Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease? (Q53232752)

12 May 2018

http://europepmc.org/abstract/MED/10652477

title

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease? (English)

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

author

Richard Killick

3

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

author name string

Anderton BH

1

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

Dayanandan R

2

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

Lovestone S

4

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

publication date

1 February 2000

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

published in

Trends in Molecular Medicine

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

volume

6

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

issue

2

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

page(s)

54-59

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

cites work

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Tau in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Signal transduction by the Wnt family of ligands

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Protein kinase Czeta is a negative regulator of protein kinase B activity

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Interaction of axin and Dvl-2 proteins regulates Dvl-2-stimulated TCF-dependent transcription.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Interaction between Wingless and Notch signaling pathways mediated by dishevelled.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Direct interaction of Alzheimer's disease-related presenilin 1 with armadillo protein p0071

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Isolation of human delta-catenin and its binding specificity with presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Direct association of presenilin-1 with beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Tau phosphorylation in cells transfected with wild-type or an Alzheimer's disease mutant Presenilin 1

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

1 reference

https://api.crossref.org/works/10.1016%2FS1357-4310%2899%2901640-8

7 January 2021

10.1016/S1357-4310(99)01640-8

Identifiers

DOI

1 reference

12 May 2018

http://europepmc.org/abstract/MED/10652477

1 reference

12 May 2018