Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases (Q60917514)

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15 April 2020

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Cytokine Networks Dysregulation during HTLV-1 Infection and Associated Diseases (English)

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adult T-cell leukemia/lymphoma

15 April 2020

main subject

infectious disease

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Retroviridae infectious disease

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19 October 2019

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RNA virus infectious disease

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Human T-lymphotropic virus 1 infectious disease

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Human T-lymphotropic virus 1

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15 April 2020

Renaud Mahieux

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15 April 2020

Jorge Casseb

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15 April 2020

Helene Dutartre

5

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author name string

Nicolas Futsch

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publication date

5 December 2018

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Cytokine induction in HTLV-I associated myelopathy and adult T-cell leukemia: Alternate molecular mechanisms underlying retroviral pathogenesis

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The human interferon-gamma gene contains an inducible promoter that can be transactivated by tax I and II.

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Mononuclear cells from peripheral blood of adult donors and from cord blood are equally protected by alpha- and beta-interferons against infection with HTLV-I.

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The efficacy of interferon-alpha treatment in human T-lymphotropic virus type-I-associated myelopathy.

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Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia

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Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy

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Nationwide survey of HTLV-I-associated myelopathy in Japan: association with blood transfusion

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Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis

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12 December 2020

HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor.

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12 December 2020

Dissociation of interleukin-2-mediated cell proliferation and interleukin-2 receptor upregulation in adult T-cell leukemia cells

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Expression of TGF-beta gene in adult T cell leukemia

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Spontaneous proliferation of peripheral blood lymphocytes increased in patients with HTLV-I-associated myelopathy.

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12 December 2020

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells

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12 December 2020

Leukemic cells from some adult T-cell leukemia patients proliferate in response to interleukin-4

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12 December 2020

T-Cell Growth Factor Gene: Lack of Expression in Human T-Cell Leukemia-Lymphoma Virus-Infected Cells

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12 December 2020

Anti-viral and immunomodulatory effects of interferon-alpha on cultured lymphocytes from patients with human T lymphotropic virus type I-associated myelopathy (HAM/TSP).

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12 December 2020

Constitutively Activated Jak-STAT Pathway in T Cells Transformed with HTLV-I

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12 December 2020

Detection of human T-lymphotropic virus type I (HTLV-I) tax RNA in the central nervous system of HTLV-I-associated myelopathy/tropical spastic paraparesis patients by in situ hybridization

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12 December 2020

Human T cell lymphotropic virus type I-induced T cell activation. Resistance to TGF-beta 1-induced suppression.

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12 December 2020

Immunocytochemical analysis of the cellular infiltrate in the spinal cord lesions in HTLV-I-associated myelopathy

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12 December 2020

Interleukin-4 induces proliferation of adult T-cell leukemia cells

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12 December 2020

Diversity of immunobiological functions of T-cell lines established from patients with adult T-cell leukaemia

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12 December 2020

Characterization and regulation of interleukin-4 receptor in adult T-cell leukemia cells.

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12 December 2020

Interleukin-10 gene expression in adult T-cell leukemia.

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12 December 2020

Long-term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: a combined clinical, virological and immunological study

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12 December 2020

Human T cell leukemia virus type I (HTLV-I) and human diseases

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12 December 2020

Features of the cytokines secreted by adult T cell leukemia (ATL) cells

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12 December 2020

Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8+ HTLV-1-specific cytotoxic T cells

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12 December 2020

Proliferation of adult T cell leukemia/lymphoma cells is associated with the constitutive activation of JAK/STAT proteins

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12 December 2020

Circulating interleukin-6 levels are elevated in adult T-cell leukaemia/lymphoma patients and correlate with adverse clinical features and survival

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https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor alpha on ATL cells

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12 December 2020

Differences in phosphorylation of the IL-2R associated JAK/STAT proteins between HTLV-I(+), IL-2-independent and IL-2-dependent cell lines and uncultured leukemic cells from patients with adult T-cell lymphoma/leukemia

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12 December 2020

HTLV-I-infected T cells evade the antiproliferative action of IFN-beta

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12 December 2020

Relationship between the clinical efficacy of pentoxifylline treatment and elevation of serum T helper type 2 cytokine levels in patients with human T-lymphotropic virus type I-associated myelopathy.

