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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category)
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{protein
{{Infobox_gene}}
|Name=tropomodulin 2 (neuronal)

|caption=
'''Tropomodulin 2 (neuronal)''' also known as '''TMOD2''' is a [[protein]] which in humans is encoded by the ''TMOD2'' [[gene]].<ref name="pmid10662549">{{cite journal|author-link2=Huda Zoghbi | vauthors = Cox PR, Zoghbi HY | title = Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs | journal = Genomics | volume = 63 | issue = 1 | pages = 97–107 |date=January 2000 | pmid = 10662549 | doi = 10.1006/geno.1999.6061 }}</ref>
|image=
|width=
|HGNCid=11872
|Symbol=TMOD2
|AltSymbols=
|EntrezGene=29767
|OMIM=602928
|RefSeq= NM_014548
|UniProt= Q9NZR1
|PDB=
|ECnumber=
|Chromosome=15
|Arm=q
|Band=21.2
|LocusSupplementaryData=
}}
'''Tropomodulin 2 (neuronal)''' also known as TMOD2 is a [[protein]] which in humans is encoded by the TMOD2 [[gene]].<ref name="pmid10662549">{{cite journal | author = Cox PR, Zoghbi HY | title = Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs | journal = Genomics | volume = 63 | issue = 1 | pages = 97–107 | year = 2000 | month = January | pmid = 10662549 | doi = 10.1006/geno.1999.6061 | url = | issn = }}</ref>


== Function ==
== Function ==


This gene encodes a neuronal-specific member of the [[tropomodulin]] family of [[actin]]-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with [[tropomyosin]]. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: TMOD2 , Tropomodulin 2 (neuronal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29767 | accessdate = }}</ref>
This gene encodes a neuronal-specific member of the [[tropomodulin]] family of [[actin]]-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with [[tropomyosin]]. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29767 }}</ref>


== References ==
== References ==
{{Reflist}}
{{Reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2002 |pmid= 12477932 |doi= 10.1073/pnas.242603899 |pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal |vauthors=Pawlak G, McGarvey TW, Nguyen TB, etal |title=Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder. |journal=Int. J. Cancer |volume=110 |issue= 3 |pages= 368–73 |year= 2004 |pmid= 15095301 |doi= 10.1002/ijc.20151 |s2cid=875146 }}
*{{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 |pmc=1356129 }}
*{{cite journal |vauthors=Watakabe A, Kobayashi R, Helfman DM |title=N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin. |journal=J. Cell Sci. |volume=109 |issue= 9|pages= 2299–310 |year= 1996 |doi=10.1242/jcs.109.9.2299 |pmid= 8886980 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 |pmc=528928 }}
*{{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
{{refend}}


{{NLM content}}
{{NLM content}}

{{Cytoskeletal Proteins}}

[[Category:Tropomodulin]]


{{gene-15-stub}}
{{gene-15-stub}}

Latest revision as of 02:07, 4 March 2023

TMOD2
Identifiers
AliasesTMOD2, N-TMOD, NTMOD, tropomodulin 2
External IDsOMIM: 602928; MGI: 1355335; HomoloGene: 22817; GeneCards: TMOD2; OMA:TMOD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014548
NM_001142885

NM_001038710
NM_016711

RefSeq (protein)

NP_001136357
NP_055363

NP_001033799
NP_057920

Location (UCSC)Chr 15: 51.75 – 51.82 MbChr 9: 75.47 – 75.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.[5]

Function

[edit]

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128872Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032186Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID 10662549.
  6. ^ "Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)".

Further reading

[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.