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October 2024

Feeding on a Moorish gecko (Tarentola mauritanica). Mendoza-Roldan et al., 2024

Image Credit: Jairo Alfonso Mendoza Roldan

Research Articles

Sequential early-life viral infections modulate the microbiota and adaptive immune responses to systemic and mucosal vaccination

Yuhao Li, Jerome M. Molleston, Crystal Lovato, Jasmine Wright, Isabel Erickson, Duyen Bui, Andrew H. Kim, Harshad Ingle, Somya Aggarwal, Lila S. Nolan, Ahmed O. Hassan, Lynne Foster, Michael S. Diamond, Megan T. Baldridge

2’-O-methyltransferase-deficient yellow fever virus: Restricted replication in the midgut and secondary tissues of Aedes aegypti mosquitoes severely limits dissemination

Anja vom Hemdt, Alexandra L. Thienel, Katrin Ciupka, Janett Wieseler, Hannah M. Proksch, Martin Schlee, Beate M. Kümmerer

The five homologous CiaR-controlled Ccn sRNAs of Streptococcus pneumoniae modulate Zn-resistance

Nicholas R. De Lay, Nidhi Verma, Dhriti Sinha, Abigail Garrett, Maximillian K. Osterberg, Daisy Porter, Spencer Reiling, David P. Giedroc, Malcolm E. Winkler

Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes

Mitch Brinkkemper, Gius Kerster, Philip J. M. Brouwer, Andy S. Tran, Jonathan L. Torres, Roos A. Ettema, Haye Nijhuis, Joel D. Allen, Wenwen Zhu, Hongmei Gao, Wen-Hsin Lee, Tom P. L. Bijl, Jonne L. Snitselaar, Judith A. Burger, Ilja Bontjer, Wouter Olijhoek, Rashmi Ravichandran, Marielle J. van Breemen, Iván Del Moral-Sánchez, Ronald Derking, Kwinten Sliepen, Gabriel Ozorowski, Max Crispin, David C. Montefiori, Mathieu Claireaux, Andrew B. Ward, Marit J. van Gils, Neil P. King, Rogier W. Sanders

Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis

Poornima Sankar, Ramon Bossardi Ramos, Jamie Corro, Lokesh K. Mishra, Tanvir Noor Nafiz, Gunapati Bhargavi, Mohd Saqib, Sibongiseni K. L. Poswayo, Suraj P. Parihar, Yi Cai, Selvakumar Subbian, Anil K. Ojha, Bibhuti B. Mishra

Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

Thiago DeSouza-Vieira, Marco Antônio M. Pretti, Phillipe Souza Lima Gomes, Heitor A. Paula-Neto, Amy Goundry, Michelle T. Nascimento, Sundar Ganesan, Triciana Gonçalves da Silva, Olena Kamenyeva, Juraj Kabat, Javier Manzella-Lapeira, Fábio B. Canto, Vanderlei da Silva Fraga-Junior, Mateus Eustáquio Lopes, Leonardo Gomes Vaz, Gabriela Pessenda, Andrea Paun, Anita L. Freitas-Mesquita, José Roberto Meyer-Fernandes, Mariana Boroni, Maria Bellio, Gustavo Batista Menezes, Joseph Brzostowski, Jeremy Mottram, David Sacks, Ana Paula C. A. Lima, Elvira M. Saraiva

Saurian-associated Leishmania tarentolae in dogs: Infectivity and immunogenicity evaluation in the canine model

Jairo Alfonso Mendoza-Roldan, Ilaria Varotto-Boccazzi, Viviane Noll Louzada-Flores, Alec Evans, Imad Bouzaidi Cheikhi, Mariaelisa Carbonara, Andrea Zatelli, Sara Epis, Claudio Bandi, Frédéric Beugnet, Domenico Otranto

Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate

Danielle L. Porier, Awadalkareem Adam, Lin Kang, Pawel Michalak, Juselyn Tupik, Matthew A. Santos, Manette Tanelus, Krisangel López, Dawn I. Auguste, Christy Lee, Irving C. Allen, Tian Wang, Albert J. Auguste

Distinct chikungunya virus polymerase palm subdomains contribute to viral protein accumulation and virion production

Marie-France Martin, Boris Bonaventure, Nia E. McCray, Olve B. Peersen, Kathryn Rozen-Gagnon, Kenneth A. Stapleford

Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cells

J. Natalie Howard, Callie Levinger, Selase Deletsu, Rémi Fromentin, Nicolas Chomont, Alberto Bosque, for the AIDS Clinical Trials Group (ACTG) A5325 Team

A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens

Kabo R. Wale, Nicky O’Boyle, Rebecca E. McHugh, Ester Serrano, David R. Mark, Gillian R. Douce, James P. R. Connolly, Andrew J. Roe

Characterisation of the antibody-mediated selective pressure driving intra-host evolution of SARS-CoV-2 in prolonged infection

