PURB
Izgled
Transkripcijski aktivatorski protein Pur-beta je protein koji je kod ljudi kodiran genom PURB.[5][6]
Aminokiselinska sekvenca
Dužina polipeptidnog lanca je 312 aminokiselina, а molekulska težina 33.241 Da.[7]
10 | 20 | 30 | 40 | 50 | ||||
---|---|---|---|---|---|---|---|---|
MADGDSGSER | GGGGGPCGFQ | PASRGGGEQE | TQELASKRLD | IQNKRFYLDV | ||||
KQNAKGRFLK | IAEVGAGGSK | SRLTLSMAVA | AEFRDSLGDF | IEHYAQLGPS | ||||
SPEQLAAGAE | EGGGPRRALK | SEFLVRENRK | YYLDLKENQR | GRFLRIRQTV | ||||
NRGGGGFGAG | PGPGGLQSGQ | TIALPAQGLI | EFRDALAKLI | DDYGGEDDEL | ||||
AGGPGGGAGG | PGGGLYGELP | EGTSITVDSK | RFFFDVGCNK | YGVFLRVSEV | ||||
KPSYRNAITV | PFKAWGKFGG | AFCRYADEMK | EIQERQRDKL | YERRGGGSGG | ||||
GEESEGEEVD | ED |
Funkcija
Ovaj genski proizvod je sekvencnospecifični protein koji se vezuje za jednolančanu sekvencu DNK. Preferirano se veže za jedan lanac purin-bogatog elementa zvanog PUR, koji je prisutan na početku replikacije i u regijama koje okružuju gene u raznim eukariotima, od kvasaca do ljudi.
Stoga je uključen u kontrolu i replikacije i transkripcije DNK. Delecija ovog gena povezana je s mijelodisplazijskim sindromom i akutnom mijelogenom leukemijom.[6]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000146676 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000094483 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Bergemann AD, Ma ZW, Johnson EM (Dec 1992). "Sequence of cDNA comprising the human pur gene and sequence-specific single-stranded-DNA-binding properties of the encoded protein". Mol Cell Biol. 12 (12): 5673–82. doi:10.1128/mcb.12.12.5673. PMC 360507. PMID 1448097.
- ^ a b "Entrez Gene: PURB purine-rich element binding protein B".
- ^ "UniProt, Q96QR8" (jezik: engleski). Pristupljeno 28. 9. 2021.
Dopunska literatura
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Kelm RJ, Cogan JG, Elder PK, et al. (1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". J. Biol. Chem. 274 (20): 14238–45. doi:10.1074/jbc.274.20.14238. PMID 10318844.
- Lezon-Geyda K, Najfeld V, Johnson EM (2001). "Deletions of PURA, at 5q31, and PURB, at 7p13, in myelodysplastic syndrome and progression to acute myelogenous leukemia". Leukemia. 15 (6): 954–62. doi:10.1038/sj.leu.2402108. PMID 11417483.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
- Gupta M, Sueblinvong V, Raman J, et al. (2004). "Single-stranded DNA-binding proteins PURalpha and PURbeta bind to a purine-rich negative regulatory element of the alpha-myosin heavy chain gene and control transcriptional and translational regulation of the gene expression. Implications in the repression of alpha-myosin heavy chain during heart failure". J. Biol. Chem. 278 (45): 44935–48. doi:10.1074/jbc.M307696200. PMID 12933792.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.