Modulating hedgehog signaling can attenuate the severity of osteoarthritis. (Q51922455)

17 April 2018

http://europepmc.org/abstract/MED/19915594

title

Modulating hedgehog signaling can attenuate the severity of osteoarthritis. (English)

1 reference

17 April 2018

http://europepmc.org/abstract/MED/19915594

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Alvin C Lin

1

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Brian L Seeto

2

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Justyna M Bartoszko

3

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Michael A Khoury

4

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http://europepmc.org/abstract/MED/19915594

Heather Whetstone

5

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Louisa Ho

6

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Claire Hsu

7

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17 April 2018

http://europepmc.org/abstract/MED/19915594

S Amanda Ali

8

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17 April 2018

http://europepmc.org/abstract/MED/19915594

Benjamin A Alman

9

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17 April 2018

http://europepmc.org/abstract/MED/19915594

language of work or name

English

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publication date

15 November 2009

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17 April 2018

http://europepmc.org/abstract/MED/19915594

published in

Nature Medicine

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17 April 2018

http://europepmc.org/abstract/MED/19915594

volume

15

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17 April 2018

http://europepmc.org/abstract/MED/19915594

issue

12

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17 April 2018

http://europepmc.org/abstract/MED/19915594

page(s)

1421-1425

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17 April 2018

http://europepmc.org/abstract/MED/19915594

cites work

Altered neural cell fates and medulloblastoma in mouse patched mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Expression of proteoglycans and collagen in the hypertrophic phase of experimental osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Increased type II collagen degradation and very early focal cartilage degeneration is associated with upregulation of chondrocyte differentiation related genes in early human articular cartilage lesions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Smoothened mutants reveal redundant roles for Shh and Ihh signaling including regulation of L/R symmetry by the mouse node

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Opportunities for improving the therapeutic ratio for patients with sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

A mutant PTH/PTHrP type I receptor in enchondromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Repeated mechanical loading enhances the expression of Indian hedgehog in condylar cartilage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Generation of a transgenic mouse in which Cre recombinase is expressed under control of the type II collagen promoter and doxycycline administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Synovitis score: discrimination between chronic low-grade and high-grade synovitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Dysregulation of hedgehog signalling predisposes to synovial chondromatosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Histological assessment of cartilage repair: a report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Methods in studying ECM degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Genetics of osteoarthritis: early developmental clues to an old disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Ihh/Gli2 signaling promotes osteoblast differentiation by regulating Runx2 expression and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Hedgehog signaling in mature osteoblasts regulates bone formation and resorption by controlling PTHrP and RANKL expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Characterization of the human ADAMTS-5 (aggrecanase-2) gene promoter

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Major biological obstacles for persistent cell-based regeneration of articular cartilage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Transduction of passaged human articular chondrocytes with adenoviral, retroviral, and lentiviral vectors and the effects of enhanced expression of SOX9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Effect of adenovirus-mediated overexpression of bovine ADAMTS-4 and human ADAMTS-5 in primary bovine articular chondrocyte pellet culture system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Integration of signaling pathways regulating chondrocyte differentiation during endochondral bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19915594

12 December 2020

Factors regulating condylar cartilage growth under repeated load application

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNM.2055

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NM.2055

1 reference

17 April 2018

http://europepmc.org/abstract/MED/19915594

1 reference

17 April 2018