Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology (Q58761831)

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English	Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology	article

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scholarly article

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Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aβ plaque pathology (English)

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author name string

Sarah M Rothman

1

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Keith Q Tanis

2

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Pallavi Gandhi

3

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Vladislav Malkov

4

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Jacob Marcus

5

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Michelle Pearson

6

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Richard Stevens

7

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Jason Gilliland

8

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Christopher Ware

9

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Veeravan Mahadomrongkul

10

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Elaine O'Loughlin

11

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Gonzalo Zeballos

12

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Roger Smith

13

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Bonnie J Howell

14

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Joel Klappenbach

15

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Matthew Kennedy

16

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Christian Mirescu

17

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language of work or name

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publication date

6 September 2018

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Journal of Neuroinflammation

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15

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1

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256

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copyright license

Creative Commons Attribution 4.0 International

6 September 2018

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April 2022 Public Data File from Crossref

copyright status

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APP mouse models for Alzheimer's disease preclinical studies

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

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30 November 2018

Evaluation of a Genetic Risk Score to Improve Risk Prediction for Alzheimer's Disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Altered motility of plaque-associated microglia in a model of Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Innate Immunity Fights Alzheimer's Disease

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30 November 2018

Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease.

1 reference

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30 November 2018

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2).

1 reference

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30 November 2018

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

TREM2 in CNS homeostasis and neurodegenerative disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Neuroinflammation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

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30 November 2018

Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

1 reference

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30 November 2018

Targeting the β secretase BACE1 for Alzheimer's disease therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Diverse macrophage populations mediate acute lung inflammation and resolution

1 reference

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30 November 2018

Identification of a unique TGF-β-dependent molecular and functional signature in microglia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

The microglial sensome revealed by direct RNA sequencing

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Integrated systems approach identifies genetic nodes and networks in late-onset Alzheimer's disease

1 reference

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30 November 2018

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Genetic insights in Alzheimer's disease

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30 November 2018

TREM2 Variants in Alzheimer's Disease

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30 November 2018

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

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30 November 2018

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging

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30 November 2018

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Unravelling mononuclear phagocyte heterogeneity

1 reference

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30 November 2018

Genome-wide analysis of genetic loci associated with Alzheimer disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Microglial C5aR (CD88) expression correlates with amyloid-beta deposition in murine models of Alzheimer's disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

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30 November 2018

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

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30 November 2018

A randomized controlled study on effects of ibuprofen on cognitive progression of Alzheimer's disease.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Classification and basic pathology of Alzheimer disease

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Mutations in TREM2 lead to pure early-onset dementia without bone cysts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Neuropsychological tests and functional nuclear neuroimaging provide evidence of subclinical impairment in Nasu-Hakola disease heterozygotes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy--PLOSL): a dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Specific Compositions of Amyloid-β Peptides as the Determinant of Toxic β-Aggregation

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30 November 2018

Randomized pilot study of nimesulide treatment in Alzheimer's disease

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30 November 2018

Microglia, amyloid and dementia in alzheimer disease. A correlative study.

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30 November 2018

Association of microglia with amyloid plaques in brains of APP23 transgenic mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6127905

30 November 2018

Microglial response to amyloid plaques in APPsw transgenic mice.

1 reference

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30 November 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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30 November 2018

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

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30 November 2018

Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease.

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30 November 2018

Morphologic association between microglia and senile plaque amyloid in Alzheimer's disease

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30 November 2018

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid

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30 November 2018

Transgenic mouse models of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/30189875

12 December 2020

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10.1186/S12974-018-1265-7

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12974-018-1265-7

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