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Herpesviridae

(Redirected from Orthoherpesviridae)

Herpesviridae is a large family of DNA viruses that cause infections and certain diseases in animals, including humans.[1][2][3] The members of this family are also known as herpesviruses. The family name is derived from the Greek word ἕρπειν (herpein 'to creep'), referring to spreading cutaneous lesions, usually involving blisters, seen in flares of herpes simplex 1, herpes simplex 2 and herpes zoster (shingles).[4] In 1971, the International Committee on the Taxonomy of Viruses (ICTV) established Herpesvirus as a genus with 23 viruses among four groups.[5] As of 2020, 115 species are recognized, all but one of which are in one of the three subfamilies.[6] Herpesviruses can cause both latent and lytic infections.

Herpesviridae
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Subfamilies and genera

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Nine herpesvirus types are known to primarily infect humans,[7] at least five of which are extremely widespread among most human populations, and which cause common diseases: herpes simplex 1 and 2 (HSV-1 and HSV-2, also known as HHV-1 and HHV-2; both of which can cause orolabial and genital herpes), varicella zoster (or HHV-3; the cause of chickenpox and shingles), Epstein–Barr (EBV or HHV-4; implicated in several diseases, including mononucleosis and some cancers), and human cytomegalovirus (HCMV or HHV-5). More than 90% of adults have been infected with at least one of these, and a latent form of the virus remains in almost all humans who have been infected.[8][9][10] Other human herpesviruses are human herpesvirus 6A and 6B (HHV-6A and HHV-6B) and human herpesvirus 7 (HHV-7), which are the etiological agents for Roseola, and HHV-8 (also known as KSHV) which is responsible for causing Kaposi's sarcoma-associated herpesvirus.[7] HHV here stands for "Human Herpesvirus".

In total, more than 130 herpesviruses are known,[11] some of them from mammals, birds, fish, reptiles, amphibians, and molluscs.[7] Among the animal herpesviruses are pseudorabies virus causing Aujeszky's disease in pigs, and bovine herpesvirus 1 causing bovine infectious rhinotracheitis and pustular vulvovaginitis.

Taxonomy

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Additionally, the species Iguanid herpesvirus 2 is currently unassigned to a genus and subfamily.[6]

See Herpesvirales#Taxonomy for information on taxonomic history, phylogenetic research, and the nomenclatural system.

Structure

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Schematic drawing of a Herpesviridae virion

All members of the Herpesviridae share a common structure; a relatively large, monopartite, double-stranded, linear DNA genome encoding 100–200 genes encased within an icosahedral protein cage (with T=16 symmetry) called the capsid, which is itself wrapped in a protein layer called the tegument containing both viral proteins and viral mRNAs and a lipid bilayer membrane called the envelope. This whole particle is known as a virion. The structural components of a typical HSV virion are the Lipid bilayer envelope, Tegument, DNA, Glycoprotein spikes and Nucleocapsid. The four-component Herpes simplex virion encompasses the double-stranded DNA genome into an icosahedral nucleocapsid. There is tegument around. Tegument contains filaments, each 7 nm wide. It is an amorphous layer with some structured regions. Finally, it is covered with a lipoprotein envelope. There are spikes made of glycoprotein protruding from each virion. These can expand the diameter of the virus to 225 nm. The diameters of virions without spikes are around 186 nm. There are at least two unglycosylated membrane proteins in the outer envelope of the virion. There are also 11 glycoproteins. These are gB, gC, gD, gE, gG, gH, gI, gJ, gK, gL and gM. Tegument contains 26 proteins. They have duties such as capsid transport to the nucleus and other organelles, activation of early gene transcription, and mRNA degradation. The icosahedral nucleocapsid is similar to that of tailed bacteriophage in the order Caudovirales. This capsid has 161 capsomers consisting of 150 hexons and 11 pentons, as well as a portal complex that allows entry and exit of DNA into the capsid.[12][13]

Life cycle

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All herpesviruses are nuclear-replicating—the viral DNA is transcribed to mRNA within the infected cell's nucleus.[citation needed]

Infection is initiated when a viral particle contacts a cell with specific types of receptor molecules on the cell surface. Following binding of viral envelope glycoproteins to cell membrane receptors, the virion is internalized and dismantled, allowing viral DNA to migrate to the cell nucleus. Within the nucleus, replication of viral DNA and transcription of viral genes occurs.[citation needed]