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12 December 2020

Proliferation response to interleukin-2 and Jak/Stat activation of T cells immortalized by human T-cell lymphotropic virus type 1 is independent of open reading frame I expression

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12 December 2020

Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4

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12 December 2020

Long-term effects of HTLV-1 on brain astrocytes: sustained expression of Tax-1 associated with synthesis of inflammatory mediators.

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12 December 2020

Human T-cell leukemia virus type I oncoprotein Tax represses Smad-dependent transforming growth factor beta signaling through interaction with CREB-binding protein/p300.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Localization of retrovirus in the central nervous system of a patient co-infected with HTLV-1 and HIV with HAM/TSP and HIV-associated dementia

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12 December 2020

Increased HTLV-I proviral load and preferential expansion of HTLV-I Tax-specific CD8+ T cells in cerebrospinal fluid from patients with HAM/TSP.

1 reference

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12 December 2020

Selected cytotoxic T lymphocytes with high specificity for HTLV-I in cerebrospinal fluid from a HAM/TSP patient

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell lymphotropic virus type 1 tax inhibits transforming growth factor-beta signaling by blocking the association of Smad proteins with Smad-binding element

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Different cytokine production in tax-expressing cells between patients with human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis and asymptomatic HTLV-I carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Majority of interferon-gamma-producing CD4+ cells in patients infected with human T cell lymphotrophic virus do not express tax protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Activation of interleukin-13 expression in T cells from HTLV-1-infected individuals and in chronically infected cell lines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL-6 trans-signaling: the heat is on.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Depletion and impaired interferon-alpha-producing capacity of blood plasmacytoid dendritic cells in human T-cell leukaemia virus type I-infected individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Interleukin-13 overexpression by tax transactivation: a potential autocrine stimulus in human T-cell leukemia virus-infected lymphocytes

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https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Enhanced tumorigenesis in HTLV-1 tax-transgenic mice deficient in interferon-gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL-2- and STAT5-regulated cytokine gene expression in cells expressing the Tax protein of HTLV-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Tumor immunity against adult T-cell leukemia

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https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

TGF-beta control of cell proliferation

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https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The interferon response circuit: induction and suppression by pathogenic viruses

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12 December 2020

Clinical significance of serum Th1-, Th2- and regulatory T cells-associated cytokines in adult T-cell leukemia/lymphoma: high interleukin-5 and -10 levels are significant unfavorable prognostic factors

1 reference

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12 December 2020

Human T-cell leukemia virus type-I Tax induces expression of interleukin-6 receptor (IL-6R): Shedding of soluble IL-6R and activation of STAT3 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The HTLV-I p30 interferes with TLR4 signaling and modulates the release of pro- and anti-inflammatory cytokines from human macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Reduced frequency, diversity, and function of human T cell leukemia virus type 1-specific CD8+ T cell in adult T cell leukemia patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Proinflammatory cytokine gene induction by human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 Tax in primary human glial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IRF-4 and c-Rel expression in antiviral-resistant adult T-cell leukemia/lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL-10 produced by CD4+ and CD8+ T cells emerge as a putative immunoregulatory mechanism to counterbalance the monocyte-derived TNF-alpha and guarantee asymptomatic clinical status during chronic HTLV-I infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL-10, T cell exhaustion and viral persistence

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

High production of RANTES and MIP-1alpha in the tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Augmented expression of programmed death-1 in both neoplastic and non-neoplastic CD4+ T-cells in adult T-cell leukemia/lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell leukemia virus type 1 blunts signaling by interferon alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Dysregulation of TGF-beta signaling and regulatory and effector T-cell function in virus-induced neuroinflammatory disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell leukemia virus type 1 Tax modulates interferon-alpha signal transduction through competitive usage of the coactivator CBP/p300.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

