Cycle on Wheels: Is APP Key to the AppBp1 Pathway? (Q94361807)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC4283775&resulttype=core&format=json

14 May 2020

title

Cycle on Wheels: Is APP Key to the AppBp1 Pathway? (English)

1 reference

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14 May 2020

5

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14 May 2020

author name string

Y Chen

1

1 reference

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14 May 2020

Rn Neve

2

1 reference

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14 May 2020

H Zheng

3

1 reference

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14 May 2020

Wts Griffin

4

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14 May 2020

Re Mrak

6

1 reference

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14 May 2020

publication date

1 January 2014

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14 May 2020

volume

1

1 reference

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14 May 2020

issue

2

1 reference

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

14 May 2020

cites work

1 reference

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G1/S cell cycle checkpoint defect in lymphocytes from patients with Alzheimer's disease

11 February 2021

1 reference

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The genetics of Alzheimer disease

11 February 2021

1 reference

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Cul4B regulates neural progenitor cell growth

11 February 2021

1 reference

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Neddylation dysfunction in Alzheimer's disease

11 February 2021

1 reference

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All in the Family: How the APPs Regulate Neurogenesis

11 February 2021

1 reference

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CRL Ubiquitin Ligases and DNA Damage Response

11 February 2021

1 reference

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Cell cycle activation and aneuploid neurons in Alzheimer's disease

11 February 2021

1 reference

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Functions of Aβ, sAPPα and sAPPβ : similarities and differences

11 February 2021

1 reference

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Twenty years of Alzheimer's disease-causing mutations

11 February 2021

1 reference

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The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy

11 February 2021

1 reference

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APP physiological and pathophysiological functions: insights from animal models.

11 February 2021

1 reference

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Biology and pathophysiology of the amyloid precursor protein

11 February 2021

1 reference

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Dynamic recruitment of licensing factor Cdt1 to sites of DNA damage

11 February 2021

1 reference

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Proliferating cell nuclear antigen-dependent rapid recruitment of Cdt1 and CRL4Cdt2 at DNA-damaged sites after UV irradiation in HeLa cells.

11 February 2021

1 reference

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Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

11 February 2021

1 reference

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Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

11 February 2021

1 reference

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

11 February 2021

1 reference

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Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

11 February 2021

1 reference

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A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

11 February 2021

1 reference

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Relationships between expression of apolipoprotein E and beta-amyloid precursor protein are altered in proximity to Alzheimer beta-amyloid plaques: potential explanations from cell culture studies

11 February 2021

1 reference

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease

11 February 2021

1 reference

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Abeta40 promotes neuronal cell fate in neural progenitor cells

11 February 2021

1 reference

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Cdc25A promotes G2/M transition in oocytes

11 February 2021

1 reference

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Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8.

11 February 2021

1 reference

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Amyloid precursor protein modulates beta-catenin degradation

11 February 2021

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Neuronal binucleation in Alzheimer disease hippocampus

11 February 2021

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11 February 2021

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Structural insights into early events in the conjugation of ubiquitin and ubiquitin-like proteins

11 February 2021

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Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease

11 February 2021

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DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase

11 February 2021

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APP locus duplication in a Finnish family with dementia and intracerebral haemorrhage

11 February 2021

1 reference

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Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression

11 February 2021

1 reference

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APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.

11 February 2021

1 reference

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SCF Fbx4/alphaB-crystallin cyclin D1 ubiquitin ligase: a license to destroy

11 February 2021

1 reference

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A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation

11 February 2021

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Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis

11 February 2021

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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases

11 February 2021

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

11 February 2021

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APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

11 February 2021

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A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis.

11 February 2021

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

11 February 2021

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Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53.

11 February 2021

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Mitotic entry: a matter of oscillating destruction

11 February 2021

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NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry

11 February 2021

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Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

11 February 2021

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Recruiting substrates to cullin 4-dependent ubiquitin ligases by DDB1

11 February 2021

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Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts.

11 February 2021

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Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein

11 February 2021

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Divide and die: cell cycle events as triggers of nerve cell death.

11 February 2021

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Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage

11 February 2021

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Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

11 February 2021

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p27Kip1 modulates cell migration through the regulation of RhoA activation.

11 February 2021

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The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1

11 February 2021

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Radiation-mediated proteolysis of CDT1 by CUL4–ROC1 and CSN complexes constitutes a new checkpoint

11 February 2021

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APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain

11 February 2021

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Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

11 February 2021

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DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3

11 February 2021

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Increased p27, an essential component of cell cycle control, in Alzheimer's disease

11 February 2021

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CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing

11 February 2021

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The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage

11 February 2021

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

11 February 2021

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Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease.

11 February 2021

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Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

11 February 2021

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

11 February 2021

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Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathway

11 February 2021

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Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex

11 February 2021

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The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

11 February 2021

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Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

11 February 2021

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Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

11 February 2021

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

11 February 2021

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Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch

11 February 2021

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DNA replication precedes neuronal cell death in Alzheimer's disease.

11 February 2021

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The F-box protein SKP2 binds to the phosphorylated threonine 380 in cyclin E and regulates ubiquitin-dependent degradation of cyclin E.

11 February 2021

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p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

11 February 2021

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Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases

11 February 2021

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Alzheimer's disease: a dysfunction of the amyloid precursor protein(1).

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The cell cycle Cdc25A tyrosine phosphatase is activated in degenerating postmitotic neurons in Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Purification and cloning of amyloid precursor protein beta-secretase from human brain

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Cullin 4A associates with the UV-damaged DNA-binding protein DDB

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Chromosome missegregation and trisomy 21 mosaicism in Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

CDK inhibitors: positive and negative regulators of G1-phase progression

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Life-long overexpression of S100beta in Down's syndrome: implications for Alzheimer pathogenesis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

A new NEDD8-ligating system for cullin-4A

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Cell cycle markers in the hippocampus in Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The SAR1 gene of Arabidopsis acts downstream of the AXR1 gene in auxin response.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Expression of cell division markers in the hippocampus in Alzheimer's disease and other neurodegenerative conditions

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Mechanisms of neuronal death in Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Decreases in protease nexins in Alzheimer's disease brain

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The effects of Alzheimer's disease, other dementias, and premortem course on beta-amyloid precursor protein messenger RNA in frontal cortex.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Ki-67 immunoreactivity in Alzheimer's disease and other neurodegenerative disorders

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

DNA damage and chronic neuronal degenerations

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Decreased DNA repair in familial Alzheimer's disease

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Cleavage of amyloid beta peptide during constitutive processing of its precursor

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Cell cycle dependence of laminar determination in developing neocortex

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Secretion of the beta/A4 amyloid precursor protein. Identification of a cleavage site in cultured mammalian cells

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

Multiple forms of ubiquitin-activating enzyme E1 from wheat. Identification of an essential cysteine by in vitro mutagenesis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

The ts41 mutation in Chinese hamster cells leads to successive S phases in the absence of intervening G2, M, and G1

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283775

11 February 2021

Identifiers

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC4283775&resulttype=core&format=json

14 May 2020

PubMed publication ID

25568892

1 reference