Michael Schoefbaenker, Theresa Günther, Eva Ulla Lorentzen, Marie-Luise Romberg, Marc Tim Hennies, Rieke Neddermeyer, Marlin Maybrit Müller, Alexander Mellmann, Chiara Robin Bojarzyn, Georg Lenz, Matthias Stelljes, Eike Roman Hrincius, Richard Vollenberg, Stephan Ludwig, Phil-Robin Tepasse, Joachim Ewald Kühn

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection

Zhao Huang, Cuiying Kong, WenBo Zhang, Jianyi You, Chenyang Gao, Jiangnan Yi, Zhanzhuo Mai, Xiongnan Chen, Pei Zhou, Lang Gong, Guihong Zhang, Heng Wang

Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus

Fengjuan Li, Shanquan Wu, Lv Lv, Shulun Huang, Zelin Zhang, Zhaxi Zerang, Pinghua Li, Yimei Cao, Huifang Bao, Pu Sun, Xingwen Bai, Yong He, Yuanfang Fu, Hong Yuan, Xueqing Ma, Zhixun Zhao, Jing Zhang, Jian Wang, Tao Wang, Dong Li, Qiang Zhang, Jijun He, Zaixin Liu, Zengjun Lu, Dongsheng Lei, Kun Li

Host 5-HT affects Plasmodium transmission in mosquitoes via modulating mosquito mitochondrial homeostasis

Li Gao, Benguang Zhang, Yuebiao Feng, Wenxu Yang, Shibo Zhang, Jingwen Wang

High phenotypic diversity correlated with genomic variation across the European Batrachochytrium salamandrivorans epizootic

Moira Kelly, Christina A. Cuomo, Wouter Beukema, Salvador Carranza, Jesse Erens, Marleen Foubert, Zhimin Li, Stefan Lötters, Vanessa Schulz, Sebastian Steinfartz, Sarah Van Praet, Michael Veith, Frank Pasmans, An Martel

Swine NONO promotes IRF3-mediated antiviral immune response by Detecting PRRSV N protein

Dandan Jiang, Chao Sui, Xiangju Wu, Ping Jiang, Juan Bai, Yue Hu, Xiaoyan Cong, Juntong Li, Dongwan Yoo, Laura C. Miller, Changhee Lee, Yijun Du, Jing Qi

8-Oxoguanine DNA Glycosylase1 conceals oxidized guanine in nucleoprotein-associated RNA of respiratory syncytial virus

Lang Pan, Ke Wang, Wenjing Hao, Yaoyao Xue, Xu Zheng, Ritwika S. Basu, Tapas K. Hazra, Azharul Islam, Yashoda Hosakote, Bing Tian, Matthieu G. Gagnon, Xueqing Ba, Istvan Boldogh

Monocyte-regulated interleukin 12 production drives clearance of Staphylococcus aureus

Adeline Peignier, Jisun Kim, Alexander Lemenze, Dane Parker

Resistance to Cry14A family Bacillus thuringiensis crystal proteins in Caenornabditis elegans operates via the nhr-31 transcription factor and vacuolar-type ATPase pathway

Youmie Kim, Thanh-Thanh Nguyen, Daniel J. Durning, Takao Ishidate, Ozkan Aydemir, Craig C. Mello, Yan Hu, Theodore W. Kahn, Raffi V. Aroian

BglaTNB6, a tailocin produced by a plant-associated nonpathogenic bacterium, prevents rice seed-borne bacterial diseases

Yusuke Kouzai, Yoshiyuki Sagehashi, Riku Watanabe, Hideyuki Kajiwara, Nobuhiro Suzuki, Hiroshi Ono, Ken Naito, Chiharu Akimoto-Tomiyama

Distinct mechanisms of type 3 secretion system recognition control LTB4 synthesis in neutrophils and macrophages

Amanda Brady, Leonardo C. Mora Martinez, Benjamin Hammond, Kaitlyn M. Whitefoot-Keliin, Bodduluri Haribabu, Silvia M. Uriarte, Matthew B. Lawrenz

Linkage-specific ubiquitin binding interfaces modulate the activity of the chlamydial deubiquitinase Cdu1 towards poly-ubiquitin substrates

Jan Schlötzer, Alexander Schmalix, Sophie Hügelschäffer, Dominic Rieger, Florian Sauer, Mark D. Tully, Thomas Rudel, Silke Wiesner, Caroline Kisker

Mlf mediates proteotoxic response via formation of cellular foci for protein folding and degradation in Giardia

Martina Vinopalová, Lenka Arbonová, Zoltán Füssy, Vít Dohnálek, Abdul Samad, Tomáš Bílý, Marie Vancová, Pavel Doležal

Features that matter: Evolutionary signatures can predict viral transmission routes

Maya Wardeh, Jack Pilgrim, Melody Hui, Aurelia Kotsiri, Matthew Baylis, Marcus S. C. Blagrove