During symptomatic infection, infected cells transcribe lytic viral genes. In some host cells, a small number of viral genes termed latency-associated transcript (LAT) accumulate, instead. In this fashion, the virus can persist in the cell (and thus the host) indefinitely. While primary infection is often accompanied by a self-limited period of clinical illness, long-term latency is symptom-free.[citation needed]

Chromatin dynamics regulate the transcription competency of entire herpes virus genomes. When the virus enters a cell, the cellular immune response is to protect the cell. The cell does so by wrapping the viral DNA around histones and condensing it into chromatin, causing the virus to become dormant, or latent. If cells are unsuccessful and the chromatin is loosely bundled, the viral DNA is still accessible. The viral particles can turn on their genes and replicate using cellular machinery to reactivate, starting a lytic infection.[14]

Reactivation of latent viruses has been implicated in a number of diseases (e.g. shingles, pityriasis rosea). Following activation, transcription of viral genes transitions from LAT to multiple lytic genes; these lead to enhanced replication and virus production. Often, lytic activation leads to cell death. Clinically, lytic activation is often accompanied by emergence of nonspecific symptoms, such as low-grade fever, headache, sore throat, malaise, and rash, as well as clinical signs such as swollen or tender lymph nodes and immunological findings such as reduced levels of natural killer cells.[citation needed]

In animal models, local trauma and system stress have been found to induce reactivation of latent herpesvirus infection. Cellular stressors like transient interruption of protein synthesis and hypoxia are also sufficient to induce viral reactivation.[15]

Genus Subfamily Host details Tissue tropism Entry details Release details Replication site Assembly site Transmission
Iltovirus α Birds: galliform: psittacine None Cell receptor endocytosis Budding Nucleus Nucleus Oral-fecal, aerosol
Proboscivirus β Elephants None Glycoproteins Budding Nucleus Nucleus Contact
Cytomegalovirus β Humans; monkeys Epithelial mucosa, hematopoietic (blood) lineage cells Glycoproteins Budding Nucleus Nucleus Urine, saliva
Mardivirus α Chickens; turkeys; quail None Cell receptor endocytosis Budding Nucleus Nucleus Aerosol
Rhadinovirus γ Humans; mammals B-lymphocytes Glycoproteins Budding Nucleus Nucleus Sex, saliva
Macavirus γ Mammals B-lymphocytes Glycoproteins Budding Nucleus Nucleus Sex, saliva
Roseolovirus β Humans T-cells; B-cells; NK-cell; monocytes; macrophages; epithelial Glycoproteins Budding Nucleus Nucleus Respiratory contact
Simplexvirus α Humans; mammals Epithelial mucosa Cell receptor endocytosis Budding Nucleus Nucleus Sex, saliva
Scutavirus α Sea turtles None Cell receptor endocytosis Budding Nucleus Nucleus Aerosol
Varicellovirus α Mammals Epithelial mucosa Glycoproteins Budding Nucleus Nucleus Aerosol
Percavirus γ Mammals B-lymphocytes Glycoproteins Budding Nucleus Nucleus Sex, saliva
Lymphocryptovirus γ Humans; mammals B-lymphocytes Glycoproteins Budding Nucleus Nucleus Saliva
Muromegalovirus β Rodents Salivary glands Glycoproteins Budding Nucleus Nucleus Contact

Evolution

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The three mammalian subfamilies – Alpha-, Beta- and Gamma-herpesviridae – arose approximately 180 to 220 mya.[16] The major sublineages within these subfamilies were probably generated before the mammalian radiation of 80 to 60 mya. Speciations within sublineages took place in the last 80 million years probably with a major component of cospeciation with host lineages.[citation needed]

All the currently known bird and reptile species are alphaherpesviruses. Although the branching order of the herpes viruses has not yet been resolved, because herpes viruses and their hosts tend to coevolve this is suggestive that the alphaherpesviruses may have been the earliest branch.[citation needed]

The time of origin of the genus Iltovirus has been estimated to be 200 mya while those of the mardivirus and simplex genera have been estimated to be between 150 and 100 mya.[17]

Immune system evasions

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Herpesviruses are known for their ability to establish lifelong infections. One way this is possible is through immune evasion. Herpesviruses have many different ways of evading the immune system. One such way is by encoding a protein mimicking human interleukin 10 (hIL-10) and another is by downregulation of the major histocompatibility complex II (MHC II) in infected cells.

