Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer (Q73816430)

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6 November 2019

title

Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer (English)

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6 November 2019

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Z Q Yuan

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6 November 2019

M Sun

2

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6 November 2019

R I Feldman

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6 November 2019

G Wang

4

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6 November 2019

X Ma

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6 November 2019

C Jiang

6

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6 November 2019

D Coppola

7

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6 November 2019

S V Nicosia

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6 November 2019

J Q Cheng

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6 November 2019

language of work or name

English

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publication date

1 May 2000

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6 November 2019

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6 November 2019

volume

19

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issue

19

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6 November 2019

page(s)

2324-2330

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Mechanism of activation and function of protein kinase B.

6 November 2019

cites work

1 reference

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7 January 2021

The inositol phosphatase SHIP inhibits Akt/PKB activation in B cells

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7 January 2021

Role of translocation in the activation and function of protein kinase B

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7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

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7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

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Oncogene amplification and prognosis in breast cancer: Relationship with systemic treatment

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7 January 2021

Gene amplification and tumor progression

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7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

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7 January 2021

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

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7 January 2021

Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis

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7 January 2021

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

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7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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7 January 2021

Somatic genetic changes in human breast cancer

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7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

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7 January 2021

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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7 January 2021

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

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7 January 2021

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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7 January 2021

Molecular cloning of a second form of rac protein kinase

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7 January 2021

A region of the 85-kilodalton (kDa) subunit of phosphatidylinositol 3-kinase binds the 110-kDa catalytic subunit in vivo

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7 January 2021

Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins

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7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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7 January 2021

Mitogenic activation, phosphorylation, and nuclear translocation of protein kinase Bbeta

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7 January 2021

Identification of a human Akt3 (protein kinase B gamma) which contains the regulatory serine phosphorylation site.

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7 January 2021

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7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

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7 January 2021

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

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7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

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7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

1 reference

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203598

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10822383%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 November 2019

1051386685

0 references

1 reference