

6 July 2018

1 reference

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Isolation and characterization of the mouse cardiac myosin heavy chain genes.

6 July 2018

1 reference

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Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Drosophila S6 kinase: a regulator of cell size

28 October 2018

1 reference

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Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Mortality and cancer incidence in acromegaly: a retrospective cohort study. United Kingdom Acromegaly Study Group.

28 October 2018

1 reference

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TOR signalling and control of cell growth

28 October 2018

1 reference

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The Drosophila insulin receptor is required for normal growth

28 October 2018

1 reference

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

28 October 2018

1 reference

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=133704

Pathology of the heart in acromegaly: anatomic findings in 27 autopsied patients

28 October 2018

1 reference

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Rapamycin inhibits alpha 1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase

28 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Transgenic expression of green fluorescence protein can cause dilatedcardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Survey of studies examining mammalian cardiomyocyte DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Murine recipients of fully mismatched donor marrow are protected from lethal graft-versus-host disease by the in vivo administration of rapamycin but develop an autoimmune-like syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Rapamycin selectively inhibits angiotensin II-induced increase in protein synthesis in cardiac myocytes in vitro. Potential role of 70-kD S6 kinase in angiotensin II-induced cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Transgenic remodeling of the contractile apparatus in the mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

The immunosuppressive effect of rapamycin on mouse small bowel transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

Cardiomyocyte DNA synthesis and binucleation during murine development

1 reference

https://pubmed.ncbi.nlm.nih.gov/11909972

12 December 2020

10.1128/MCB.22.8.2799-2809.2002

Identifiers

DOI

1 reference

1 August 2017

1 reference

1 August 2017

1 reference