cmvIL-10

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Research conducted on cytomegalovirus (CMV) indicates that the viral human IL-10 homolog, cmvIL-10, is important in inhibiting pro-inflammatory cytokine synthesis. The cmvIL-10 protein has 27% identity with hIL-10 and only one conserved residue out of the nine amino acids that make up the functional site for cytokine synthesis inhibition on hIL-10. There is, however, much similarity in the functions of hIL-10 and cmvIL-10. Both have been shown to down regulate IFN-γ, IL-1α, GM-CSF, IL-6 and TNF-α, which are all pro-inflammatory cytokines. They have also been shown to play a role in downregulating MHC I and MHC II and up regulating HLA-G (non-classical MHC I). These two events allow for immune evasion by suppressing the cell-mediated immune response and natural killer cell response, respectively. The similarities between hIL-10 and cmvIL-10 may be explained by the fact that hIL-10 and cmvIL-10 both use the same cell surface receptor, the hIL-10 receptor. One difference in the function of hIL-10 and cmvIL-10 is that hIL-10 causes human peripheral blood mononuclear cells (PBMC) to both increase and decrease in proliferation whereas cmvIL-10 only causes a decrease in proliferation of PBMCs. This indicates that cmvIL-10 may lack the stimulatory effects that hIL-10 has on these cells.[18]

It was found that cmvIL-10 functions through phosphorylation of the Stat3 protein. It was originally thought that this phosphorylation was a result of the JAK-STAT pathway. However, despite evidence that JAK does indeed phosphorylate Stat3, its inhibition has no significant influence on cytokine synthesis inhibition. Another protein, PI3K, was also found to phosphorylate Stat3. PI3K inhibition, unlike JAK inhibition, did have a significant impact on cytokine synthesis. The difference between PI3K and JAK in Stat3 phosphorylation is that PI3K phosphorylates Stat3 on the S727 residue whereas JAK phosphorylates Stat3 on the Y705 residue. This difference in phosphorylation positions seems to be the key factor in Stat3 activation leading to inhibition of pro-inflammatory cytokine synthesis. In fact, when a PI3K inhibitor is added to cells, the cytokine synthesis levels are significantly restored. The fact that cytokine levels are not completely restored indicates there is another pathway activated by cmvIL-10 that is inhibiting cytokine system synthesis. The proposed mechanism is that cmvIL-10 activates PI3K which in turn activates PKB (Akt). PKB may then activate mTOR, which may target Stat3 for phosphorylation on the S727 residue.[19]

MHC downregulation

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Another one of the many ways in which herpes viruses evade the immune system is by down regulation of MHC I and MHC II. This is observed in almost every human herpesvirus. Down regulation of MHC I and MHC II can come about by many different mechanisms, most causing the MHC to be absent from the cell surface. As discussed above, one way is by a viral chemokine homolog such as IL-10. Another mechanism to down regulate MHCs is to encode viral proteins that detain the newly formed MHC in the endoplasmic reticulum (ER). The MHC cannot reach the cell surface and therefore cannot activate the T cell response. The MHCs can also be targeted for destruction in the proteasome or lysosome. The ER protein TAP also plays a role in MHC down regulation. Viral proteins inhibit TAP preventing the MHC from picking up a viral antigen peptide. This prevents proper folding of the MHC and therefore the MHC does not reach the cell surface.[20]

Human herpesvirus types

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Below are the nine distinct viruses in this family known to cause disease in humans.[21][22][23]

