Structural Biology and Molecular Biophysics

Structural Biology and Molecular Biophysics

eLife reviews research that uses techniques including X-ray crystallography, cryo-EM and single-molecule methods. Learn more about what we review and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Structural Biology and Molecular Biophysics
    2. Plant Biology

    Molecular dynamics simulations illuminate the role of sequence context in the ELF3-PrD-based temperature sensing mechanism in plants

    Richard J Lindsay, Rafael Giordano Viegas ... Sonya M Hanson
    Not yet revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPARγ

    Jinsai Shang, Douglas J Kojetin
    Commonly used covalent PPARγ inhibitors weaken, but do not block, binding of other ligands via an allosteric mechanism where ligands clash with a covalent ligand-induced transcriptionally repressive structural conformation.
    1. Structural Biology and Molecular Biophysics

    Protonation/deprotonation-driven switch for the redox stability of low-potential [4Fe-4S] ferredoxin

    Kei Wada, Kenji Kobayashi ... Masaki Unno
    Not yet revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Structure of human PIEZO1 and its slow inactivating channelopathy mutants

    Yuanyue Shan, Xinyi Guo ... Duanqing Pei
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Biochemical and structural insights into the auto-inhibited state of Mical1 and its activation by Rab8

    Amrita Rai, Petra Janning ... Roger S Goody
    Not yet revised
    Reviewed Preprint v1
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics of a nicotinic receptor neurotransmitter site

    Mrityunjay Singh, Dinesh C Indurthi ... Shailendra Asthana
    Revised
    Reviewed Preprint v3
    Updated
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Impact of the clinically approved BTK inhibitors on the conformation of full-length BTK and analysis of the development of BTK resistance mutations in chronic lymphocytic leukemia

    Raji E Joseph, Thomas E Wales ... Amy H Andreotti
    Revised
    Reviewed Preprint v2
    Updated
    1. Structural Biology and Molecular Biophysics

    Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

    Yuanyuan Wang, Fan Xu ... Yongning He
    The binding site and potential mechanism of human SCARF1 for lipoprotein recognition are identified by combining the crystal structural determination of the N-terminal fragments and biochemical and cellular assays.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Isobaric crosslinking mass spectrometry technology for studying conformational and structural changes in proteins and complexes

    Jie Luo, Jeff Ranish
    A novel pair of isobaric crosslinking reagents is described, which allow relative quantification of crosslinker-modified peptides during mass spectrometry analysis for comparative structural studies of proteins and protein complexes.
    1. Structural Biology and Molecular Biophysics

    Direct and indirect salt effects on homotypic phase separation

    Matt MacAinsh, Souvik Dey, Huan-Xiang Zhou
    All-atom molecular dynamics simulations revealed both direct and indirect salt effects and led to an amino-acid composition-based predictor for four classes of salt dependence of IDP phase separation.
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Highlights

    1. Structural Biology and Molecular Biophysics
    2. Cell Biology
    3. Biochemistry and Chemical Biology

    Allosteric Regulation of Kinase Activity – call for papers

    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Modelling biomolecular condensates

    Furqan Dar, Rohit Pappu
    1. Structural Biology and Molecular Biophysics

    Same structure, different mechanisms?

    Francis TF Tsai, Christopher P Hill

Senior editors

  1. Amy H Andreotti
    Iowa State University, United States
  2. Felix Campelo
    The Institute of Photonic Sciences, Spain
  3. Kenton J Swartz
    National Institute of Neurological Disorders and Stroke, NIH, United States
  4. See more editors