Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis (Q73315751)

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3 November 2019

title

Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis (English)

1 reference

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amyotrophic lateral sclerosis

3 November 2019

main subject

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S Vukosavic

1

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3 November 2019

L Stefanis

2

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3 November 2019

V Jackson-Lewis

3

1 reference

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3 November 2019

C Guégan

4

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3 November 2019

N Romero

5

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3 November 2019

C Chen

6

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3 November 2019

M Dubois-Dauphin

7

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3 November 2019

S Przedborski

8

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3 November 2019

publication date

1 December 2000

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3 November 2019

published in

Journal of Neuroscience

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3 November 2019

volume

20

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3 November 2019

issue

24

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3 November 2019

page(s)

9119-9125

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Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

3 November 2019

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Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis

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Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase.

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12 December 2020

Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Cell death: the significance of apoptosis

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

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Staurosporine-induced apoptosis of cultured rat hippocampal neurons involves caspase-1-like proteases as upstream initiators and increased production of superoxide as a main downstream effector.

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Proteolytic activities that mediate apoptosis

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12 December 2020

"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders

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12 December 2020

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

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12 December 2020

Altered reactivity of superoxide dismutase in familial amyotrophic lateral sclerosis

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12 December 2020

Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis

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12 December 2020

Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation

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12 December 2020

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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12 December 2020

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis

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12 December 2020

Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).

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12 December 2020

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

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12 December 2020

Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells

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12 December 2020

A gain-of-function of an amyotrophic lateral sclerosis-associated Cu,Zn-superoxide dismutase mutant: An enhancement of free radical formation due to a decrease in Km for hydrogen peroxide

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12 December 2020

Superoxide dismutase in familial amyotrophic lateral sclerosis: models for gain of function

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12 December 2020

Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)

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12 December 2020

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease

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12 December 2020

Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia.

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12 December 2020

Differential requirement for caspase 9 in apoptotic pathways in vivo.

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12 December 2020

Activation of CPP-32 protease in hippocampal neurons following ischemia and epilepsy

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12 December 2020

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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12 December 2020

Fractin immunostaining for the detection of apoptotic cells and apoptotic bodies in formalin-fixed and paraffin-embedded tissue

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12 December 2020

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12 December 2020

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase

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12 December 2020

Effects of wild-type and mutated copper/zinc superoxide dismutase on neuronal survival and L-DOPA-induced toxicity in postnatal midbrain culture

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12 December 2020

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

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12 December 2020

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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12 December 2020

Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

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12 December 2020

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12 December 2020

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

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12 December 2020

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

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12 December 2020

Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis.

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12 December 2020

Apoptosis in substantia nigra following developmental striatal excitotoxic injury

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12 December 2020

Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

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12 December 2020

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

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12 December 2020

Caspases: enemies within

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12 December 2020

Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease

1 reference

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12 December 2020

Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury

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12 December 2020

Bcl-2 gene family in the nervous system

1 reference

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12 December 2020

Lack of apoptosis in mice with ALS

1 reference

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12 December 2020

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability

1 reference

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12 December 2020

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/11124989

12 December 2020

Developmental cell death in dopaminergic neurons of the substantia nigra of mice.

1 reference

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12 December 2020

10.1523/JNEUROSCI.20-24-09119.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11124989%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

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3 November 2019

PubMed publication ID

11124989

1 reference