The host tropism of current zoonotic H7N9 viruses depends mainly on an acid-labile hemagglutinin with a single amino acid mutation in the stalk region

Tomo Daidoji, Hiroki Sadakane, Kotaro Garan, Norihito Kawashita, Yasuha Arai, Yohei Watanabe, Takaaki Nakaya

Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression

Elliott D. SoRelle, Lauren E. Haynes, Katherine A. Willard, Beth Chang, James Ch’ng, Heather Christofk, Micah A. Luftig

Caspase-1 in Cx3cr1-expressing cells drives an IL-18-dependent T cell response that promotes parasite control during acute Toxoplasma gondii infection

Isaac W. Babcock, Lydia A. Sibley, Sydney A. Labuzan, Maureen N. Cowan, Ish Sethi, Seblework Alemu, Abigail G. Kelly, Michael A. Kovacs, John R. Lukens, Tajie H. Harris

The full transcription map of cottontail rabbit papillomavirus in tumor tissues

Pengfei Jiang, Vladimir Majerciak, Jiafen Hu, Karla Balogh, Thomas J. Meyer, Maggie Cam, Debra Shearer, Matthew Lanza, Neil D. Christensen, Zhi-Ming Zheng

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I

Jiaoyang Li, Jing Zhang, Pu Sun, Jian Wang, Guoxiu Li, Zhanding Cui, Dong Li, Hong Yuan, Tao Wang, Kun Li, Xingwen Bai, Zhixun Zhao, Yimei Cao, Xueqing Ma, Pinghua Li, Yuanfang Fu, Huifang Bao, Zaixin Liu, Shuqi Xiao, Xinglong Wang, Zengjun Lu

Potent broadly neutralizing antibodies mediate efficient antibody-dependent phagocytosis of HIV-infected cells

Brian J. Snow, Nida K. Keles, Michael W. Grunst, Sanath Kumar Janaka, Ryan T. Behrens, David T. Evans

Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens

Raphael A. Reyes, Louise Turner, Isaac Ssewanyana, Prasanna Jagannathan, Margaret E. Feeney, Thomas Lavstsen, Bryan Greenhouse, Sebastiaan Bol, Evelien M. Bunnik

Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Felicitas Ruiz, William B. Foreman, Michelle Lilly, Viren A. Baharani, Delphine M. Depierreux, Vrasha Chohan, Ashley L. Taylor, Jamie Guenthoer, Duncan Ralph, Frederick A. Matsen IV, Helen Y. Chu, Paul D. Bieniasz, Marceline Côté, Tyler N. Starr, Julie Overbaugh

The protein segregase VCP/p97 promotes host antifungal defense via regulation of SYK activation

Zhugui Shao, Li Wang, Limin Cao, Tian Chen, Xin-Ming Jia, Wanwei Sun, Chengjiang Gao, Hui Xiao

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

Guillermo Najarro, Kevin Brackett, Hunter Woosley, Leah C. Dorman, Vincent Turon-Lagot, Sudip Khadka, Catya Faeldonea, Osvaldo Kevin Moreno, Adriana Ramirez Negron, Christina Love, Ryan Ward, Charles Langelier, Frank McCarthy, Carlos Gonzalez, Joshua E. Elias, Brooke M. Gardner, Carolina Arias

A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

Letícia Tiburcio Ferreira, Gustavo Capatti Cassiano, Luis Carlos Salazar Alvarez, John Okombo, Juliana Calit, Diana Fontinha, Eva Gil-Iturbe, Rachael Coyle, Carolina Horta Andrade, Per Sunnerhagen, Daniel Youssef Bargieri, Miguel Prudêncio, Matthias Quick, Pedro V. Cravo, Marcus C. S. Lee, David A. Fidock, Fabio Trindade Maranhão Costa

Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1

Tyron Chang, Jessica Alvarez, Sruthi Chappidi, Stacey Crockett, Mahsa Sorouri, Robert C. Orchard, Dustin C. Hancks

From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona

Emma V. Waters, Winnie W. Y. Lee, Amina Ismail Ahmed, Marie-Anne Chattaway, Gemma C. Langridge

A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

Lijun Wang, Zhe Wang, Hua Zhang, Qian Jin, Shuaihua Fan, Yanni Liu, Xueting Huang, Jun Guo, Chao Cai, Jing-ren Zhang, Hui Wu

B cell receptor dependent enhancement of dengue virus infection

Chad Gebo, Céline S. C. Hardy, Benjamin D. McElvany, Nancy R. Graham, Joseph Q. Lu, Shima Moradpour, Jeffrey R. Currier, Heather Friberg, Gregory D. Gromowski, Stephen J. Thomas, Gary C. Chan, Sean A. Diehl, Adam T. Waickman

Dynamic composition of stress granules in Trypanosoma brucei

Htay Mon Aye, Feng-Jun Li, Cynthia Y. He