Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation (Q78836968)

From Wikidata

Jump to navigation Jump to search

scientific article published on 01 January 2003

Language	Label	Description	Also known as
English	Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation	scientific article published on 01 January 2003

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

1 reference

based on heuristic

inferred from title

apoptotic process

1 reference

based on heuristic

inferred from title

8

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

author name string

Marcello Arsura

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Ganesh R Panta

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Jennifer D Bilyeu

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Lakita G Cavin

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Mika A Sovak

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Aundrea A Oliver

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Valentina Factor

7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Frank Mercurio

9

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Snorri S Thorgeirsson

10

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Gail E Sonenshein

11

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

language of work or name

0 references

publication date

1 January 2003

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

22

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

412-425

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of the IkappaB kinase complex in oncogenic Ras- and Raf-mediated transformation of rat liver epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta1 inhibits NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells: a possible mechanism of growth suppression by TGF-beta1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

The NF-kappa B and I kappa B proteins: new discoveries and insights

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of apoptosis by Rel/NF-kappaB transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Constitutive phosphorylation of I kappa B alpha by casein kinase II

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Studying TGF-beta superfamily signaling by knockouts and knockins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Roles of Akt/PKB and IKK complex in constitutive induction of NF-kappaB in hepatocellular carcinomas of transforming growth factor alpha/c-myc transgenic mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

XIAP, the guardian angel

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

The MAPK kinase kinase TAK1 plays a central role in coupling the interleukin-1 receptor to both transcriptional and RNA-targeted mechanisms of gene regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

IKKalpha controls formation of the epidermis independently of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

The regulation of AP-1 activity by mitogen-activated protein kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Rel/NF-kappa B and I kappa B factors in oncogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TGFbeta signaling: receptors, transducers, and Mad proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Multiple signals converging on NF-kappaB.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of apoptosis in cultured hepatocytes and in the regressing liver by transforming growth factor-beta 1 occurs without activation of an endonuclease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad7 is induced by CD40 and protects WEHI 231 B-lymphocytes from transforming growth factor-beta -induced growth inhibition and apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Prevention of hepatic apoptosis and embryonic lethality in RelA/TNFR-1 double knockout mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Limb and skin abnormalities in mice lacking IKKalpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of JNK activation through NF-kappaB target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Critical role of Smads and AP-1 complex in transforming growth factor-beta -dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1206132

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.ONC.1206132

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Dimensions Publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12545162%20AND%20SRC:MED&resulttype=core&format=json

17 December 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q78836968&oldid=2222811827"