Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. (Q52200995)

26 April 2018

http://europepmc.org/abstract/MED/8673924

title

Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. (English)

1 reference

26 April 2018

http://europepmc.org/abstract/MED/8673924

1 reference

Alonso AC

1

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26 April 2018

http://europepmc.org/abstract/MED/8673924

Grundke-Iqbal I

series ordinal

2

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26 April 2018

http://europepmc.org/abstract/MED/8673924

Iqbal K

series ordinal

3

1 reference

26 April 2018

http://europepmc.org/abstract/MED/8673924

language of work or name

English

0 references

publication date

1 July 1996

1 reference

26 April 2018

http://europepmc.org/abstract/MED/8673924

published in

Nature Medicine

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26 April 2018

http://europepmc.org/abstract/MED/8673924

volume

2

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26 April 2018

http://europepmc.org/abstract/MED/8673924

issue

7

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26 April 2018

http://europepmc.org/abstract/MED/8673924

page(s)

783-787

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26 April 2018

http://europepmc.org/abstract/MED/8673924

cites work

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7 January 2021

Histopathological criteria for progressive dementia disorders: clinical-pathological correlation and classification by multivariate data analysis

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7 January 2021

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

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7 January 2021

Brain levels of microtubule-associated protein tau are elevated in Alzheimer's disease: a radioimmuno-slot-blot assay for nanograms of the protein

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7 January 2021

Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

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https://api.crossref.org/works/10.1038%2FNM0796-783

7 January 2021

Alzheimer paired helical filaments. Restoration of the biological activity by dephosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FNM0796-783

7 January 2021

Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B.

1 reference

https://api.crossref.org/works/10.1038%2FNM0796-783

7 January 2021

Defective brain microtubule assembly in Alzheimer's disease

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7 January 2021

Alzheimer neurofibrillary tangles contain 2.1 nm filaments structurally identical to the microtubule-associated protein τ: a high-resolution transmission electron microscope study of tangles and senile plaque core amyloid

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7 January 2021

Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro

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7 January 2021

The microtubule binding repeats of tau protein assemble into filaments like those found in Alzheimer's disease

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7 January 2021

Assembly of Alzheimer-like filaments from full-length tau protein

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7 January 2021

Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments

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7 January 2021

Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer's disease

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7 January 2021

Phosphoprotein phosphatase activities in Alzheimer disease brain

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7 January 2021

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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7 January 2021

Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filaments

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7 January 2021

Assay of proteins in the presence of interfering materials

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7 January 2021

Microtubule Assembly in the Absence of Added Nucleotides

1 reference

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7 January 2021

Decoration and stabilization of intact, smooth-walled microtubules with microtubule-associated proteins

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7 January 2021

Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.

1 reference

https://api.crossref.org/works/10.1038%2FNM0796-783

7 January 2021

Identifiers

DOI

10.1038/NM0796-783

1 reference

26 April 2018

http://europepmc.org/abstract/MED/8673924

1 reference

26 April 2018