Delineating the role of cooperativity in the design of potent PROTACs for BTK. (Q64940546)

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12 April 2020

title

Delineating the role of cooperativity in the design of potent PROTACs for BTK (English)

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12 April 2020

8

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12 April 2020

Adelajda Zorba

1

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Veerabahu Shanmugasundaram

12 April 2020

30

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author name string

Chuong Nguyen

2

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Yingrong Xu

3

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Jeremy Starr

4

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Kris Borzilleri

5

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12 April 2020

James Smith

6

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Hongyao Zhu

7

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WeiDong Ding

9

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James Schiemer

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Xidong Feng

11

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Jeanne S Chang

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Daniel P Uccello

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Jennifer A Young

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Carmen N Garcia-Irrizary

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Lara Czabaniuk

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Brandon Schuff

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Robert Oliver

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Justin Montgomery

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Matthew M Hayward

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Jotham Coe

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Jinshan Chen

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Mark Niosi

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Jaymin C Shah

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Ayman El-Kattan

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Xiayang Qiu

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Graham M West

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Mark C Noe

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Adam M Gilbert

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Matthew F Brown

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publication date

16 July 2018

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Proceedings of the National Academy of Sciences of the United States of America

12 April 2020

published in

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volume

115

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issue

31

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12 April 2020

page(s)

E7285-E7292

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Identification of the von Hippel-Lindau disease tumor suppressor gene

12 April 2020

cites work

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12 December 2020

BTK, the tyrosine kinase affected in X-linked agammaglobulinemia.

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12 December 2020

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

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12 December 2020

Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

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12 December 2020

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice

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12 December 2020

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

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12 December 2020

A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation

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12 December 2020

Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

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12 December 2020

Genome-wide and functional annotation of human E3 ubiquitin ligases identifies MULAN, a mitochondrial E3 that regulates the organelle's dynamics and signaling

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12 December 2020

Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

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12 December 2020

Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

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12 December 2020

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain

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12 December 2020

Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.

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12 December 2020

Structural assembly of cullin-RING ubiquitin ligase complexes

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12 December 2020

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein.

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12 December 2020

Development of target protein-selective degradation inducer for protein knockdown.

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12 December 2020

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.

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12 December 2020

The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation

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12 December 2020

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

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12 December 2020

Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide

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12 December 2020

X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7

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12 December 2020

Structure-based prediction of protein–protein interactions on a genome-wide scale

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12 December 2020

Inhibitor of apoptosis (IAP) proteins-modulators of cell death and inflammation

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12 December 2020

A comprehensive mathematical model for three-body binding equilibria

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12 December 2020

Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans

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12 December 2020

Targeting BTK with ibrutinib in relapsed or refractory mantle-cell lymphoma

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12 December 2020

Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia

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12 December 2020

Selective inhibition of BTK prevents murine lupus and antibody-mediated glomerulonephritis.

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12 December 2020

Building and remodelling Cullin-RING E3 ubiquitin ligases

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12 December 2020

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

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12 December 2020

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

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12 December 2020

Bruton's tyrosine kinase (BTK) inhibitors in clinical trials

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12 December 2020

Ibrutinib in B-cell Lymphomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Oncogenic protein interfaces: small molecules, big challenges.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.

1 reference

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12 December 2020

DRUG DEVELOPMENT. Phthalimide conjugation as a strategy for in vivo target protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

1 reference

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12 December 2020

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4.

1 reference

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12 December 2020

Catalytic in vivo protein knockdown by small-molecule PROTACs.

1 reference

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12 December 2020

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL.

1 reference

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12 December 2020

Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Induced protein degradation: an emerging drug discovery paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Transcriptional Addiction in Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Structural basis of PROTAC cooperative recognition for selective protein degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

BTKC481S-Mediated Resistance to Ibrutinib in Chronic Lymphocytic Leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30012605

12 December 2020

Identifiers

DOI

10.1073/PNAS.1803662115

1 reference

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12 April 2020

0 references

1 reference

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12 April 2020

PubMed publication ID

30012605

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