Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS (Q73048419)

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scientific article published on 01 July 1999

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English	Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS	scientific article published on 01 July 1999

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scholarly article

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31 October 2019

Cyclin dependent kinase-5 (CDK-5) phosphorylates neurofilament heavy (NF-H) chain to generate epitopes for antibodies that label neurofilament accumulations in amyotrophic lateral sclerosis (ALS) and is present in affected motor neurones in ALS (English)

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31 October 2019

amyotrophic lateral sclerosis

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inferred from title

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P N Leigh

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31 October 2019

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N P Bajaj

1

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31 October 2019

S T al-Sarraj

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31 October 2019

V Anderson

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C C Miller

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31 October 2019

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1 July 1999

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31 October 2019

Progress in Neuro-Psychopharmacology & Biological Psychiatry

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5

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31 October 2019

833-850

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31 October 2019

Phosphorylation of neurofilament heavy-chain side-arm fragments by cyclin-dependent kinase-5 and glycogen synthase kinase-3alpha in transfected cells

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A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

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Identification of endogenously phosphorylated KSP sites in the high-molecular-weight rat neurofilament protein.

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Aberrant stress-induced phosphorylation of perikaryal neurofilaments

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Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death

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Cellular phosphorylation of neurofilament heavy-chain by cyclin-dependent kinase-5 masks the epitope for monoclonal antibody N52.

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Differential cellular phosphorylation of neurofilament heavy side-arms by glycogen synthase kinase-3 and cyclin-dependent kinase-5.

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Increased expression of cyclin-dependent kinase 5 in induced apoptotic neuron death in rat substantia nigra

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Cross-linker system between neurofilaments, microtubules, and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method

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Organization of mammalian neurofilament polypeptides within the neuronal cytoskeleton

1 reference

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Sequence and structure of the mouse gene coding for the largest neurofilament subunit

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Neuronal intermediate filaments

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Monoclonal antibodies distinguish several differentially phosphorylated states of the two largest rat neurofilament subunits (NF-H and NF-M) and demonstrate their existence in the normal nervous system of adult rats

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Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

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bcl-2 protein expression in aged brain and neurodegenerative diseases

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Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

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p35nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease

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Cyclin-dependent kinase 5 in Lewy body-like inclusions in anterior horn cells of a patient with sporadic amyotrophic lateral sclerosis

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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

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7 January 2021

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Phosphorylation of the high molecular weight neurofilament protein (NF-H) by Cdk5 and p35

1 reference

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Altered tau and neurofilament proteins in neuro-degenerative diseases: diagnostic implications for Alzheimer's disease and Lewy body dementias

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based on heuristic

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p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1 reference

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Mitogen-activated protein kinases (Erk1,2) phosphorylate Lys-Ser-Pro (KSP) repeats in neurofilament proteins NF-H and NF-M.

1 reference

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Cyclin-dependent kinase 5 is associated with apoptotic cell death during development and tissue remodeling

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Identifiers

10.1016/S0278-5846(99)00044-5

1 reference

Europe PubMed Central

PubMed publication ID

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31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10509378%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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