PD-1/PD-L1 expression in human T-cell leukemia virus type 1 carriers and adult T-cell leukemia/lymphoma patients.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-kappaB and NFAT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Alteration of blood-brain barrier integrity by retroviral infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1-associated adult T-cell leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T cell lymphotropic virus 1 manipulates interferon regulatory signals by controlling the TAK1-IRF3 and IRF4 pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-lymphotropic virus type 1-induced CC chemokine ligand 22 maintains a high frequency of functional FoxP3+ regulatory T cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Autocrine/paracrine cytokine stimulation of leukemic cell proliferation in smoldering and chronic adult T-cell leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 evades type I interferon antiviral signaling by inducing the suppressor of cytokine signaling 1 (SOCS1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Biology of interleukin-10.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Double control systems for human T-cell leukemia virus type 1 by innate and acquired immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Constitutive expression of immunosuppression-associated cytokine genes in a panel of human T-leukemia-cell lines - high-incidence of transforming growth-factor-Beta gene-expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T cell leukemia virus type 1 Tax inhibits innate antiviral signaling via NF-kappaB-dependent induction of SOCS1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 bZIP factor enhances TGF-β signaling through p300 coactivator

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 and innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Systems biology approaches reveal a specific interferon-inducible signature in HTLV-1 associated myelopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+ T cells in virus-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The impact of interferon-alpha treatment on clinical and immunovirological aspects of HTLV-1-associated myelopathy in northeast of Iran

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Pre-morbid human T-lymphotropic virus type I proviral load, rather than percentage of abnormal lymphocytes, is associated with an increased risk of aggressive adult T-cell leukemia/lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Epidemiological Aspects and World Distribution of HTLV-1 Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Clinical Trials and Treatment of ATL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudine induces p53 signaling and apoptosis in HTLV-1-infected cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Alpha interferon restricts human T-lymphotropic virus type 1 and 2 de novo infection through PKR activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 clonality in adult T-cell leukaemia and non-malignant HTLV-1 infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Regulation of type I interferon responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 Tax protein recruitment into IKKε and TBK1 kinase complexes enhances IFN-I expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Innate immune pattern recognition: a cell biological perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Type I interferons in infectious disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Oncogenic human T-cell lymphotropic virus type 1 tax suppression of primary innate immune signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

High IFN-γ/IL-10 expression ratio and increased frequency of persistent human T-cell lymphotropic virus type 1-infected clones are associated with human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis development.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The evolution of IL-4 and IL-13 and their receptor subunits

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Viral Source-Independent High Susceptibility of Dendritic Cells to Human T-Cell Leukemia Virus Type 1 Infection Compared to That of T Lymphocytes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Integrated molecular analysis of adult T cell leukemia/lymphoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Immunological signature of the different clinical stages of the HTLV-1 infection: establishing serum biomarkers for HTLV-1-associated disease morbidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Interleukin-2: Biology, Design and Application

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT).

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Plasmatic proinflammatory chemokines levels are tricky markers to monitoring HTLV-1 carriers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1-associated myelopathy/tropical spastic paraparesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

The effect of HTLV-1 virulence factors (HBZ, Tax, proviral load), HLA class I and plasma neopterin on manifestation of HTLV-1 associated myelopathy tropical spastic paraparesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Early Onset of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) and Adult T-cell Leukemia/Lymphoma (ATL): Systematic Search and Review

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Mediators Go Together: High Production of CXCL9, CXCL10, IFN-γ, and TNF-α in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IFN-γ promotes transendothelial migration of CD4+ T cells across the blood-brain barrier

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Positive and negative regulation of type I Interferons by the human T cell leukemia virus antisense protein HBZ.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IL10 Release upon PD-1 Blockade Sustains Immunosuppression in Ovarian Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Switching and loss of cellular cytokine producing capacity characterize in vivo viral infection and malignant transformation in human T- lymphotropic virus type 1 infection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Role of Wild-type and Recombinant Human T-cell Leukemia Viruses in Lymphoproliferative Disease in Humanized NSG Mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

An activating mutation of interferon regulatory factor 4 (IRF4) in adult T cell leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

IFI16 regulates HTLV-1 replication through promoting HTLV-1 RTI-induced innate immune responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1) Tax-specific T-cell exhaustion in HTLV-1-infected individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/30563084

12 December 2020

Identifiers

DOI

10.3390/V10120691

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30563084%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30563084%20AND%20SRC:MED&resulttype=core&format=json

15 April 2020

PubMed publication ID

30563084

1 reference