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NEFM

From Wikipedia, the free encyclopedia
NEFM
Identifiers
AliasesNEFM, NEF3, NF-M, NFM, neurofilament, medium polypeptide, neurofilament medium, neurofilament medium chain
External IDsOMIM: 162250; MGI: 97314; HomoloGene: 38041; GeneCards: NEFM; OMA:NEFM - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005382
NM_001105541

NM_008691

RefSeq (protein)

NP_001099011
NP_005373

NP_032717

Location (UCSC)Chr 8: 24.91 – 24.92 MbChr 14: 68.32 – 68.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[5][6]

Function

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Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the exoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000104722Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022054Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ding Y, Reed DR, Baltazar MC, Price RA (May 1992). "RFLP for BgI II at the human neurofilament medium chain (NEF3) gene locus". Nucleic Acids Res. 20 (6): 1429. doi:10.1093/nar/20.6.1429-a. PMC 312205. PMID 1348579.
  6. ^ a b "Entrez Gene: NEFM neurofilament, medium polypeptide 150kDa".

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.