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(Q36888160)
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The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore.
scientific article published on 8 January 2013
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3667973
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23312823%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
review article
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title
The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore
(English)
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Europe PubMed Central
PMC publication ID
3667973
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23312823%20AND%20SRC:MED&resulttype=core&format=json
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22 February 2020
author
John A Cidlowski
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2
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3667973
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22 February 2020
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John M Busillo
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1
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Europe PubMed Central
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3667973
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22 February 2020
publication date
8 January 2013
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22 February 2020
published in
Trends in Endocrinology and Metabolism
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3667973
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22 February 2020
volume
24
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22 February 2020
issue
3
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3667973
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22 February 2020
page(s)
109-119
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3667973
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22 February 2020
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29 September 2017
The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Gene regulation by the glucocorticoid receptor: structure:function relationship
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Glucocorticoids inhibit the transcriptional activity of LEF/TCF in differentiating osteoblasts in a glycogen synthase kinase-3beta-dependent and -independent manner
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Nuclear factor-kappaB: its role in health and disease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
CBP (CREB binding protein) integrates NF-kappaB (nuclear factor-kappaB) and glucocorticoid receptor physical interactions and antagonism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Glucocorticoids act within minutes to inhibit recruitment of signalling factors to activated EGF receptors through a receptor-dependent, transcription-independent mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
The steroid and thyroid hormone receptor superfamily
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
29 September 2017
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
27 June 2018
Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
27 June 2018
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
27 June 2018
Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
27 June 2018
Peripheral T cells are the therapeutic targets of glucocorticoids in experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
4 September 2018
Novel mouse strain with Cre recombinase in 11beta-hydroxysteroid dehydrogenase-2-expressing cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
4 September 2018
Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
4 September 2018
Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3667973
retrieved
4 December 2018
Interactions between the immune and neuroendocrine systems
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Glucocorticoids increase interleukin-6-dependent gene induction by interfering with the expression of the suppressor of cytokine signaling 3 feedback inhibitor
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Glucocorticoid repression of AP-1 is not mediated by competition for nuclear coactivators
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A new function for the C-terminal zinc finger of the glucocorticoid receptor. Repression of RelA transactivation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23312823
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.TEM.2012.11.005
1 reference
stated in
Europe PubMed Central
PMC publication ID
3667973
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23312823%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PMC publication ID
3667973
1 reference
stated in
Europe PubMed Central
PMC publication ID
3667973
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23312823%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
PubMed publication ID
23312823
1 reference
stated in
Europe PubMed Central
PMC publication ID
3667973
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23312823%20AND%20SRC:MED&resulttype=core&format=json
retrieved
22 February 2020
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