Protein 47 RNK-vezujućeg motiva jest protein koji je kod ljudi kodiran genom RBM47 sa hromosoma 4.[5]

RBM47
Dostupne strukture
PDBPretraga ortologa: PDBe RCSB
Spisak PDB ID kodova

2DIS

Identifikatori
AliasiRBM47
Vanjski ID-jeviMGI: 2384294 HomoloGene: 36932 GeneCards: RBM47
Lokacija gena (čovjek)
Hromosom 4 (čovjek)
Hrom.Hromosom 4 (čovjek)[1]
Hromosom 4 (čovjek)
Genomska lokacija za RBM47
Genomska lokacija za RBM47
Bend4p14Početak40,423,267 bp[1]
Kraj40,630,875 bp[1]
Lokacija gena (miš)
Hromosom 5 (miš)
Hrom.Hromosom 5 (miš)[2]
Hromosom 5 (miš)
Genomska lokacija za RBM47
Genomska lokacija za RBM47
Bend5|5 C3.1Početak66,173,892 bp[2]
Kraj66,330,461 bp[2]
Ontologija gena
Molekularna funkcija nucleic acid binding
vezivanje sa RNK
mRNA binding
Ćelijska komponenta jedro
Biološki proces hematopoietic progenitor cell differentiation
cytidine to uridine editing
Izvori:Amigo / QuickGO
Ortolozi
VrsteČovjekMiš
Entrez
Ensembl
UniProt
RefSeq (mRNK)

NM_001098634
NM_019027
NM_001371113
NM_001371114

NM_001127382
NM_001291226
NM_139065
NM_178446

RefSeq (bjelančevina)

NP_001092104
NP_061900
NP_001358042
NP_001358043

NP_001120854
NP_001278155
NP_620704
NP_848541

Lokacija (UCSC)Chr 4: 40.42 – 40.63 MbChr 5: 66.17 – 66.33 Mb
PubMed pretraga[3][4]
Wikipodaci
Pogledaj/uredi – čovjekPogledaj/uredi – miš

Aminokiselinska sekvenca

uredi

Dužina polipeptidnog lanca je 593 aminokiseline, а molekulska težina 64.099 Da.[6]

1020304050
MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQEN
GQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYEL
RLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDN
CRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVE
YESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYV
RNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNN
LNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCD
PYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGG
YSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIG
AQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAA
AAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATA
TIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY

Modelni organizmi

uredi

Za testiranje funkcije gena RBM47 proučvani su i modelni organizmi uvjetne linije nokaut-miševa Rbm47tm1a(EUCOMM)Wtsi za određivanje posljedica mogućih delecija. Generirani su u Institutu Wellcome Trust Sanger. Međutim, ni nakon duboke imunofenotipizacije nije nađena bilo kakva nenormalnost.[7][8][9][10][11]

Reference

uredi
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163694 - Ensembl, maj 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070780 - Ensembl, maj 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RNA binding motif protein 47". Pristupljeno 1. 6. 2013.
  6. ^ "UniProt, A0AV96" (jezik: engleski). Pristupljeno 30. 10. 2021.
  7. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  11. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.