Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. (Q51239957)

1 April 2018

http://europepmc.org/abstract/MED/16567806

title

Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. (English)

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1 April 2018

http://europepmc.org/abstract/MED/16567806

main subject

transmembrane protein

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Birgitte Holst

5

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Thue W Schwartz

object named as

Thue W Schwartz

6

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Thomas M Frimurer

2

object named as

Thomas M Frimurer

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1 April 2018

http://europepmc.org/abstract/MED/16567806

author name string

Christian E Elling

1

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1 April 2018

http://europepmc.org/abstract/MED/16567806

Lars-Ole Gerlach

3

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http://europepmc.org/abstract/MED/16567806

Rasmus Jorgensen

4

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1 April 2018

http://europepmc.org/abstract/MED/16567806

language of work or name

English

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publication date

27 March 2006

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1 April 2018

http://europepmc.org/abstract/MED/16567806

published in

Journal of Biological Chemistry

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1 April 2018

http://europepmc.org/abstract/MED/16567806

volume

281

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http://europepmc.org/abstract/MED/16567806

issue

25

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http://europepmc.org/abstract/MED/16567806

page(s)

17337-17346

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1 April 2018

http://europepmc.org/abstract/MED/16567806

cites work

Molecular tinkering of G protein-coupled receptors: an evolutionary success

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Historical review: a brief history and personal retrospective of seven-transmembrane receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

The druggable genome: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Drug design strategies for targeting G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Is there a 'lock' for all agonist 'keys' in 7TM receptors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Differential transcriptional activation in vitro by NF-kappa B/Rel proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Structural features and light-dependent changes in the cytoplasmic interhelical E-F loop region of rhodopsin: a site-directed spin-labeling study

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Rhodopsin structure, dynamics, and activation: a perspective from crystallography, site-directed spin labeling, sulfhydryl reactivity, and disulfide cross-linking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Role of the conserved NPxxY(x)5,6F motif in the rhodopsin ground state and during activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Evidence that helix 8 of rhodopsin acts as a membrane-dependent conformational switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Crystal structure of rhodopsin: A G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Structure of bovine rhodopsin in a trigonal crystal form.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Electron crystallography reveals the structure of metarhodopsin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

The Protein Data Bank: a computer-based archival file for macromolecular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Locating ligand-binding sites in 7TM receptors by protein engineering.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Comparative protein structure modeling of genes and genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Comparative protein modelling by satisfaction of spatial restraints

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Modeling of loops in protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Relibase: design and development of a database for comprehensive analysis of protein-ligand interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Monte Carlo-minimization approach to the multiple-minima problem in protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Use of a quantitative structure-property relationship to design larger model proteins that fold rapidly.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Conversion of antagonist-binding site to metal-ion site in the tachykinin NK-1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Construction of a high affinity zinc switch in the kappa-opioid receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Refinement of a homology model of the mu-opioid receptor using distance constraints from intrinsic and engineered zinc-binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Changes in interhelical hydrogen bonding upon rhodopsin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

"Induced-fit" mechanism for catecholamine binding to the beta2-adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Agonist binding: a multistep process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Tethering: fragment-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

Common structural basis for constitutive activity of the ghrelin receptor family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M512510200

21 January 2018

Identifiers

DOI

10.1074/JBC.M512510200

1 reference

1 April 2018

http://europepmc.org/abstract/MED/16567806

1 reference

1 April 2018