Human herpesvirus (HHV) classification[1][22]
Name Synonym Subfamily Primary Target Cell Syndrome Site of Latency Means of Spread
HHV‑1 Herpes simplex virus-1 (HSV-1) α (Alpha) Mucoepithelial Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, encephalitis, as well as other herpes simplex infections Neuron (sensory ganglia) Close contact (oral or sexually transmitted infection)
HHV-2 Herpes simplex virus-2 (HSV-2) α Mucoepithelial Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, Mollaret's meningitis, as well as other herpes simplex infections Neuron (sensory ganglia) Close contact (oral or sexually transmitted infection)
HHV-3 Varicella zoster virus (VZV) α Mucoepithelial Chickenpox and shingles Neuron (sensory ganglia) Respiratory and close contact (including sexually transmitted infection)
HHV-4 Epstein–Barr virus (EBV) Lymphocryptovirus γ (Gamma) B cells and epithelial cells Severe mosquito bite allergy, Epstein-Barr virus-positive reactive lymphoid hyperplasia, Infectious mononucleosis, Burkitt's lymphoma, Epstein–Barr virus-positive Hodgkin lymphoma, extranodal NK/T cell lymphoma, nasal type, Epstein–Barr virus-associated aggressive NK cell leukemia, CNS lymphoma in AIDS patients, post-transplant lymphoproliferative syndrome (PTLD), nasopharyngeal carcinoma, HIV-associated hairy leukoplakia, multiple sclerosis B cell Close contact, transfusions, tissue transplant, and congenital
HHV-5 Cytomegalovirus (CMV) β (Beta) Monocytes and epithelial cells Infectious mononucleosis-like syndrome,[24] retinitis Monocyte, and ? Saliva, urine, blood, breast milk
HHV-6A and 6B Roseolovirus β T cells and ? Sixth disease (roseola infantum or exanthem subitum) T cells and ? Respiratory and close contact?
HHV-7 β T cells and ? drug-induced hypersensitivity syndrome, encephalopathy, hemiconvulsion-hemiplegia-epilepsy syndrome, hepatitis infection, postinfectious myeloradiculoneuropathy, pityriasis rosea, and the reactivation of HHV-4 (EBV), leading to "mononucleosis-like illness" T cells and ? ?
HHV-8 Kaposi's sarcoma-associated herpesvirus
(KSHV), a type of Rhadinovirus		 γ Lymphocyte and other cells Kaposi's sarcoma, primary effusion lymphoma, some types of multicentric Castleman's disease B cell Close contact (sexual), saliva?

Zoonotic herpesviruses

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In addition to the herpesviruses considered endemic in humans, some viruses associated primarily with animals may infect humans. These are zoonotic infections:

Zoonotic herpesviruses
Species Type Synonym Subfamily Human Pathophysiology
Macaque monkey CeHV-1 Cercopithecine herpesvirus 1, (monkey B virus) α Very unusual, with only approximately 25 human cases reported.[25] Untreated infection is often deadly; sixteen of the 25 cases resulted in fatal encephalomyelitis. At least four cases resulted in survival with severe neurologic impairment.[25][26] Symptom awareness and early treatment are important for laboratory workers facing exposure.[27]
Mouse MuHV-4 Murid herpesvirus 68 (MHV-68) γ Zoonotic infection more common in laboratory workers handling infected mice.[28][29] ELISA tests show factor-of-four (x4) false positive results, due to antibody cross-reaction with other herpesviruses.[28]

Animal herpesviruses

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In animal virology, the best known herpesviruses belong to the subfamily Alphaherpesvirinae. Research on pseudorabies virus (PrV), the causative agent of Aujeszky's disease in pigs, has pioneered animal disease control with genetically modified vaccines. PrV is now extensively studied as a model for basic processes during lytic herpesvirus infection, and for unraveling molecular mechanisms of herpesvirus neurotropism, whereas bovine herpesvirus 1, the causative agent of bovine infectious rhinotracheitis and pustular vulvovaginitis, is analyzed to elucidate molecular mechanisms of latency. The avian infectious laryngotracheitis virus is phylogenetically distant from these two viruses and serves to underline similarity and diversity within the Alphaherpesvirinae.[2][3]

Research

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Main article: Herpes simplex research

Research is currently ongoing into a variety of side-effect or co-conditions related to the herpesviruses. These include:[citation needed]

