URG4

URG4
Identifikatori
Aliasi	URGCP
Vanjski ID-jevi	OMIM: 610337 MGI: 1919296 HomoloGene: 69243 GeneCards: URGCP
Lokacija gena (čovjek)
Hrom.	Hromosom 7 (čovjek)
Kraj	43,926,411 bp
Lokacija gena (miš)
Hrom.	Hromosom 11 (miš)
Kraj	5,712,376 bp
Obrazac RNK ekspresije
	Više referentnih podataka o ekspresiji
Ontologija gena
Molekularna funkcija	• GTP binding;
Ćelijska komponenta	• citoplazma; • jedro; • citosol;
Biološki proces	• ćelijski ciklus;
	Izvori:Amigo / QuickGO
Ortolozi
	55665
	72046
	ENSG00000106608
	ENSMUSG00000049680
	Q8TCY9
	Q5NCI0
	NM_017920; NM_001077663; NM_001077664; NM_001290075; NM_001290076
NM_001077661; NM_178623; NM_001361588; NM_001361589; NM_001361590;
	NM_001361591; NM_001361592
	NP_001071131; NP_001071132; NP_001277004; NP_001277005; NP_060390
NP_001071129; NP_848738; NP_001348517; NP_001348518; NP_001348519;
	NP_001348520; NP_001348521
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Pregledana verzija ove stranice, odobrena dana 15 april 2023, zasnovana je na ovoj izmjeni.

Nadregulirani gen 4, znan i kao URG4, jest ljudski gen.^[5]

Aminokiselinska sekvenca

Dužina nukleotidnog lanca je 931 aminokiselina, а molekulska težina 104.987 Da.^[6]

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MASPGIEVEL	LGKGHSDLGE	VAPEIKASER	RTAVAIADLE	WREMEGDDCE
FRYGDGTNEA	QDNDFPTVER	SRLQEMLSLL	GLETYQVQKL	SLQDSLQISF
DSMKNWAPQV	PKDLPWNFLR	KLQALNADAR	NTTMVLDVLP	DARPVEKESQ
MEEEIIYWDP	ADDLAADIYS	FSELPTPDTP	VNPLDLLCAL	LLSSDSFLQQ
EIALKMALCQ	FALPLVLPDS	ENHYHTFLLW	AMRGIVRTWW	SQPPRGMGSF
REDSVVLSRA	PAFAFVRMDV	SSNSKSQLLN	AVLSPGHRQW	DCFWHRDLNL
GTNAREISDG	LVEISWFFPS	GREDLDIFPE	PVAFLNLRGD	IGSHWLQFKL
LTEISSAVFI	LTDNISKKEY	KLLYSMKEST	TKYYFILSPY	RGKRNTNLRF
LNKLIPVLKI	DHSHVLVKVS	STDSDSFVKR	IRAIVGNVLR	APCRRVSVED
MAHAARKLGL	KVDEDCEECQ	KAKDRMERIT	RKIKDSDAYR	RDELRLQGDP
WRKAAQVEKE	FCQLQWAVDP	PEKHRAELRR	RLLELRMQQN	GHDPSSGVQE
FISGISSPSL	SEKQYFLRWM	EWGLARVAQP	RLRQPPETLL	TLRPKHGGTT
DVGEPLWPEP	LGVEHFLREM	GQFYEAESCL	VEAGRLPAGQ	RRFAHFPGLA
SELLLTGLPL	ELIDGSTLSM	PVRWVTGLLK	ELHVRLERRS	RLVVLSTVGV
PGTGKSTLLN	TMFGLRFATG	KSCGPRGAFM	QLITVAEGFS	QDLGCDHILV
IDSGGLIGGA	LTSAGDRFEL	EASLATLLMG	LSNVTVISLA	ETKDIPAAIL
HAFLRLEKTG	HMPNYQFVYQ	NLHDVSVPGP	RPRDKRQLLD	PPGDLSRAAA
QMEKQGDGFR	ALAGLAFCDP	EKQHIWHIPG	LWHGAPPMAA	VSLAYSEAIF
ELKRCLLENI	RNGLSNQNKN	IQQLIELVRR	L

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106608 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049680 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: URG4 up-regulated gene 4".
^ "UniProt, Q8TCY9" (jezik: engleski). Pristupljeno 27. 9. 2021.

Dopunska literatura

Song J, Xie H, Lian Z, Yang G, Du R, Du Y, Zou X, Jin H, Gao J, Liu J, Fan D (decembar 2006). "Enhanced cell survival of gastric cancer cells by a novel gene URG4". Neoplasia. 8 (12): 995–1002. doi:10.1593/neo.06592. PMC 1783723. PMID 17217616.
Tsang HT, Connell JW, Brown SE, Thompson A, Reid E, Sanderson CM (septembar 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (august 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Fu GK, Wang JT, Yang J, Au-Young J, Stuve LL (juli 2004). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.
Tufan NL, Lian Z, Liu J, Pan J, Arbuthnot P, Kew M, Clayton MM, Zhu M, Feitelson MA (2003). "Hepatitis Bx antigen stimulates expression of a novel cellular gene, URG4, that promotes hepatocellular growth and survival". Neoplasia. 4 (4): 355–68. doi:10.1038/sj.neo.7900241. PMC 1531705. PMID 12082552.
Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (april 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106608 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049680 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: URG4 up-regulated gene 4".

[UniProt-6] "UniProt, Q8TCY9" (jezik: engleski). Pristupljeno 27. 9. 2021.

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