See also

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References

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  2. ^ a b Mettenleiter; et al. (2008). "Molecular Biology of Animal Herpesviruses". Animal Viruses: Molecular Biology. Caister Academic Press. ISBN 978-1-904455-22-6. {{cite book}}: |website= ignored (help)
  3. ^ a b Sandri-Goldin RM, ed. (2006). Alpha Herpesviruses: Molecular and Cellular Biology. Caister Academic Press. ISBN 978-1-904455-09-7. {{cite book}}: |website= ignored (help)
  4. ^ Beswick TS (1962). "The Origin and the Use of the Word Herpes". Med Hist. 6 (3): 214–232. doi:10.1017/S002572730002737X. PMC 1034725. PMID 13868599.
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  6. ^ a b "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021.
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  9. ^ In the United States, as many as 15% of adults between 35 and 72 years of age have been infected. Archived 20 April 2012 at the Wayback Machine National Center for Infectious Diseases
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  11. ^ Brown JC, Newcomb WW (August 2011). "Herpesvirus capsid assembly: insights from structural analysis". Current Opinion in Virology. 1 (2): 142–9. doi:10.1016/j.coviro.2011.06.003. PMC 3171831. PMID 21927635.
  12. ^ Liu, Y., Jih, J., Dai, X. et al. Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. Nature 570, 257–261 (2019). https://doi.org/10.1038/s41586-019-1248-6
  13. ^ Das, D., & Hong, J. (2019). Herpesvirus Polymerase Inhibitors. In Viral Polymerases (pp. 333–356). Elsevier. https://doi.org/10.1016/B978-0-12-815422-9.00012-7
  14. ^ Hu M, Depledge DP, Flores Cortes E, Breuer J, Schang LM (November 2019). "Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections". PLOS Pathogens. 15 (11): e1008076. doi:10.1371/journal.ppat.1008076. PMC 6855408. PMID 31725813.
  15. ^ Grinde B (October 2013). "Herpesviruses: latency and reactivation – viral strategies and host response". Journal of Oral Microbiology. 5 (1): 22766. doi:10.3402/jom.v5i0.22766. PMC 3809354. PMID 24167660.
  16. ^ McGeoch DJ, Cook S, Dolan A, Jamieson FE, Telford EA (March 1995). "Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses". Journal of Molecular Biology. 247 (3): 443–58. doi:10.1006/jmbi.1995.0152. PMID 7714900.
  17. ^ McGeoch DJ, Rixon FJ, Davison AJ (April 2006). "Topics in herpesvirus genomics and evolution". Virus Research. 117 (1): 90–104. doi:10.1016/j.virusres.2006.01.002. PMID 16490275.
  18. ^ Spencer JV, Lockridge KM, Barry PA, Lin G, Tsang M, Penfold ME, Schall TJ (February 2002). "Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10". Journal of Virology. 76 (3): 1285–92. doi:10.1128/JVI.76.3.1285-1292.2002. PMC 135865. PMID 11773404.
  19. ^ Spencer JV (February 2007). "The cytomegalovirus homolog of interleukin-10 requires phosphatidylinositol 3-kinase activity for inhibition of cytokine synthesis in monocytes". Journal of Virology. 81 (4): 2083–6. doi:10.1128/JVI.01655-06. PMC 1797587. PMID 17121792.
  20. ^ Lin A, Xu H, Yan W (April 2007). "Modulation of HLA expression in human cytomegalovirus immune evasion". Cellular & Molecular Immunology. 4 (2): 91–8. PMID 17484802.
  21. ^ Adams MJ, Carstens EB (July 2012). "Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012)". Archives of Virology. 157 (7): 1411–22. doi:10.1007/s00705-012-1299-6. PMC 7086667. PMID 22481600.
  22. ^ a b Whitley RJ (1996). Baron S; et al. (eds.). Herpesviruses. in: Baron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. ISBN 0-9631172-1-1.
  23. ^ Murray PR, Rosenthal KS, Pfaller MA (2005). Medical Microbiology (5th ed.). Elsevier Mosby. ISBN 978-0-323-03303-9.
  24. ^ Bottieau E, Clerinx J, Van den Enden E, Van Esbroeck M, Colebunders R, Van Gompel A, Van den Ende J (2006). "Infectious mononucleosis-like syndromes in febrile travelers returning from the tropics". Journal of Travel Medicine. 13 (4): 191–7. doi:10.1111/j.1708-8305.2006.00049.x. PMID 16884400.
  25. ^ a b Weigler BJ (February 1992). "Biology of B virus in macaque and human hosts: a review". Clinical Infectious Diseases. 14 (2): 555–67. doi:10.1093/clinids/14.2.555. PMID 1313312.
  26. ^ Huff JL, Barry PA (February 2003). "B-virus (Cercopithecine herpesvirus 1) infection in humans and macaques: potential for zoonotic disease". Emerging Infectious Diseases. 9 (2): 246–50. doi:10.3201/eid0902.020272. PMC 2901951. PMID 12603998.
  27. ^ Herpes-B Fact Sheet Archived 6 January 2008 at the Wayback Machine
  28. ^ a b Hricová M, Mistríková J (2007). "Murine gammaherpesvirus 68 serum antibodies in general human population". Acta Virologica. 51 (4): 283–7. PMID 18197737.
  29. ^ Wang Y, Tibbetts SA, Krug LT (29 September 2021). "Conquering the Host: Determinants of Pathogenesis Learned from Murine Gammaherpesvirus 68". Annual Review of Virology. 8 (1): 349–371. doi:10.1146/annurev-virology-011921-082615. ISSN 2327-056X. PMC 9153731. PMID 34586873.
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